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BRIGHTER SIGNED

BIOPRINTING BY LIGHT-SHEET LITHOGRAPHY: ENGINEERING COMPLEX TISSUES WITH HIGH RESOLUTION AT HIGH SPEED

Total Cost €

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EC-Contrib. €

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Partnership

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 BRIGHTER project word cloud

Explore the words cloud of the BRIGHTER project. It provides you a very rough idea of what is the project "BRIGHTER" about.

academy    niches    decrease    disruptive    structures    light    additional    alternative    compartments    remarkable    microfeatures    follicles    glands    skin    engineered    limited    viability    crosslinking    sacrificial    digital    poor    material    anatomical    combine    recreate    requiring    vivo    incorporate    clinical    fails    superior    vitro    brighter    stem    pharma    selectively    scientific    tissue    resolution    geometries    speed    photomasks    3d    wavy    sweat    laden    hydrogels    fabrication    proof    hollow    nature    sheet    density    matrix    business    times    printing    cell    layer    invaginations    dimensional    insufficient    native    integrity    illumination    photocrosslink    confined    maintaining    vascular    cellular    mechanical    fine    evaginations    tuned    device    sectors    spatial    stiffness    voxels    heterogeneous    tissues    severely    appendix    lithography    impacting    network    bioprinting    ultimate    hair    original    contrast    morphologies    create    surrogates   

Project "BRIGHTER" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 3˙520˙720 €
 EC max contribution 3˙459˙052 € (98%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 750˙106.00
2    MYCRONIC AB SE (TABY) participant 945˙960.00
3    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 704˙346.00
4    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) participant 588˙015.00
5    CELLENDES GMBH DE (REUTLINGEN) participant 470˙625.00

Map

 Project objective

Engineered tissues are key elements in both in vitro and in vivo applications, strongly impacting the academy, pharma and clinical sectors. Bioprinting is considered the most promising method to produce such engineered tissues. However, current bioprinting methods are severely limited by both insufficient speed and spatial resolution. Long printing times decrease cell viability, while poor spatial resolution fails to recreate the heterogeneous nature of native tissues. BRIGHTER will develop a new bioprinting technology able to produce tissue surrogates with high spatial resolution at high printing speed using an original top-down lithography approach, in contrast with current bottom-up, layer-by-layer bioprinting methods. BRIGHTER will combine high-speed light-sheet illumination and high-resolution digital photomasks to selectively photocrosslink cell-laden hydrogels in confined voxels and produce three-dimensional complex geometries. This process will enable the bioprinting of key anatomical microfeatures of tissue such as invaginations, evaginations or wavy morphologies. It will also incorporate hollow vascular structures while maintaining tissue mechanical integrity without the need of additional sacrificial material. As a remarkable feature, matrix crosslinking density can be fine-tuned using BRIGHTER’s approach, allowing the fabrication of cellular compartments requiring specific matrix stiffness such as stem cell niches. The proof-of-concept application will be bioprinting viable engineered skin tissues exploiting the key features of the BRIGHTER device: skin appendix (hair follicles, sweat glands), stem cell niches and a vascular network. The ultimate goal is to provide a superior alternative to state-or-the art 3D bioprinting with a disruptive bioprinting technology that would create new scientific and business opportunities.

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The information about "BRIGHTER" are provided by the European Opendata Portal: CORDIS opendata.

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