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BCLLatlas SIGNED

Single-cell genomics to comprehensively understand healthy B-cell maturation and transformation to chronic lymphocytic leukemia

Total Cost €

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EC-Contrib. €

0

Partnership

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 BCLLatlas project word cloud

Explore the words cloud of the BCLLatlas project. It provides you a very rough idea of what is the project "BCLLatlas" about.

pathology    disease    leukemic    medicine    cellular    epigenetic    aggressiveness    hundred    las    maps    clonal    goals    stages    origin    dynamics    genomics    diagnosis    course    generating    computational    implications    transformation    biology    normal    unprecedented    treatment    entire    diversity    healthy    subclonal    cell    genetic    richness    architecture    precision    proliferations    expertise    groups    initial    lymphocytic    generate    revolutionizing    leukemia    atlas    complementary    subclonality    decipher    cells    revealed    deciphering    sequencing    anatomy    minute    cancer    locations    evolution    bcll    teams    cll    last    subtypes    thousands    fulfill    profiling    single    analytical    pools    epigenomics    individuals    unbiased    points    modulated    transcriptional    western    world    understand    subpopulations    clinics    transcriptomics    era    samples    deep    history    monoclonal    plan    neoplastic    time    chronic    technologies    insights    scenario    maturation    frequent    molecular    differentiation    dynamically    life    clinical   

Project "BCLLatlas" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO CENTRE DE REGULACIO GENOMICA 

Organization address
address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003
website: www.crg.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 8˙333˙331 €
 EC max contribution 8˙333˙331 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) coordinator 5˙451˙231.00
2    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER ES (BARCELONA) participant 2˙882˙100.00

Map

 Project objective

Unbiased analyses of the molecular make up of single cells are revolutionizing our understanding of cell differentiation and cancer. Over the last years, our groups have characterized the molecular features of normal B-cell subpopulations and of pools of leukemic cells from chronic lymphocytic leukemia (CLL), the most frequent leukemia in the Western world. These analyses have revealed that CLL subtypes are related to different B-cell maturation stages, and that they can show a complex subclonal architecture. Such subclonality is dynamically modulated during the course of the disease, and has deep implications in CLL biology, clinical aggressiveness and treatment responses. In this scenario, BCLL@las aims at deciphering the origin and molecular anatomy of CLL during the entire life history of the disease by generating genetic, transcriptional and epigenetic maps of hundred-thousands of single cells across locations, time points and individuals. We plan to fulfill four major objectives: 1) To generate a comprehensive atlas of normal B-cell maturation, 2) To understand the initial steps of neoplastic transformation through the analysis of minute B-cell monoclonal proliferations in healthy individuals, 3) To decipher the cellular diversity and clonal architecture of CLL at diagnosis, and 4) To characterize the single-cell subclonal dynamics of CLL during disease evolution and treatment response. To reach these goals, BCLL@las gathers together four teams with complementary expertise in B-cell biology, clinics and pathology of CLL, genomics, transcriptomics, epigenomics, sequencing technologies, single-cell profiling and computational biology. This, together with the richness of the available CLL samples and the technical and analytical depth of BCLL@las shall lead to unprecedented insights into the origin and evolution of cancer in the precision medicine era.

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The information about "BCLLATLAS" are provided by the European Opendata Portal: CORDIS opendata.

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