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CellularLogistics SIGNED

Cellular Logistics: Form, Formation and Function of the Neuronal Microtubule Cytoskeleton

Total Cost €

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EC-Contrib. €

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Partnership

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 CellularLogistics project word cloud

Explore the words cloud of the CellularLogistics project. It provides you a very rough idea of what is the project "CellularLogistics" about.

cells    plus    organization    technique    polarization    underlies    biology    cellular    organelles    cytoskeleton    combine    proteins    either    lab    function    networks    mts    architectural    dynamics    form    minus    remained    techniques    preferred    revealed    molecular    microscopy    mitotic    arrays    revealing    division    destinations    create    ways    guides    positioning    map    intracellular    central    utilized    cytoskeletal    directed    determines    nevertheless    neurons    neuronal    aid    paint    unknown    configurations    morphology    kinesins    functioning    logistics    network    directionality    transport    mathematical    dendritic    uncover    anticipated    previously    opposite    mechanisms    mixed    resolve    dendrites    orientations    mt    modifications    3d    dynein    modulates    motors    complete    modulate    explore    polarity    stability    motor    ordered    selectively    specialized    proper    move    cell    relation    structural    unravel    spindle   

Project "CellularLogistics" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 2˙000˙000.00

Map

 Project objective

The organization and dynamics of the MT (MT) cytoskeleton underlies the morphology, polarization and division of most cells. The structural polarity of MT determines the directionality of motor proteins, which move selectively towards either the MT plus (most kinesins) or minus end (dynein) to control the transport and positioning of proteins and organelles. Understanding how different cellular MT arrays, such as the mitotic spindle or neuronal MT networks, are built and utilized to ensure proper cellular logistics is a central challenge in cell biology. Recently, our lab has introduced a new technique, motor-PAINT, to directly resolve MT polarity and the relation between MT orientations, stability and modifications. This revealed that in neurons, the mixed polarity MT network in the dendrites is much more ordered than previously anticipated. MTs with opposite orientations have different properties and are preferred by distinct kinesins, revealing an architectural principle that could explain why different plus-end directed motors move towards distinct destinations. Nevertheless, the mechanisms by which this specialized organization is established and the different ways in which it modulates intracellular transport have remained unknown. To resolve how cytoskeletal organization guides transport, I propose to explore the form, formation and functioning of the neuronal MT cytoskeleton. We will combine advanced microscopy, molecular biology, and mathematical modelling to: 1) Create a complete 3D map of the dendritic MT cytoskeleton – form. 2) Unravel the mechanisms that establish MT organization in dendrites – formation. 3) Explore how specific MT configurations modulate intracellular transport – function. This research will uncover key mechanisms of cytoskeletal organization and transport in neurons. In addition, our techniques and concepts will aid understanding intracellular transport in other cellular systems.

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The information about "CELLULARLOGISTICS" are provided by the European Opendata Portal: CORDIS opendata.

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