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MechanoGenetic SIGNED

Role of mechanical forces in cell-matrix adhesion sites

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MechanoGenetic project word cloud

Explore the words cloud of the MechanoGenetic project. It provides you a very rough idea of what is the project "MechanoGenetic" about.

suitable    organisation    mechanotransmission    muscular    discover    cell    adhesions    integrin    organism    transmitted    deeper    framework    genetic    utilizing    tweezers    biosensors    contractility    elevated    extracellular    fret    group    embryo    junctions    adhesome    striking    magnetic    mechanosensor    integrate    mechanical    certain    muscle    tissues    combining    matrix    critical    networks    constantly    combat    threshold    forces    integrity    adhesion    tissue    modulate    tension    outcome    binding    similarities    vivo    laser    either    sense    microenvironment    talin    ecm    first    quantify    diseases    dissociated    interdisciplinary    bodies    lose    adhesive    complementary    biophysical    molecular    drosophila    human    function    healthily    module    core    strength    living    alters    mutants    dystrophic    fly    ipp    relationship    examine    ablation    mechanosensing    cells    myotendinous    collectively    hold    tight    dystrophies   

Project "MechanoGenetic" data sheet

The following table provides information about the project.

Coordinator
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON 

Organization address
address: SORANOU EFESIOU 4
city: ATHINA
postcode: 115 27
website: www.bioacademy.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 153˙085 €
 EC max contribution 153˙085 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) coordinator 153˙085.00

Map

 Project objective

Cells in our bodies constantly experience mechanical forces from their microenvironment. When cells sense a critical threshold of elevated tension, they hold tight together and allow tissues to function healthily as a group. In certain diseases, however, our cells lose their mechanosensing and adhesive properties and, as a result they get dissociated, as in the case of muscular dystrophies. Integrin-based adhesions to the extracellular matrix (ECM) are emerging as key networks of mechanotransmission. This proposal aims to discover how mechanical forces modulate cell-matrix adhesion at the myotendinous junctions in the developing Drosophila embryo, combining biophysical, molecular and genetic approaches. To achieve this goal, I propose to implement two complementary specific objectives: First, I will identify and quantify the relationship between forces and adhesion strength in mutants affecting either integrin-ECM binding or muscle contractility by utilizing in vivo laser ablation and magnetic tweezers. Second, I will examine whether and how IPP complex -a core module of the integrin adhesome- alters the molecular forces transmitted across Talin, which is a major mechanosensor at integrin junctions, utilizing suitable FRET-based biosensors. Collectively, this interdisciplinary research will provide a novel mechanical framework of how cells integrate forces and maintain tissue integrity in the living organism. Given the striking similarities in the molecular organisation of the myotendinous junctions between fly and human, the outcome of this work will provide a deeper understanding of how we can better combat dystrophic diseases.

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