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BCLLatlas SIGNED

Single-cell genomics to comprehensively understand healthy B-cell maturation and transformation to chronic lymphocytic leukemia

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 BCLLatlas project word cloud

Explore the words cloud of the BCLLatlas project. It provides you a very rough idea of what is the project "BCLLatlas" about.

leukemic    cells    subtypes    sequencing    evolution    implications    cell    subpopulations    clinical    diagnosis    epigenomics    life    revolutionizing    dynamically    samples    expertise    leukemia    technologies    subclonal    analytical    hundred    neoplastic    thousands    revealed    diversity    locations    monoclonal    understand    single    genomics    architecture    genetic    transcriptomics    aggressiveness    treatment    molecular    maps    bcll    insights    chronic    biology    precision    world    cll    era    proliferations    goals    unbiased    transcriptional    lymphocytic    complementary    fulfill    subclonality    disease    pathology    differentiation    clinics    epigenetic    initial    time    teams    groups    maturation    atlas    stages    medicine    computational    cellular    generate    plan    history    dynamics    modulated    frequent    minute    richness    transformation    last    deciphering    origin    generating    scenario    entire    clonal    western    pools    deep    las    points    healthy    normal    cancer    anatomy    profiling    course    individuals    decipher    unprecedented   

Project "BCLLatlas" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO CENTRE DE REGULACIO GENOMICA 

Organization address
address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003
website: www.crg.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 8˙333˙331 €
 EC max contribution 8˙333˙331 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) coordinator 5˙451˙231.00
2    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER ES (BARCELONA) participant 2˙882˙100.00

Map

 Project objective

Unbiased analyses of the molecular make up of single cells are revolutionizing our understanding of cell differentiation and cancer. Over the last years, our groups have characterized the molecular features of normal B-cell subpopulations and of pools of leukemic cells from chronic lymphocytic leukemia (CLL), the most frequent leukemia in the Western world. These analyses have revealed that CLL subtypes are related to different B-cell maturation stages, and that they can show a complex subclonal architecture. Such subclonality is dynamically modulated during the course of the disease, and has deep implications in CLL biology, clinical aggressiveness and treatment responses. In this scenario, BCLL@las aims at deciphering the origin and molecular anatomy of CLL during the entire life history of the disease by generating genetic, transcriptional and epigenetic maps of hundred-thousands of single cells across locations, time points and individuals. We plan to fulfill four major objectives: 1) To generate a comprehensive atlas of normal B-cell maturation, 2) To understand the initial steps of neoplastic transformation through the analysis of minute B-cell monoclonal proliferations in healthy individuals, 3) To decipher the cellular diversity and clonal architecture of CLL at diagnosis, and 4) To characterize the single-cell subclonal dynamics of CLL during disease evolution and treatment response. To reach these goals, BCLL@las gathers together four teams with complementary expertise in B-cell biology, clinics and pathology of CLL, genomics, transcriptomics, epigenomics, sequencing technologies, single-cell profiling and computational biology. This, together with the richness of the available CLL samples and the technical and analytical depth of BCLL@las shall lead to unprecedented insights into the origin and evolution of cancer in the precision medicine era.

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The information about "BCLLATLAS" are provided by the European Opendata Portal: CORDIS opendata.

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