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EngineeringBAP SIGNED

Engineering brain activity patterns for therapeutics of neuropsychiatric and neurological disorders

Total Cost €

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EC-Contrib. €

0

Partnership

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 EngineeringBAP project word cloud

Explore the words cloud of the EngineeringBAP project. It provides you a very rough idea of what is the project "EngineeringBAP" about.

power    blood    lack    sub    drug    limited    connectivity    reading    mutant    dysfunctions    symptoms    cocktails    correct    microparticles    primates    neuron    noninvasively    zebrafish    phenotypes    technologies    mouse    constitutes    neurological    neuromodulator    barrier    anxiety    employ    first    scalability    functional    minimally    brain    battery    cortical    pathological    multiple    ecog    behavioural    direct    circuit    vivo    minimallyinvasive    detect    underlying    proof    plan    obsessive    flexible    designed    data    achievable    abnormal    reverse    damaging    neuromodulators    treatment    localized    precise    receptive    human    intractable    behaviours    superficial    layers    measuring    manipulating    humans    patterns    mu    neuromorphic    pulses    resolution    circuits    modulating    single    ultrasound    compulsivity    signals    rodents    networks    neuropsychiatric    opening    modifications    simultaneously    invasive    engineered    disorders    preliminary    neuronal    precision    comprehensively    model   

Project "EngineeringBAP" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙998˙984 €
 EC max contribution 1˙998˙984 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 1˙998˙984.00

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 Project objective

Neuropsychiatric and neurological disorders are complex dysfunctions of neuronal circuits. Their treatment has been limited by the lack of non-invasive methods for measuring the underlying circuit dysfunctions, and for direct and localized modifications of these circuits. We propose minimally invasive technologies for measuring brain activity and functional connectivity patterns, and for manipulating them directly in vivo to correct the abnormal behavioural phenotypes (in rodents with potential scalability to non-human primates and humans). First, we present a proof-of-principle study on mutant zebrafish, in which we correct whole-brain level abnormal activity patterns and behaviours by using large-scale single-neuron resolution measurements, and by simultaneously modulating multiple sub-networks via neuromodulator cocktails. Next, we present strong preliminary data in rodents and our plan: (1) For manipulating brain circuits in rodents/primates noninvasively, we will develop technologies that can deliver receptive-specific neuromodulators to spatially precise brain targets without opening/damaging the blood brain barrier. These methods will employ engineered ultrasound pulses and drug carrying microparticles we designed. (2) For reading out the brain circuits in rodents/primates, we will develop flexible low-power neuromorphic μECoG circuits that can detect single neuron signals from superficial cortical layers of many cortical areas simultaneously. (3) Finally, these novel technologies will be comprehensively evaluated on a mouse model of obsessive compulsivity and anxiety using a battery of behavioural tasks to reverse the pathological symptoms (beyond what is achievable by existing approaches). This project constitutes a major step towards the development and testing of minimallyinvasive and high-precision technologies for manipulating brain activity patterns, which can impact both our understanding of the brain and treatment of intractable brain disorders.

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