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EPICROP SIGNED

Dissecting epistasis for enhanced crop productivity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EPICROP project word cloud

Explore the words cloud of the EPICROP project. It provides you a very rough idea of what is the project "EPICROP" about.

understand    improvements    navigate    unknown    first    differentiation    breeding    natural    perturbations    variation    trait    box    stem    leads    functional    regulatory    quantitative    improvement    reveal    predictable    principles    traits    occurring    biology    loci    fundamental    cassettes    additive    dissect    epistatic    genome    efforts    molecular    flower    allelic    area    cas9    sensitizing    genetic    weak    linear    plants    experimental    mads    editing    naturally    trans    regulate    genes    signatures    guide    suggests    clear    screen    preliminary    plant    outcomes    interactions    networks    meet    resource    mainly    crop    economically    differences    acting    productivity    cryptic    predictably    panel    data    gene    untapped    map    tomato    diversity    uncover    exhaustive    genotype    cell    fruit    crispr    quantitatively    utilize    crops    modifier    transcript    mutagenesis    epistasis    agriculture    phenotype    series    model    profiling    architecture   

Project "EPICROP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙903 €
 EC max contribution 1˙499˙903 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙903.00

Map

 Project objective

A major goal in plant biology is to understand how naturally occurring genetic variation leads to quantitative differences in economically important traits. Efforts to navigate the genotype-to-phenotype map are often focused on linear genetic interactions. As a result, crop breeding is mainly driven by loci with predictable additive effects. However, it has become clear that quantitative trait variation often results from perturbations of complex genetic networks. Thus, understanding epistasis, or interactions between genes, is key for our ability to predictably improve crops. To meet this challenge, this project will reveal and dissect epistatic interactions in gene regulatory networks that guide stem cell differentiation in the model crop tomato. In the first aim, I will utilize exhaustive allelic series for epistatic MADS-box genes that quantitatively regulate flower and fruit production as an experimental model system to study fundamental principles of epistasis that can be applied to other genetic networks. Genome-wide transcript profiling will be used to reveal molecular signatures of epistasis and potential targets for predictable crop improvement by advanced CRISPR/Cas9 gene editing technology. Further, my preliminary data suggests that epistasis is widespread and important across major productivity traits in tomato. Thus, in a second aim, I will access this untapped resource of cryptic genetic variation by sensitizing a tomato diversity panel for weak epistatic effects from unknown natural modifier loci of stem cell differentiation using trans-acting CRISPR/Cas9 editing cassettes. This screen represents a new approach to mutagenesis in plants with potential to reveal cryptic variation in other system. The outcomes of this project will advance our knowledge in a fundamental area of plant genome biology, help uncover and understand the functional architecture of epistasis, and have potential to bring significant improvements to agriculture.

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The information about "EPICROP" are provided by the European Opendata Portal: CORDIS opendata.

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