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SCAMPICITY SIGNED

cAMP-dependend plasticity of striatal projection neurons in health and disease

Total Cost €

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EC-Contrib. €

0

Partnership

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 SCAMPICITY project word cloud

Explore the words cloud of the SCAMPICITY project. It provides you a very rough idea of what is the project "SCAMPICITY" about.

cascade    pd    neurons    structural    elevate    data    model    animal    mediated    dspns    messenger    ispns    look    activates    corticostriatal    vivo    motor    ask    levels    disorder    weakening    coupled    transient    activation    induce    synapse    relates    sufficient    preferentially    secondly    unravel    express    groups    inform    spiny    death    aberrant    untested    potentiated    strategies    subgroups    spns    treatments    inhibits    divide    unpublished    protocols    spines    transmission    striatum    alone    projection    reveal    altered    optogenetic    potentially    drug    subsequent    lastly    striatal    health    resolution    parkinson    plasticity    symptoms    signaling    cell    opposite    camp    spn    spatiotemporal    interrupted    lack    leads    d1    suggest    receptor    combat    d2    unraveling    synaptic    caused    notion    responsiveness    neurodegenerative    dendritic    dopamine    unknown    disease    precise    da    presumably    tools   

Project "SCAMPICITY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

Organization address
address: Martinistrasse 52
city: HAMBURG
postcode: 20251
website: www.uke.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) coordinator 174˙806.00

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 Project objective

The project aims to reveal the so far unknown role of cAMP in structural and synaptic plasticity of striatal spiny projection neurons (SPNs) in health and disease. Striatal SPNs divide into two subgroups: the dSPNs and iSPNs. While dSPNs preferentially express the D1 dopamine (DA) receptor, iSPNs express the D2 receptor. Both are coupled to the cAMP second messenger cascade, however the D1-receptor activates and the D2-receptor inhibits it. DA has therefore opposite effects on the two SPN groups, both mediated by cAMP. Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It is characterized by typical motor symptoms caused by the death of DA neurons and the subsequent lack of DA in the striatum. A long-standing but untested notion in the field is that loss of DA leads to aberrant cAMP levels and signaling in SPNs. The project will look at the role of cAMP in SPN synaptic and structural plasticity. We will use novel optogenetic tools that allow cell-type specific activation of cAMP, with high spatiotemporal resolution. Focusing on corticostriatal synaptic transmission, we want to ask if transient activation of cAMP alone is sufficient to induce plasticity (e.g. strengthening or weakening) of this synapse. Secondly, we will use known plasticity protocols and test if precise activation of cAMP can interrupted or potentiated them. Unpublished data suggest that in vivo drug treatments that presumably elevate cAMP in SPNs induce structural plasticity, i.e. loss of dendritic spines. Following this we will unravel if cell-type specific activation of cAMP is sufficient to induce structural changes and how this relates to synaptic plasticity. Lastly, we will test the long-standing notion that cAMP levels and the responsiveness of the cascade are altered in an animal model of PD. This project will advance our understanding of how SPNs work by unraveling cAMP’s role in plasticity, and potentially inform future strategies to combat PD.

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The information about "SCAMPICITY" are provided by the European Opendata Portal: CORDIS opendata.

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