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BRIGHTER SIGNED

BIOPRINTING BY LIGHT-SHEET LITHOGRAPHY: ENGINEERING COMPLEX TISSUES WITH HIGH RESOLUTION AT HIGH SPEED

Total Cost €

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EC-Contrib. €

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Partnership

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 BRIGHTER project word cloud

Explore the words cloud of the BRIGHTER project. It provides you a very rough idea of what is the project "BRIGHTER" about.

limited    original    maintaining    incorporate    layer    decrease    pharma    photomasks    niches    appendix    stem    follicles    laden    recreate    insufficient    hydrogels    scientific    bioprinting    fails    material    device    confined    alternative    business    voxels    severely    cell    microfeatures    lithography    hair    printing    selectively    sectors    density    stiffness    resolution    fabrication    integrity    native    digital    geometries    dimensional    glands    matrix    morphologies    nature    proof    vivo    remarkable    surrogates    heterogeneous    fine    superior    anatomical    network    speed    additional    crosslinking    brighter    clinical    ultimate    create    requiring    engineered    tuned    tissues    disruptive    structures    compartments    3d    vascular    spatial    sheet    invaginations    cellular    academy    tissue    times    illumination    mechanical    sacrificial    combine    poor    wavy    impacting    viability    light    hollow    skin    evaginations    contrast    sweat    vitro    photocrosslink   

Project "BRIGHTER" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 3˙520˙720 €
 EC max contribution 3˙459˙052 € (98%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 750˙106.00
2    MYCRONIC AB SE (TABY) participant 945˙960.00
3    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 704˙346.00
4    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) participant 588˙015.00
5    CELLENDES GMBH DE (REUTLINGEN) participant 470˙625.00

Map

 Project objective

Engineered tissues are key elements in both in vitro and in vivo applications, strongly impacting the academy, pharma and clinical sectors. Bioprinting is considered the most promising method to produce such engineered tissues. However, current bioprinting methods are severely limited by both insufficient speed and spatial resolution. Long printing times decrease cell viability, while poor spatial resolution fails to recreate the heterogeneous nature of native tissues. BRIGHTER will develop a new bioprinting technology able to produce tissue surrogates with high spatial resolution at high printing speed using an original top-down lithography approach, in contrast with current bottom-up, layer-by-layer bioprinting methods. BRIGHTER will combine high-speed light-sheet illumination and high-resolution digital photomasks to selectively photocrosslink cell-laden hydrogels in confined voxels and produce three-dimensional complex geometries. This process will enable the bioprinting of key anatomical microfeatures of tissue such as invaginations, evaginations or wavy morphologies. It will also incorporate hollow vascular structures while maintaining tissue mechanical integrity without the need of additional sacrificial material. As a remarkable feature, matrix crosslinking density can be fine-tuned using BRIGHTER’s approach, allowing the fabrication of cellular compartments requiring specific matrix stiffness such as stem cell niches. The proof-of-concept application will be bioprinting viable engineered skin tissues exploiting the key features of the BRIGHTER device: skin appendix (hair follicles, sweat glands), stem cell niches and a vascular network. The ultimate goal is to provide a superior alternative to state-or-the art 3D bioprinting with a disruptive bioprinting technology that would create new scientific and business opportunities.

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The information about "BRIGHTER" are provided by the European Opendata Portal: CORDIS opendata.

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