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Foldmetcat SIGNED

Bioinspired Catalytic Metallofoldamers

Total Cost €

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EC-Contrib. €

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Partnership

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 Foldmetcat project word cloud

Explore the words cloud of the Foldmetcat project. It provides you a very rough idea of what is the project "Foldmetcat" about.

terpenoid    modes    heterocyclic    skeletons    mimicking    initial    containing    inspired    resorcinarene    generate    cavitant    polyenes    types    activation    unprecedented    c2    fold    explore    anion    first    supramolecular    series    donor    electrophilic    translocation    chiral    enantioselectively    carbocation    paradigm    stereogenic    heterobimetallic    initiated    delineate    hydrogen    intrinsic    purpose    zinc    simultaneously    close    diphosphines    clusters    catalytic    folding    substrate    carbocyclic    rooted    cyclase    prototypes    reactive    organometallic    inherent    activate    cyclization    gold    catalysts    phosphonite    enzymes    fundamental    prepare    unconventional    metal    metals    metallic    complexes    taxol    sites    intramolecular    arrangement    digold    ligands    attain    site    centers    bond    ophiobolin    reaction    substrates    transition    larger    distant    polyenynes    cyclizations    mixed    chemistry    polyunsaturated    efficient    cascades    reactivity    carbenes    pairing    structurally    single   

Project "Foldmetcat" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 2˙500˙000.00

Map

 Project objective

Inspired by mimicking the characteristics of terpenoid cyclase enzymes, the goal of this proposal is to design new types of catalysts containing electrophilic transition metal centers that could simultaneously fold and activate polyunsaturated substrates promoting non-inherent cyclization modes. Our goal is unprecedented, although it is rooted on fundamental organometallic chemistry, in particular, on the known activation of polyunsaturated substrates by highly electrophilic transition metals. These unconventional cyclizations cascades challenge the paradigm that the intrinsic reactivity of the substrate is the relevant factor in carbocation-initiated processes and would provide access to large carbocyclic skeletons such as those present in taxol and ophiobolin enantioselectively in a single step under catalytic conditions. Although the initial work will be carried out with gold catalysts, a major goal of this research is to develop other general-purpose efficient chiral electrophilic catalysts based on zinc. To attain our goal, we will study more simple catalysts to delineate the factors that control the folding of polyenynes and polyenes. Thus, we will prepare new series of C2-chiral catalysts in which the stereogenic elements are close to the reaction site. Related C2-chiral systems will be generated by supramolecular hydrogen-bond pairing. A similar chiral arrangement could also be achieved by an intramolecular chiral anion translocation from the metal to a distant hydrogen-bond donor site. In addition, we will explore larger systems based on structurally well-defined metallic clusters to generate highly electrophilic chiral reactive sites. The folding and activation of polyunsaturated substrates will be studied first with a series of catalytic prototypes based on digold or heterobimetallic complexes with N-heterocyclic carbenes, diphosphines, mixed ligands of these types, as well as resorcinarene-phosphonite cavitant ligands.

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The information about "FOLDMETCAT" are provided by the European Opendata Portal: CORDIS opendata.

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