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PROTEAS SIGNED

Programming Terpene Cyclization Through Iterative Precursor Assembly

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "PROTEAS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 260˙840 €
 EC max contribution 260˙840 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 260˙840.00
2    THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS US (CHAMPAIGN) partner 0.00

Map

 Project objective

Recent advances in the development of iterative synthetic methodology (“assembly-line synthesis”) have the potential to bring about a paradigm shift in small molecule synthesis, by providing automated protocols similar to those used for oligopeptide and oligonucleotide synthesis. However, a clear limitation of such systems has been the synthesis of topologically complex frameworks. Drawing inspiration from Nature, this project aims to address this issue by providing an innovative protocol for the automated synthesis of complex natural product-like scaffolds. This will be done by combining two cutting-edge methodologies: (i) the automated synthetic platform developed by the Burke group in the University of Illinois at Urbana-Champaign, which can rapidly provide libraries of small molecules by the iterative coupling of N-methyliminodiacetic acid (MIDA) boronate building blocks, and (ii) a novel supramolecular capsule catalyst developed by the Tiefenbacher group at the University of Basel, which has the unique capability to catalyse the tail-to-head terpene cyclization, the same transformation employed by Nature to give rise to the myriad of known terpene structures. The Burke group’s small molecule synthesizer will thus be used to rapidly assemble linear terpenoid precursors, which will then be subjected to tail-to-head terpene cyclization via the Tiefenbacher group’s catalyst to form cyclized terpenoid structures. The project will identify factors that influence the course of the cyclization and develop methods to control it so that desired scaffolds are produced on-demand. At its conclusion, it aims to provide a platform for the automated preparation of natural product-like compounds that will greatly impact chemical biology and medicinal chemistry research.

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The information about "PROTEAS" are provided by the European Opendata Portal: CORDIS opendata.

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