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RodBot

Automated Microhandling System for X-ray Crystallography

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 RodBot project word cloud

Explore the words cloud of the RodBot project. It provides you a very rough idea of what is the project "RodBot" about.

named    environment    delicate    enzymatic    scientists    bimolecular    generally    rising    loop    trained    enzymes    magnetic    therapeutic    vortex    ray    microns    flows    noncontact    device    size    organisms    mechanism    manipulating    fragile    entities    action    molecules    manipulation    microrobot    manipulate    millimeter    core    extraction    individual    chromatin    interactions    bottleneck    front    proteins    readily    material    reynolds    location    understand    botmed    experts    surface    structure    crystallized    rolls    generates    trapped    magnetically    objects    beam    auspices    crystallography    suspended    powered    micromanipulation    wireless    substrate    environments    liquid    precisely    supporting    object    fluidic    off    intensity    penetrate    form    delivering    lift    sizes    few    varying    micro    erc    biological    protein    external    harvesting    manually    catalysis    drug    macromolecules    influence    transported    rodbot    throughput    living    crystals    group    separating    3d    utilized    harmless    exposure    fragility    grant   

Project "RodBot" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 148˙885 €
 EC max contribution 148˙885 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 148˙885.00

Map

 Project objective

Crystallography is one of the most important methods for studying the 3D structure of complex biological macromolecules. The knowledge of the detailed structure of proteins, enzymes and chromatin allows scientists to understand concepts such as bimolecular interactions, mechanism of enzymatic catalysis and the therapeutic action of drug molecules. A major bottleneck of high-throughput crystallography is harvesting the crystallized form of these molecules from their liquid environments and manipulating them to a location that enables exposure to the X-ray beam. Due of the fragility and large size range of crystals this step has so far been done manually by trained experts.

The proposed research will advance the concept of using a wireless, magnetically driven microrobot, named the RodBot, for micromanipulation of delicate biological entities. The RodBot rolls on a supporting surface in a low Reynolds number fluidic environment and generates rising flows in front of it, and a vortex above it. The flows are utilized for noncontact micromanipulation of fragile objects such as protein crystals. As the RodBot approaches a micro-object, the object comes under the influence of the rising flows which lift it off the substrate. The suspended object is then trapped in the vortex and can be transported to a pre-defined location. The RodBot is powered and controlled by external, low intensity magnetic fields which are generally harmless to living organisms and can readily penetrate most biological material. The flows generated by the RodBot can precisely manipulate crystals of sizes varying from a few microns up to one millimeter. It is capable of separating individual crystals from a group and delivering it to an extraction device called the loop.

The core magnetic manipulation technology for the wireless control of the RodBot has been developed under the auspices of the ERC Advanced grant project BOTMED.

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The information about "RODBOT" are provided by the European Opendata Portal: CORDIS opendata.

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