Opendata, web and dolomites

EPICROP SIGNED

Dissecting epistasis for enhanced crop productivity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EPICROP project word cloud

Explore the words cloud of the EPICROP project. It provides you a very rough idea of what is the project "EPICROP" about.

improvements    epistatic    series    exhaustive    agriculture    traits    molecular    predictably    economically    screen    uncover    naturally    untapped    additive    cell    box    transcript    signatures    epistasis    understand    mads    panel    editing    regulate    clear    networks    linear    acting    weak    navigate    preliminary    sensitizing    resource    crops    cryptic    loci    gene    differences    cas9    architecture    biology    genotype    diversity    meet    outcomes    tomato    suggests    fruit    functional    area    flower    plant    genome    quantitative    reveal    occurring    crispr    profiling    unknown    genes    crop    phenotype    experimental    differentiation    allelic    principles    interactions    natural    model    first    leads    utilize    mainly    mutagenesis    breeding    plants    improvement    trait    productivity    perturbations    predictable    fundamental    modifier    guide    data    efforts    regulatory    cassettes    dissect    trans    genetic    stem    map    variation    quantitatively   

Project "EPICROP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙903 €
 EC max contribution 1˙499˙903 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙903.00

Map

 Project objective

A major goal in plant biology is to understand how naturally occurring genetic variation leads to quantitative differences in economically important traits. Efforts to navigate the genotype-to-phenotype map are often focused on linear genetic interactions. As a result, crop breeding is mainly driven by loci with predictable additive effects. However, it has become clear that quantitative trait variation often results from perturbations of complex genetic networks. Thus, understanding epistasis, or interactions between genes, is key for our ability to predictably improve crops. To meet this challenge, this project will reveal and dissect epistatic interactions in gene regulatory networks that guide stem cell differentiation in the model crop tomato. In the first aim, I will utilize exhaustive allelic series for epistatic MADS-box genes that quantitatively regulate flower and fruit production as an experimental model system to study fundamental principles of epistasis that can be applied to other genetic networks. Genome-wide transcript profiling will be used to reveal molecular signatures of epistasis and potential targets for predictable crop improvement by advanced CRISPR/Cas9 gene editing technology. Further, my preliminary data suggests that epistasis is widespread and important across major productivity traits in tomato. Thus, in a second aim, I will access this untapped resource of cryptic genetic variation by sensitizing a tomato diversity panel for weak epistatic effects from unknown natural modifier loci of stem cell differentiation using trans-acting CRISPR/Cas9 editing cassettes. This screen represents a new approach to mutagenesis in plants with potential to reveal cryptic variation in other system. The outcomes of this project will advance our knowledge in a fundamental area of plant genome biology, help uncover and understand the functional architecture of epistasis, and have potential to bring significant improvements to agriculture.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPICROP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EPICROP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

TRUST (2018)

Truth and Semantics

Read More  

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More