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TraffikGene SIGNED

Peptide Dynamic Amphiphiles for Gene Therapy and Macromolecular Delivery

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TraffikGene project word cloud

Explore the words cloud of the TraffikGene project. It provides you a very rough idea of what is the project "TraffikGene" about.

materials    commercial    ipr    barrier    constitutes    macromolecules    penetrating    viral    blood    hydrophobic    dynap    rising    transference    stg    customized    human    cargo    identification    brain    scaffolds    cytosolic    industrial    quick    genetic    financial    commercialization    connect    stakeholders    alternatives    carefully    cargos    dynamic    protection    diversify    glycans    maximized    methodology    tails    health    diversification    oligopeptides    synthetic    cationic    nucleic    transport    antibody    vectors    peptide    traffikgene    aldehyde    cell    advantage    acids    mrna    spin    vehicles    discoveries    vitro    polymer    vivo    strategy    gene    pegs    employs    platform    clinical    framework    optimize    therapy    market    niches    licensing    covalent    libraries    crossing    exogenous    macromolecular    alternative    bonds    preliminary    therapeutics    off    release    encouraging    erc    constitute    decided    confirms    tools   

Project "TraffikGene" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA 

Organization address
address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
city: SANTIAGO DE COMPOSTELA
postcode: 15782
website: http://www.usc.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) coordinator 150˙000.00

Map

 Project objective

The delivery of exogenous nucleic acids and related macromolecules is one of the most encouraging tools for the future of human health. However, the delivery of the required genetic cargo still constitutes an important challenge. Although non-viral vectors are still in their preliminary clinical steps they are rising up as a real alternative for gene therapeutics. Oligopeptides and polymer cell penetrating materials constitute one of the most promising alternatives for the protection, transport and controlled release of different macromolecular cargos. Under the framework of the ERC-Stg_DYNAP we have methodology that employs dynamic covalent bonds to connect peptide/polymer scaffolds with different aldehyde tails (cationic, hydrophobic, glycans, PEGs, etc.). This key synthetic advantage allows the quick identification of different peptide vehicles for customized cargos. The recent interest of important industrial partners in our technology confirms the strong interest and potential impact of our platform. TraffikGene will diversify the potential market applications of this technology and will allow us to reach a higher level of control for the market transference. We will optimize peptide libraries for the delivery of new nucleic acids (i.e. mRNA) in in vitro and in vivo. The potential commercial success will be maximized by diversification of the applications in gene therapy, cytosolic delivery, antibody transport, cell targeting, blood brain barrier crossing, etc. A market analysis will identify industrial needs, market niches, financial requirements and stakeholders for commercialization. The best future IPR strategy will be carefully evaluated and decided (i.e. product licensing, product development, spin-off, etc.). TraffikGene will allow us to identify and solve challenges required to improve, diversify and exploit the strong potential market applications of our discoveries in the field of gene and macromolecular controlled delivery.

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The information about "TRAFFIKGENE" are provided by the European Opendata Portal: CORDIS opendata.

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