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EndoPos SIGNED

Endosome positioning in tumour-stroma interactions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EndoPos project word cloud

Explore the words cloud of the EndoPos project. It provides you a very rough idea of what is the project "EndoPos" about.

guides    ovarian    receptors    cell    contributes    lethal    context    rab11    tumour    positioned    combining    live    metastatic    innovative    invasive    imaging    trafficking    expertise    cancer    plays    form    serous    cutting    relevance    stroma    cells    coordinates    40    localised    combination    relapse    magnetogenetic    protein    signaling    endocytic    rho    progression    surface    reposition    labelling    independent    integrins    worst    therapies    dynamics    extracellular    proximity    mechanistic    manipulate    host    matrix    proteomics    interactions    researcher    engineering    controls    lethality    clinical    recycling    metastasis    protrusions    elucidate    rates    lt    skills    functions    molecular    actively    accumulate    despite    gtpases    regulate    polymerization    aggressiveness    migration    endocytosis    actin    promotes    invading    suppressing    proliferation    acquire    me    niche    family    polarized    clear    physiological    positive    grade    differentiation    machinery    endosomes    surroundings    hgsoc    lab    preventing    lend    survival    carcinoma    edge    bioid    observations   

Project "EndoPos" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 224˙933.00

Map

 Project objective

Endocytosis of cell surface receptors controls signaling during proliferation, differentiation and migration of cells, and plays a significant role in cancer progression. Invasive cancer cells accumulate recycling endosomes (including Rab11) at protrusions. This promotes the delivery of integrins, receptors for extracellular matrix, to regulate interactions between tumour cells and their surroundings, and coordinates actin polymerization through Rho family GTPases. The Rab11 family is particularly important in determining the aggressiveness of high-grade serous ovarian carcinoma (HGSOC). Despite its importance, the machinery that guides Rab11 trafficking and the functions of polarized trafficking are not clear in HGSOC. I aim to determine how recycling endosomes are positioned within HGSOC cells invading extracellular matrix, using BioID-based proteomics (a proximity labelling approach well established in the host lab) to identify the Rab11-associated machinery in HGSOC cells. I further aim to actively manipulate the dynamics of Rab11 positive endosomes in invading cells by developing a magnetogenetic approach to reposition endosomes in live cells, using a combination of my developed skills (including live imaging, protein engineering). Both cutting-edge methods will be applied in the most physiological and cancer relevant context to lend clinical relevance to our observations. Combining these innovative approaches will provide molecular detail and mechanistic insight to elucidate how localised endocytic trafficking controls tumour-stroma interactions in the metastatic niche and contributes to HGSOC lethality. This work will further provide targets for therapies aimed at suppressing metastasis and preventing relapse in HGSOC, a lethal form of ovarian cancer that has one of the worst survival rates (<40% 5-year survival). Moreover, this project will allow me to acquire technical skills and expertise essential for my development as an independent researcher.

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The information about "ENDOPOS" are provided by the European Opendata Portal: CORDIS opendata.

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