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Foldmetcat SIGNED

Bioinspired Catalytic Metallofoldamers

Total Cost €

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EC-Contrib. €

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Partnership

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 Foldmetcat project word cloud

Explore the words cloud of the Foldmetcat project. It provides you a very rough idea of what is the project "Foldmetcat" about.

generate    cavitant    inherent    first    unconventional    larger    centers    fundamental    metal    translocation    fold    chemistry    carbenes    polyenes    arrangement    series    substrate    zinc    donor    efficient    bond    carbocation    cyclase    reactivity    delineate    transition    structurally    containing    close    carbocyclic    initiated    c2    inspired    metallic    intramolecular    terpenoid    chiral    resorcinarene    prototypes    single    types    cascades    reaction    ophiobolin    intrinsic    enzymes    mimicking    digold    activation    folding    heterocyclic    activate    catalytic    enantioselectively    rooted    skeletons    clusters    taxol    purpose    modes    polyenynes    heterobimetallic    cyclizations    organometallic    attain    catalysts    simultaneously    cyclization    complexes    supramolecular    phosphonite    polyunsaturated    initial    hydrogen    substrates    paradigm    ligands    reactive    anion    distant    site    pairing    stereogenic    diphosphines    sites    prepare    unprecedented    explore    mixed    metals    electrophilic    gold   

Project "Foldmetcat" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 2˙500˙000.00

Map

 Project objective

Inspired by mimicking the characteristics of terpenoid cyclase enzymes, the goal of this proposal is to design new types of catalysts containing electrophilic transition metal centers that could simultaneously fold and activate polyunsaturated substrates promoting non-inherent cyclization modes. Our goal is unprecedented, although it is rooted on fundamental organometallic chemistry, in particular, on the known activation of polyunsaturated substrates by highly electrophilic transition metals. These unconventional cyclizations cascades challenge the paradigm that the intrinsic reactivity of the substrate is the relevant factor in carbocation-initiated processes and would provide access to large carbocyclic skeletons such as those present in taxol and ophiobolin enantioselectively in a single step under catalytic conditions. Although the initial work will be carried out with gold catalysts, a major goal of this research is to develop other general-purpose efficient chiral electrophilic catalysts based on zinc. To attain our goal, we will study more simple catalysts to delineate the factors that control the folding of polyenynes and polyenes. Thus, we will prepare new series of C2-chiral catalysts in which the stereogenic elements are close to the reaction site. Related C2-chiral systems will be generated by supramolecular hydrogen-bond pairing. A similar chiral arrangement could also be achieved by an intramolecular chiral anion translocation from the metal to a distant hydrogen-bond donor site. In addition, we will explore larger systems based on structurally well-defined metallic clusters to generate highly electrophilic chiral reactive sites. The folding and activation of polyunsaturated substrates will be studied first with a series of catalytic prototypes based on digold or heterobimetallic complexes with N-heterocyclic carbenes, diphosphines, mixed ligands of these types, as well as resorcinarene-phosphonite cavitant ligands.

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The information about "FOLDMETCAT" are provided by the European Opendata Portal: CORDIS opendata.

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