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AmygdalaNeuroMod SIGNED

Unraveling the combinatorial logic of amygdala neuromodulation in decision-making and learning.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AmygdalaNeuroMod project word cloud

Explore the words cloud of the AmygdalaNeuroMod project. It provides you a very rough idea of what is the project "AmygdalaNeuroMod" about.

dopamine    network    foundations    neuromodulator    depends    salience    group    neuromodulators    cell    core    mood    neuromodulatory    reward    record    combine    brain    serotonin    physiological    host    circuit    released    neuronal    disorders    amygdala    career    functional    norepinephrine    expand    almost    elucidating    function    depression    interplay    disorder    imbalance    mental    europeans    context    me    alterations    behavioral    little    regulates    stimuli    genetic    synaptic    electrophysiology    proper    holds    decision    leader    ranging    manipulate    fundamentally    laboratory    types    opportunity    keys    tools    neurotechnologies    fellowship    logic    regions    emotional    inputs    critical    interactions    circuitry    sub    simultaneously    expertise    threat    basic    learning    acetylcholine    circuits    surprisingly    independent    region    plays    neurotransmitters    mice    neuromodulation    guided    innervated    treating    balance    behaving    modern    anxiety   

Project "AmygdalaNeuroMod" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 191˙149 €
 EC max contribution 191˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 191˙149.00

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 Project objective

Proper neuronal circuit function depends fundamentally on the balance of neuromodulators, a set of neurotransmitters released widely throughout the brain. Almost every mental disorder, including anxiety and depression, that affect one out of four Europeans, are associated with a neuromodulatory imbalance in specific sub-circuits. Elucidating the role of different neuromodulatory inputs to specific brain regions holds the keys to understanding and treating mood disorders.

The amygdala plays an essential role in the processing of emotional stimuli and salience, ranging from reward to threat and synaptic alterations in this region are critical for learning and emotional processing. Amygdala is innervated by every major neuromodulator, yet surprisingly little is known about the activity of these inputs under physiological conditions and how neuromodulation regulates amygdala circuit activity during different behavioral states and learning.

Here, I propose to study the functional role of neuromodulatory inputs to the amygdala circuitry during learning and decision-making. Towards this goal, I will combine my experience in large-scale electrophysiology with the expertise of the host laboratory in modern genetic tools and neurotechnologies to simultaneously record and manipulate the activity of dopamine, serotonin, norepinephrine and acetylcholine inputs to the amygdala during context-guided decision-making in behaving mice. Using this approach, I aim to characterize the logic of interactions between neuromodulators and its implementation at the level of defined circuits and cell types in the amygdala and to demonstrate the role of this coordination in defining network activity, behavioral state and learning.

The fellowship will contribute to our basic understanding of the interplay between two core brain systems, while it will provide me with a unique opportunity to expand my expertise and establish the foundations of my future career as an independent group leader.

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The information about "AMYGDALANEUROMOD" are provided by the European Opendata Portal: CORDIS opendata.

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