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MechanoGenetic SIGNED

Role of mechanical forces in cell-matrix adhesion sites

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MechanoGenetic project word cloud

Explore the words cloud of the MechanoGenetic project. It provides you a very rough idea of what is the project "MechanoGenetic" about.

vivo    complementary    cells    adhesive    group    modulate    discover    dissociated    muscle    function    tight    dystrophies    ipp    fly    outcome    extracellular    magnetic    integrin    tissues    integrate    first    mutants    junctions    drosophila    microenvironment    human    integrity    constantly    adhesion    hold    tension    binding    healthily    diseases    contractility    suitable    embryo    strength    tweezers    mechanosensor    critical    certain    dystrophic    biophysical    utilizing    ablation    threshold    combat    organism    combining    genetic    striking    forces    core    mechanosensing    fret    interdisciplinary    lose    quantify    organisation    mechanotransmission    biosensors    laser    talin    framework    networks    examine    cell    matrix    alters    mechanical    either    adhesome    elevated    ecm    living    collectively    molecular    adhesions    bodies    transmitted    tissue    similarities    sense    relationship    deeper    myotendinous    muscular    module   

Project "MechanoGenetic" data sheet

The following table provides information about the project.

Coordinator
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON 

Organization address
address: SORANOU EFESIOU 4
city: ATHINA
postcode: 115 27
website: www.bioacademy.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 153˙085 €
 EC max contribution 153˙085 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) coordinator 153˙085.00

Map

 Project objective

Cells in our bodies constantly experience mechanical forces from their microenvironment. When cells sense a critical threshold of elevated tension, they hold tight together and allow tissues to function healthily as a group. In certain diseases, however, our cells lose their mechanosensing and adhesive properties and, as a result they get dissociated, as in the case of muscular dystrophies. Integrin-based adhesions to the extracellular matrix (ECM) are emerging as key networks of mechanotransmission. This proposal aims to discover how mechanical forces modulate cell-matrix adhesion at the myotendinous junctions in the developing Drosophila embryo, combining biophysical, molecular and genetic approaches. To achieve this goal, I propose to implement two complementary specific objectives: First, I will identify and quantify the relationship between forces and adhesion strength in mutants affecting either integrin-ECM binding or muscle contractility by utilizing in vivo laser ablation and magnetic tweezers. Second, I will examine whether and how IPP complex -a core module of the integrin adhesome- alters the molecular forces transmitted across Talin, which is a major mechanosensor at integrin junctions, utilizing suitable FRET-based biosensors. Collectively, this interdisciplinary research will provide a novel mechanical framework of how cells integrate forces and maintain tissue integrity in the living organism. Given the striking similarities in the molecular organisation of the myotendinous junctions between fly and human, the outcome of this work will provide a deeper understanding of how we can better combat dystrophic diseases.

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The information about "MECHANOGENETIC" are provided by the European Opendata Portal: CORDIS opendata.

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