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RodBot

Automated Microhandling System for X-ray Crystallography

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RodBot project word cloud

Explore the words cloud of the RodBot project. It provides you a very rough idea of what is the project "RodBot" about.

millimeter    precisely    loop    front    noncontact    living    material    form    environment    manipulating    therapeutic    transported    delivering    delicate    grant    intensity    harmless    bottleneck    fluidic    trapped    fragile    throughput    micromanipulation    action    catalysis    reynolds    scientists    sizes    objects    macromolecules    botmed    generates    core    proteins    surface    external    3d    erc    extraction    rising    generally    enzymes    ray    individual    rodbot    magnetic    supporting    crystallized    manually    influence    penetrate    utilized    experts    object    entities    separating    harvesting    lift    rolls    bimolecular    size    environments    drug    device    named    few    substrate    protein    micro    auspices    interactions    flows    biological    suspended    varying    magnetically    microrobot    understand    crystallography    fragility    crystals    beam    liquid    manipulation    chromatin    manipulate    powered    group    location    mechanism    readily    organisms    molecules    exposure    vortex    trained    microns    off    enzymatic    wireless    structure   

Project "RodBot" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 148˙885 €
 EC max contribution 148˙885 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 148˙885.00

Map

 Project objective

Crystallography is one of the most important methods for studying the 3D structure of complex biological macromolecules. The knowledge of the detailed structure of proteins, enzymes and chromatin allows scientists to understand concepts such as bimolecular interactions, mechanism of enzymatic catalysis and the therapeutic action of drug molecules. A major bottleneck of high-throughput crystallography is harvesting the crystallized form of these molecules from their liquid environments and manipulating them to a location that enables exposure to the X-ray beam. Due of the fragility and large size range of crystals this step has so far been done manually by trained experts.

The proposed research will advance the concept of using a wireless, magnetically driven microrobot, named the RodBot, for micromanipulation of delicate biological entities. The RodBot rolls on a supporting surface in a low Reynolds number fluidic environment and generates rising flows in front of it, and a vortex above it. The flows are utilized for noncontact micromanipulation of fragile objects such as protein crystals. As the RodBot approaches a micro-object, the object comes under the influence of the rising flows which lift it off the substrate. The suspended object is then trapped in the vortex and can be transported to a pre-defined location. The RodBot is powered and controlled by external, low intensity magnetic fields which are generally harmless to living organisms and can readily penetrate most biological material. The flows generated by the RodBot can precisely manipulate crystals of sizes varying from a few microns up to one millimeter. It is capable of separating individual crystals from a group and delivering it to an extraction device called the loop.

The core magnetic manipulation technology for the wireless control of the RodBot has been developed under the auspices of the ERC Advanced grant project BOTMED.

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The information about "RODBOT" are provided by the European Opendata Portal: CORDIS opendata.

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