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TraffikGene SIGNED

Peptide Dynamic Amphiphiles for Gene Therapy and Macromolecular Delivery

Total Cost €

EC-Contrib. €

Partnership

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TraffikGene project word cloud

Explore the words cloud of the TraffikGene project. It provides you a very rough idea of what is the project "TraffikGene" about.

materials commercial ipr barrier constitutes macromolecules penetrating viral blood hydrophobic dynap rising transference stg customized human cargo identification brain scaffolds cytosolic industrial quick genetic financial commercialization connect stakeholders alternatives carefully cargos dynamic protection diversify glycans maximized methodology tails health diversification oligopeptides synthetic cationic nucleic transport antibody vectors peptide traffikgene aldehyde cell advantage acids mrna spin vehicles discoveries vitro polymer vivo strategy gene pegs employs platform clinical framework optimize therapy market niches licensing covalent libraries crossing exogenous macromolecular alternative bonds preliminary therapeutics off release encouraging erc constitute decided confirms tools

Project "TraffikGene" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-PoC
Funding Scheme	ERC-POC
Starting year	2019
Duration (year-month-day)	from 2019-07-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	coordinator	150˙000.00

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Project objective

The delivery of exogenous nucleic acids and related macromolecules is one of the most encouraging tools for the future of human health. However, the delivery of the required genetic cargo still constitutes an important challenge. Although non-viral vectors are still in their preliminary clinical steps they are rising up as a real alternative for gene therapeutics. Oligopeptides and polymer cell penetrating materials constitute one of the most promising alternatives for the protection, transport and controlled release of different macromolecular cargos. Under the framework of the ERC-Stg_DYNAP we have methodology that employs dynamic covalent bonds to connect peptide/polymer scaffolds with different aldehyde tails (cationic, hydrophobic, glycans, PEGs, etc.). This key synthetic advantage allows the quick identification of different peptide vehicles for customized cargos. The recent interest of important industrial partners in our technology confirms the strong interest and potential impact of our platform. TraffikGene will diversify the potential market applications of this technology and will allow us to reach a higher level of control for the market transference. We will optimize peptide libraries for the delivery of new nucleic acids (i.e. mRNA) in in vitro and in vivo. The potential commercial success will be maximized by diversification of the applications in gene therapy, cytosolic delivery, antibody transport, cell targeting, blood brain barrier crossing, etc. A market analysis will identify industrial needs, market niches, financial requirements and stakeholders for commercialization. The best future IPR strategy will be carefully evaluated and decided (i.e. product licensing, product development, spin-off, etc.). TraffikGene will allow us to identify and solve challenges required to improve, diversify and exploit the strong potential market applications of our discoveries in the field of gene and macromolecular controlled delivery.

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The information about "TRAFFIKGENE" are provided by the European Opendata Portal: CORDIS opendata.