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CellularLogistics SIGNED

Cellular Logistics: Form, Formation and Function of the Neuronal Microtubule Cytoskeleton

Total Cost €

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EC-Contrib. €

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Partnership

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 CellularLogistics project word cloud

Explore the words cloud of the CellularLogistics project. It provides you a very rough idea of what is the project "CellularLogistics" about.

unknown    relation    guides    utilized    cytoskeletal    directionality    networks    microscopy    form    function    architectural    cell    opposite    dendrites    nevertheless    mechanisms    remained    explore    underlies    either    paint    resolve    mitotic    stability    kinesins    polarity    transport    morphology    functioning    biology    plus    motors    neurons    division    specialized    cytoskeleton    cells    organelles    mathematical    create    central    selectively    lab    modulate    minus    map    dynein    anticipated    cellular    ordered    neuronal    mt    complete    configurations    positioning    organization    directed    revealed    proper    uncover    unravel    motor    proteins    mixed    revealing    aid    structural    dynamics    intracellular    logistics    mts    spindle    dendritic    preferred    modulates    molecular    network    destinations    move    previously    technique    techniques    modifications    orientations    ways    determines    combine    3d    polarization    arrays   

Project "CellularLogistics" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 2˙000˙000.00

Map

 Project objective

The organization and dynamics of the MT (MT) cytoskeleton underlies the morphology, polarization and division of most cells. The structural polarity of MT determines the directionality of motor proteins, which move selectively towards either the MT plus (most kinesins) or minus end (dynein) to control the transport and positioning of proteins and organelles. Understanding how different cellular MT arrays, such as the mitotic spindle or neuronal MT networks, are built and utilized to ensure proper cellular logistics is a central challenge in cell biology. Recently, our lab has introduced a new technique, motor-PAINT, to directly resolve MT polarity and the relation between MT orientations, stability and modifications. This revealed that in neurons, the mixed polarity MT network in the dendrites is much more ordered than previously anticipated. MTs with opposite orientations have different properties and are preferred by distinct kinesins, revealing an architectural principle that could explain why different plus-end directed motors move towards distinct destinations. Nevertheless, the mechanisms by which this specialized organization is established and the different ways in which it modulates intracellular transport have remained unknown. To resolve how cytoskeletal organization guides transport, I propose to explore the form, formation and functioning of the neuronal MT cytoskeleton. We will combine advanced microscopy, molecular biology, and mathematical modelling to: 1) Create a complete 3D map of the dendritic MT cytoskeleton – form. 2) Unravel the mechanisms that establish MT organization in dendrites – formation. 3) Explore how specific MT configurations modulate intracellular transport – function. This research will uncover key mechanisms of cytoskeletal organization and transport in neurons. In addition, our techniques and concepts will aid understanding intracellular transport in other cellular systems.

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The information about "CELLULARLOGISTICS" are provided by the European Opendata Portal: CORDIS opendata.

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