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EngineeringBAP SIGNED

Engineering brain activity patterns for therapeutics of neuropsychiatric and neurological disorders

Total Cost €

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EC-Contrib. €

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Partnership

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 EngineeringBAP project word cloud

Explore the words cloud of the EngineeringBAP project. It provides you a very rough idea of what is the project "EngineeringBAP" about.

neurological    human    primates    brain    multiple    behaviours    microparticles    measuring    resolution    sub    vivo    functional    flexible    achievable    manipulating    precise    intractable    mouse    detect    humans    technologies    abnormal    proof    networks    neuron    circuits    cocktails    modulating    superficial    compulsivity    battery    minimallyinvasive    dysfunctions    localized    zebrafish    reverse    comprehensively    direct    data    single    barrier    invasive    model    designed    neuromodulator    disorders    noninvasively    damaging    phenotypes    correct    reading    mu    limited    obsessive    cortical    neuropsychiatric    employ    constitutes    rodents    blood    pulses    mutant    behavioural    neuromodulators    precision    modifications    lack    connectivity    signals    simultaneously    engineered    first    ultrasound    preliminary    anxiety    symptoms    pathological    drug    layers    opening    neuronal    scalability    receptive    plan    underlying    ecog    circuit    patterns    neuromorphic    treatment    power    minimally   

Project "EngineeringBAP" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙998˙984 €
 EC max contribution 1˙998˙984 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 1˙998˙984.00

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 Project objective

Neuropsychiatric and neurological disorders are complex dysfunctions of neuronal circuits. Their treatment has been limited by the lack of non-invasive methods for measuring the underlying circuit dysfunctions, and for direct and localized modifications of these circuits. We propose minimally invasive technologies for measuring brain activity and functional connectivity patterns, and for manipulating them directly in vivo to correct the abnormal behavioural phenotypes (in rodents with potential scalability to non-human primates and humans). First, we present a proof-of-principle study on mutant zebrafish, in which we correct whole-brain level abnormal activity patterns and behaviours by using large-scale single-neuron resolution measurements, and by simultaneously modulating multiple sub-networks via neuromodulator cocktails. Next, we present strong preliminary data in rodents and our plan: (1) For manipulating brain circuits in rodents/primates noninvasively, we will develop technologies that can deliver receptive-specific neuromodulators to spatially precise brain targets without opening/damaging the blood brain barrier. These methods will employ engineered ultrasound pulses and drug carrying microparticles we designed. (2) For reading out the brain circuits in rodents/primates, we will develop flexible low-power neuromorphic μECoG circuits that can detect single neuron signals from superficial cortical layers of many cortical areas simultaneously. (3) Finally, these novel technologies will be comprehensively evaluated on a mouse model of obsessive compulsivity and anxiety using a battery of behavioural tasks to reverse the pathological symptoms (beyond what is achievable by existing approaches). This project constitutes a major step towards the development and testing of minimallyinvasive and high-precision technologies for manipulating brain activity patterns, which can impact both our understanding of the brain and treatment of intractable brain disorders.

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