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Dissecting epistasis for enhanced crop productivity

Total Cost €


EC-Contrib. €






 EPICROP project word cloud

Explore the words cloud of the EPICROP project. It provides you a very rough idea of what is the project "EPICROP" about.

fruit    trans    untapped    unknown    genome    dissect    regulate    improvement    acting    outcomes    allelic    functional    genotype    model    epistasis    naturally    trait    variation    experimental    breeding    additive    phenotype    first    predictably    principles    fundamental    cassettes    preliminary    clear    signatures    interactions    occurring    map    box    profiling    transcript    suggests    quantitatively    mads    sensitizing    linear    diversity    improvements    exhaustive    mainly    traits    leads    utilize    data    plant    differences    agriculture    natural    crop    epistatic    understand    guide    genetic    productivity    area    editing    biology    regulatory    modifier    series    meet    perturbations    reveal    navigate    predictable    architecture    plants    resource    uncover    economically    cell    efforts    tomato    genes    crispr    screen    quantitative    mutagenesis    crops    flower    gene    weak    stem    panel    networks    differentiation    cas9    cryptic    loci    molecular   

Project "EPICROP" data sheet

The following table provides information about the project.


Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙903 €
 EC max contribution 1˙499˙903 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙903.00


 Project objective

A major goal in plant biology is to understand how naturally occurring genetic variation leads to quantitative differences in economically important traits. Efforts to navigate the genotype-to-phenotype map are often focused on linear genetic interactions. As a result, crop breeding is mainly driven by loci with predictable additive effects. However, it has become clear that quantitative trait variation often results from perturbations of complex genetic networks. Thus, understanding epistasis, or interactions between genes, is key for our ability to predictably improve crops. To meet this challenge, this project will reveal and dissect epistatic interactions in gene regulatory networks that guide stem cell differentiation in the model crop tomato. In the first aim, I will utilize exhaustive allelic series for epistatic MADS-box genes that quantitatively regulate flower and fruit production as an experimental model system to study fundamental principles of epistasis that can be applied to other genetic networks. Genome-wide transcript profiling will be used to reveal molecular signatures of epistasis and potential targets for predictable crop improvement by advanced CRISPR/Cas9 gene editing technology. Further, my preliminary data suggests that epistasis is widespread and important across major productivity traits in tomato. Thus, in a second aim, I will access this untapped resource of cryptic genetic variation by sensitizing a tomato diversity panel for weak epistatic effects from unknown natural modifier loci of stem cell differentiation using trans-acting CRISPR/Cas9 editing cassettes. This screen represents a new approach to mutagenesis in plants with potential to reveal cryptic variation in other system. The outcomes of this project will advance our knowledge in a fundamental area of plant genome biology, help uncover and understand the functional architecture of epistasis, and have potential to bring significant improvements to agriculture.

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The information about "EPICROP" are provided by the European Opendata Portal: CORDIS opendata.

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