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MegaALS SIGNED

Unravelling the Interplay between Metabolism, Gut Microbiome and Adaptive Immunity in Amyotrophic Lateral Sclerosis

Total Cost €

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EC-Contrib. €

0

Partnership

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 MegaALS project word cloud

Explore the words cloud of the MegaALS project. It provides you a very rough idea of what is the project "MegaALS" about.

prevention    lifestyle    profiling    lack    epidemiological    interactions    controls    individuals    translate    devastating    substantially    microbiota    usefulness    donors    hypothesize    healthy    disease    immunity    combining    caloric    leads    immune    diagnosis    offers    first    quality    observational    systemic    therapeutic    stockholm    tested    compare    sclerosis    gut    specificity    multiple    experimental    molecular    als    metagenomic    underlying    physiology    combines    diet    strategy    treatments    death    intervention    contrast    understand    sod1g93a    preventive    interplay    nervous    ultimate    overarching    proteomic    warranted    central    spouses    metabolism    environmental    possibility    regimen    rare    lateral    adaptive    platforms    innovative    uses    human    population    microbiome    transplant    fecal    profiles    model    effectiveness    siblings    risk    etiopathogenesis    contributes    disorder    unrelated    mouse    mechanisms    few    amyotrophic    significantly    explore    treatment    physiological    neurodegenerative    animal   

Project "MegaALS" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙499˙196 €
 EC max contribution 1˙499˙196 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙499˙196.00

Map

 Project objective

Amyotrophic lateral sclerosis (ALS) is a rare but devastating neurodegenerative disorder that in lack of effective treatments leads to death within a few years of diagnosis. ALS is increasingly being recognized as a systemic disease affecting not only the central nervous system but also other physiological aspects. We hypothesize that there is a disease-specific interplay between metabolism, gut microbiome and adaptive immunity, which substantially contributes to the etiopathogenesis of ALS. The overarching aim of this project is therefore to explore such interplay, and to assess the effectiveness of a treatment regimen that specifically targets it. Using a population-based case-control study of ALS in Stockholm, I will first characterize the complex interactions between metabolism, microbiome, and immunity in ALS, through comprehensive proteomic, metagenomic and immune-response profiling. The specificity of these interactions will be tested in contrast to healthy individuals at high risk for ALS (siblings), individuals with similar environmental and lifestyle factors (spouses), and unrelated population-controls. I will then use an established ALS mouse model (SOD1G93A) to understand the usefulness of combining a high-caloric diet with a fecal microbiota transplant from healthy human donors in disease prevention and treatment. To better understand the underlying mechanisms, I will compare microbiome and immune-response profiles before and after the intervention. The proposed research is unique as it 1) combines innovative molecular platforms with a high-quality epidemiological study design, 2) uses a novel strategy of investigating multiple aspects of human physiology, and 3) offers a possibility to directly translate findings between human observational and animal experimental studies. The ultimate goal is to significantly advance our knowledge about ALS as a disease, and more importantly to identify novel and highly warranted preventive and therapeutic targets.

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The information about "MEGAALS" are provided by the European Opendata Portal: CORDIS opendata.

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