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AGE-MEMORY SIGNED

Identification of insulin signalling factors that delay age-related memory impairment

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

AGE-MEMORY project word cloud

Explore the words cloud of the AGE-MEMORY project. It provides you a very rough idea of what is the project "AGE-MEMORY" about.

neuronal underlay will physiological experimental imaging flies evolutionarily experiments elegans drosophila first iis techniques conserved regulators platforms manipulation relative denominate worms shown nervous depending discovery memory expand combined cognitive conservation govern signalling insulin ages humans putative transcription biological function profiling impairment mediators pharmacological universal dissect mechanisms differentially morphological genes deterioration longevity ami organisms delay ageing effect age decline mutants elucidation

Project "AGE-MEMORY" data sheet

The following table provides information about the project.

Coordinator	IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	http://www.tavernarakislab.gr/index-en.html
Total cost	164˙653 €
EC max contribution	164˙653 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-06-01 to 2018-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	coordinator	164˙653.00

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Project objective

Elucidation of the biological mechanisms that govern ageing can facilitate the discovery of evolutionarily conserved factors, which denominate physiological deterioration in humans. Here we will study the effect of insulin/insulin like growth factor signalling (IIS), shown to delay ageing in several organisms, on age-related memory impairment (AMI). We will use both C. elegans and Drosophila as experimental platforms, to test evolutionarily conservation of findings. Longevity combined with memory experiments will be applied in several IIS mutants. We will dissect IIS to find putative mediators of IIS effects on cognitive function. To identify relative mechanisms we will measure activity of known AMI regulators in IIS mutants. Depending on our results, our study will expand on transcription profiling worms and flies IIS mutants of different ages. Neuronal genes differentially affected by IIS will be further studied. We will use novel imaging techniques to characterize morphological changes that occur through ageing in the nervous system. This study is a first step to identify universal mechanisms that underlay cognitive function decline. Pharmacological manipulation of such mechanisms could delay AMI in humans.

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The information about "AGE-MEMORY" are provided by the European Opendata Portal: CORDIS opendata.