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Foldmetcat SIGNED

Bioinspired Catalytic Metallofoldamers

Total Cost €

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EC-Contrib. €

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Partnership

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 Foldmetcat project word cloud

Explore the words cloud of the Foldmetcat project. It provides you a very rough idea of what is the project "Foldmetcat" about.

mixed    ophiobolin    phosphonite    intrinsic    purpose    complexes    terpenoid    catalytic    rooted    delineate    inspired    reactive    translocation    electrophilic    sites    activate    containing    chiral    clusters    stereogenic    fold    metals    generate    organometallic    substrate    reaction    heterocyclic    transition    enantioselectively    paradigm    polyenynes    structurally    anion    digold    initiated    close    series    explore    hydrogen    attain    chemistry    single    gold    ligands    folding    fundamental    efficient    mimicking    skeletons    prototypes    carbenes    resorcinarene    diphosphines    prepare    simultaneously    bond    c2    taxol    initial    catalysts    heterobimetallic    cascades    polyenes    reactivity    zinc    unconventional    metal    centers    cavitant    polyunsaturated    metallic    unprecedented    cyclization    cyclizations    modes    distant    cyclase    enzymes    first    carbocyclic    arrangement    larger    inherent    pairing    supramolecular    activation    carbocation    types    intramolecular    donor    site    substrates   

Project "Foldmetcat" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 2˙500˙000.00

Map

 Project objective

Inspired by mimicking the characteristics of terpenoid cyclase enzymes, the goal of this proposal is to design new types of catalysts containing electrophilic transition metal centers that could simultaneously fold and activate polyunsaturated substrates promoting non-inherent cyclization modes. Our goal is unprecedented, although it is rooted on fundamental organometallic chemistry, in particular, on the known activation of polyunsaturated substrates by highly electrophilic transition metals. These unconventional cyclizations cascades challenge the paradigm that the intrinsic reactivity of the substrate is the relevant factor in carbocation-initiated processes and would provide access to large carbocyclic skeletons such as those present in taxol and ophiobolin enantioselectively in a single step under catalytic conditions. Although the initial work will be carried out with gold catalysts, a major goal of this research is to develop other general-purpose efficient chiral electrophilic catalysts based on zinc. To attain our goal, we will study more simple catalysts to delineate the factors that control the folding of polyenynes and polyenes. Thus, we will prepare new series of C2-chiral catalysts in which the stereogenic elements are close to the reaction site. Related C2-chiral systems will be generated by supramolecular hydrogen-bond pairing. A similar chiral arrangement could also be achieved by an intramolecular chiral anion translocation from the metal to a distant hydrogen-bond donor site. In addition, we will explore larger systems based on structurally well-defined metallic clusters to generate highly electrophilic chiral reactive sites. The folding and activation of polyunsaturated substrates will be studied first with a series of catalytic prototypes based on digold or heterobimetallic complexes with N-heterocyclic carbenes, diphosphines, mixed ligands of these types, as well as resorcinarene-phosphonite cavitant ligands.

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The information about "FOLDMETCAT" are provided by the European Opendata Portal: CORDIS opendata.

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