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SCAMPICITY SIGNED

cAMP-dependend plasticity of striatal projection neurons in health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SCAMPICITY project word cloud

Explore the words cloud of the SCAMPICITY project. It provides you a very rough idea of what is the project "SCAMPICITY" about.

unraveling    sufficient    transmission    reveal    structural    opposite    tools    responsiveness    signaling    symptoms    induce    subsequent    death    altered    disorder    inhibits    secondly    optogenetic    precise    dendritic    preferentially    disease    untested    d2    animal    levels    striatum    aberrant    spiny    groups    strategies    ispns    neurodegenerative    corticostriatal    parkinson    motor    relates    protocols    potentially    vivo    look    activates    combat    messenger    subgroups    unknown    data    synaptic    camp    synapse    leads    pd    drug    potentiated    cell    resolution    spines    presumably    express    spatiotemporal    da    projection    dspns    interrupted    activation    model    treatments    striatal    spn    coupled    mediated    unravel    notion    dopamine    ask    suggest    plasticity    inform    neurons    health    elevate    cascade    caused    receptor    alone    lastly    transient    d1    lack    unpublished    spns    divide    weakening   

Project "SCAMPICITY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

Organization address
address: Martinistrasse 52
city: HAMBURG
postcode: 20251
website: www.uke.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) coordinator 174˙806.00

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 Project objective

The project aims to reveal the so far unknown role of cAMP in structural and synaptic plasticity of striatal spiny projection neurons (SPNs) in health and disease. Striatal SPNs divide into two subgroups: the dSPNs and iSPNs. While dSPNs preferentially express the D1 dopamine (DA) receptor, iSPNs express the D2 receptor. Both are coupled to the cAMP second messenger cascade, however the D1-receptor activates and the D2-receptor inhibits it. DA has therefore opposite effects on the two SPN groups, both mediated by cAMP. Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It is characterized by typical motor symptoms caused by the death of DA neurons and the subsequent lack of DA in the striatum. A long-standing but untested notion in the field is that loss of DA leads to aberrant cAMP levels and signaling in SPNs. The project will look at the role of cAMP in SPN synaptic and structural plasticity. We will use novel optogenetic tools that allow cell-type specific activation of cAMP, with high spatiotemporal resolution. Focusing on corticostriatal synaptic transmission, we want to ask if transient activation of cAMP alone is sufficient to induce plasticity (e.g. strengthening or weakening) of this synapse. Secondly, we will use known plasticity protocols and test if precise activation of cAMP can interrupted or potentiated them. Unpublished data suggest that in vivo drug treatments that presumably elevate cAMP in SPNs induce structural plasticity, i.e. loss of dendritic spines. Following this we will unravel if cell-type specific activation of cAMP is sufficient to induce structural changes and how this relates to synaptic plasticity. Lastly, we will test the long-standing notion that cAMP levels and the responsiveness of the cascade are altered in an animal model of PD. This project will advance our understanding of how SPNs work by unraveling cAMP’s role in plasticity, and potentially inform future strategies to combat PD.

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The information about "SCAMPICITY" are provided by the European Opendata Portal: CORDIS opendata.

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