Opendata, web and dolomites

EPICROP SIGNED

Dissecting epistasis for enhanced crop productivity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EPICROP project word cloud

Explore the words cloud of the EPICROP project. It provides you a very rough idea of what is the project "EPICROP" about.

phenotype    area    diversity    screen    quantitative    genetic    economically    plants    trait    networks    gene    genes    sensitizing    allelic    leads    breeding    fruit    acting    genotype    modifier    guide    dissect    occurring    meet    untapped    map    cell    plant    mutagenesis    differences    panel    box    cas9    model    naturally    exhaustive    reveal    crops    fundamental    improvements    utilize    predictably    flower    resource    additive    molecular    functional    loci    suggests    uncover    genome    perturbations    efforts    mads    signatures    profiling    preliminary    quantitatively    cassettes    traits    biology    regulatory    architecture    agriculture    cryptic    natural    stem    navigate    transcript    predictable    linear    unknown    productivity    epistasis    series    data    trans    weak    mainly    clear    understand    crispr    editing    epistatic    first    principles    improvement    outcomes    crop    interactions    regulate    tomato    differentiation    experimental    variation   

Project "EPICROP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙903 €
 EC max contribution 1˙499˙903 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙903.00

Map

 Project objective

A major goal in plant biology is to understand how naturally occurring genetic variation leads to quantitative differences in economically important traits. Efforts to navigate the genotype-to-phenotype map are often focused on linear genetic interactions. As a result, crop breeding is mainly driven by loci with predictable additive effects. However, it has become clear that quantitative trait variation often results from perturbations of complex genetic networks. Thus, understanding epistasis, or interactions between genes, is key for our ability to predictably improve crops. To meet this challenge, this project will reveal and dissect epistatic interactions in gene regulatory networks that guide stem cell differentiation in the model crop tomato. In the first aim, I will utilize exhaustive allelic series for epistatic MADS-box genes that quantitatively regulate flower and fruit production as an experimental model system to study fundamental principles of epistasis that can be applied to other genetic networks. Genome-wide transcript profiling will be used to reveal molecular signatures of epistasis and potential targets for predictable crop improvement by advanced CRISPR/Cas9 gene editing technology. Further, my preliminary data suggests that epistasis is widespread and important across major productivity traits in tomato. Thus, in a second aim, I will access this untapped resource of cryptic genetic variation by sensitizing a tomato diversity panel for weak epistatic effects from unknown natural modifier loci of stem cell differentiation using trans-acting CRISPR/Cas9 editing cassettes. This screen represents a new approach to mutagenesis in plants with potential to reveal cryptic variation in other system. The outcomes of this project will advance our knowledge in a fundamental area of plant genome biology, help uncover and understand the functional architecture of epistasis, and have potential to bring significant improvements to agriculture.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPICROP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EPICROP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

UrbTerr (2019)

Urban Terrorism in Europe (2004-2019): Remembering, Imagining, and Anticipating Violence

Read More  

CARBOFLOW (2020)

Streamlined carbon dioxide conversion in ionic liquids – a platform strategy for modern carbonylation chemistry

Read More  

FLATBANDS (2020)

Exploring strong correlations in flat bands

Read More