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EngineeringBAP SIGNED

Engineering brain activity patterns for therapeutics of neuropsychiatric and neurological disorders

Total Cost €

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EC-Contrib. €

0

Partnership

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 EngineeringBAP project word cloud

Explore the words cloud of the EngineeringBAP project. It provides you a very rough idea of what is the project "EngineeringBAP" about.

mu    battery    detect    minimallyinvasive    blood    neuromodulator    opening    minimally    modifications    brain    receptive    direct    human    vivo    invasive    functional    signals    networks    disorders    engineered    model    plan    noninvasively    neuromodulators    pulses    humans    localized    first    circuits    neuronal    reverse    resolution    neuromorphic    zebrafish    abnormal    modulating    limited    obsessive    technologies    pathological    single    achievable    layers    correct    scalability    rodents    flexible    mutant    intractable    drug    lack    manipulating    simultaneously    dysfunctions    behaviours    symptoms    power    data    neurological    underlying    ecog    circuit    neuropsychiatric    connectivity    cortical    ultrasound    cocktails    compulsivity    mouse    treatment    precise    anxiety    microparticles    multiple    superficial    neuron    barrier    proof    behavioural    sub    preliminary    precision    constitutes    employ    patterns    comprehensively    primates    damaging    phenotypes    measuring    reading    designed   

Project "EngineeringBAP" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙998˙984 €
 EC max contribution 1˙998˙984 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 1˙998˙984.00

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 Project objective

Neuropsychiatric and neurological disorders are complex dysfunctions of neuronal circuits. Their treatment has been limited by the lack of non-invasive methods for measuring the underlying circuit dysfunctions, and for direct and localized modifications of these circuits. We propose minimally invasive technologies for measuring brain activity and functional connectivity patterns, and for manipulating them directly in vivo to correct the abnormal behavioural phenotypes (in rodents with potential scalability to non-human primates and humans). First, we present a proof-of-principle study on mutant zebrafish, in which we correct whole-brain level abnormal activity patterns and behaviours by using large-scale single-neuron resolution measurements, and by simultaneously modulating multiple sub-networks via neuromodulator cocktails. Next, we present strong preliminary data in rodents and our plan: (1) For manipulating brain circuits in rodents/primates noninvasively, we will develop technologies that can deliver receptive-specific neuromodulators to spatially precise brain targets without opening/damaging the blood brain barrier. These methods will employ engineered ultrasound pulses and drug carrying microparticles we designed. (2) For reading out the brain circuits in rodents/primates, we will develop flexible low-power neuromorphic μECoG circuits that can detect single neuron signals from superficial cortical layers of many cortical areas simultaneously. (3) Finally, these novel technologies will be comprehensively evaluated on a mouse model of obsessive compulsivity and anxiety using a battery of behavioural tasks to reverse the pathological symptoms (beyond what is achievable by existing approaches). This project constitutes a major step towards the development and testing of minimallyinvasive and high-precision technologies for manipulating brain activity patterns, which can impact both our understanding of the brain and treatment of intractable brain disorders.

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