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CellularLogistics SIGNED

Cellular Logistics: Form, Formation and Function of the Neuronal Microtubule Cytoskeleton

Total Cost €

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EC-Contrib. €

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Partnership

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 CellularLogistics project word cloud

Explore the words cloud of the CellularLogistics project. It provides you a very rough idea of what is the project "CellularLogistics" about.

complete    map    intracellular    motors    technique    biology    division    cells    selectively    remained    combine    cellular    transport    logistics    organization    kinesins    underlies    polarity    neurons    either    preferred    mixed    modulates    proteins    3d    motor    functioning    mechanisms    cytoskeletal    spindle    directionality    ordered    morphology    previously    microscopy    orientations    dendritic    mts    revealed    utilized    mathematical    function    dendrites    central    dynein    lab    paint    mitotic    unravel    revealing    modulate    network    ways    structural    neuronal    organelles    opposite    plus    directed    dynamics    form    configurations    move    cell    proper    polarization    mt    molecular    architectural    networks    uncover    destinations    create    cytoskeleton    resolve    techniques    positioning    unknown    aid    guides    relation    explore    specialized    modifications    anticipated    arrays    nevertheless    minus    stability    determines   

Project "CellularLogistics" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 2˙000˙000.00

Map

 Project objective

The organization and dynamics of the MT (MT) cytoskeleton underlies the morphology, polarization and division of most cells. The structural polarity of MT determines the directionality of motor proteins, which move selectively towards either the MT plus (most kinesins) or minus end (dynein) to control the transport and positioning of proteins and organelles. Understanding how different cellular MT arrays, such as the mitotic spindle or neuronal MT networks, are built and utilized to ensure proper cellular logistics is a central challenge in cell biology. Recently, our lab has introduced a new technique, motor-PAINT, to directly resolve MT polarity and the relation between MT orientations, stability and modifications. This revealed that in neurons, the mixed polarity MT network in the dendrites is much more ordered than previously anticipated. MTs with opposite orientations have different properties and are preferred by distinct kinesins, revealing an architectural principle that could explain why different plus-end directed motors move towards distinct destinations. Nevertheless, the mechanisms by which this specialized organization is established and the different ways in which it modulates intracellular transport have remained unknown. To resolve how cytoskeletal organization guides transport, I propose to explore the form, formation and functioning of the neuronal MT cytoskeleton. We will combine advanced microscopy, molecular biology, and mathematical modelling to: 1) Create a complete 3D map of the dendritic MT cytoskeleton – form. 2) Unravel the mechanisms that establish MT organization in dendrites – formation. 3) Explore how specific MT configurations modulate intracellular transport – function. This research will uncover key mechanisms of cytoskeletal organization and transport in neurons. In addition, our techniques and concepts will aid understanding intracellular transport in other cellular systems.

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The information about "CELLULARLOGISTICS" are provided by the European Opendata Portal: CORDIS opendata.

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