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CellularLogistics SIGNED

Cellular Logistics: Form, Formation and Function of the Neuronal Microtubule Cytoskeleton

Total Cost €

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EC-Contrib. €

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Partnership

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 CellularLogistics project word cloud

Explore the words cloud of the CellularLogistics project. It provides you a very rough idea of what is the project "CellularLogistics" about.

polarity    uncover    map    complete    logistics    combine    proteins    revealing    preferred    mixed    motors    configurations    minus    polarization    either    unknown    transport    proper    resolve    networks    central    dendritic    structural    lab    mathematical    architectural    stability    modulate    mechanisms    dendrites    directed    directionality    selectively    intracellular    cytoskeleton    previously    cellular    microscopy    cell    orientations    explore    ways    3d    techniques    mt    modulates    morphology    form    positioning    determines    relation    mitotic    cells    dynamics    neurons    nevertheless    network    neuronal    functioning    ordered    technique    underlies    specialized    opposite    mts    biology    paint    organization    function    cytoskeletal    destinations    unravel    spindle    kinesins    create    plus    dynein    motor    modifications    utilized    remained    arrays    guides    organelles    anticipated    division    move    aid    revealed    molecular   

Project "CellularLogistics" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 2˙000˙000.00

Map

 Project objective

The organization and dynamics of the MT (MT) cytoskeleton underlies the morphology, polarization and division of most cells. The structural polarity of MT determines the directionality of motor proteins, which move selectively towards either the MT plus (most kinesins) or minus end (dynein) to control the transport and positioning of proteins and organelles. Understanding how different cellular MT arrays, such as the mitotic spindle or neuronal MT networks, are built and utilized to ensure proper cellular logistics is a central challenge in cell biology. Recently, our lab has introduced a new technique, motor-PAINT, to directly resolve MT polarity and the relation between MT orientations, stability and modifications. This revealed that in neurons, the mixed polarity MT network in the dendrites is much more ordered than previously anticipated. MTs with opposite orientations have different properties and are preferred by distinct kinesins, revealing an architectural principle that could explain why different plus-end directed motors move towards distinct destinations. Nevertheless, the mechanisms by which this specialized organization is established and the different ways in which it modulates intracellular transport have remained unknown. To resolve how cytoskeletal organization guides transport, I propose to explore the form, formation and functioning of the neuronal MT cytoskeleton. We will combine advanced microscopy, molecular biology, and mathematical modelling to: 1) Create a complete 3D map of the dendritic MT cytoskeleton – form. 2) Unravel the mechanisms that establish MT organization in dendrites – formation. 3) Explore how specific MT configurations modulate intracellular transport – function. This research will uncover key mechanisms of cytoskeletal organization and transport in neurons. In addition, our techniques and concepts will aid understanding intracellular transport in other cellular systems.

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The information about "CELLULARLOGISTICS" are provided by the European Opendata Portal: CORDIS opendata.

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