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ERMADA SIGNED

Illuminating Earth’s microbial diversity and origins from metagenomes with deep learning

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ERMADA project word cloud

Explore the words cloud of the ERMADA project. It provides you a very rough idea of what is the project "ERMADA" about.

effort    deeper    uncharacterized    edge    classify    analyze    microbes    galaxy    sequences    bioinformatics    serve    levels    similarity    govern    volumes    10    trained    terabytes    circulation    exceeds    genes    samples    metagenomic    12    rank    environments    twofold    conventional    sequence    cycles    elucidate    shotgun    record    metabolic    gain    enzymes    climate    dataset    latter    whereas    terrestrial       stars    structure    data    origins    environmental    staggering    nutrient    uncover    learning    painstaking    plants    diversity    microbial    capacities    models    classifying    species    outnumbers    networks    microbiome    machine    biodiversity    taxonomically    unknown    algorithms    regulating    biomass    roles    functions    play    represented    composition    reference    abstract    deep    planet    sequencing    microorganisms    prevalent    animals    neural    classified    biogeochemical    complete    network    milky    evolution    marine    genome    habitats    hundreds    emerged    cultured    cutting    pertaining    patterns    capture    footprint    employ    community       big    lineages    99    earth   

Project "ERMADA" data sheet

The following table provides information about the project.

Coordinator
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

Organization address
address: FLEMING STREET 34
city: VARI-ATHENS
postcode: 16672
website: www.fleming.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 247˙628 €
 EC max contribution 247˙628 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2023-03-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING EL (VARI-ATHENS) coordinator 247˙628.00

Map

 Project objective

The estimated number of microbes on our planet outnumbers the stars of the Milky Way galaxy and their biomass exceeds that of all plants and animals. Out of the 10^12 microbial species, only around 10^4 have been cultured, less than 10^5 species are represented by classified sequences, and a staggering estimated 99% of these microorganisms remain taxonomically unknown. Metagenomic shotgun sequencing has emerged as the most prevalent way of studying and classifying microorganisms from various habitats whereas genome analysis can be used to uncover the functions of genes, enzymes and metabolic pathways in a microbial community. This painstaking effort is crucial to understanding Earth's biodiversity, as microbes play important roles in regulating the planet’s biogeochemical cycles through processes that govern nutrient circulation in both terrestrial and marine environments. In this proposal, we will employ cutting edge bioinformatics and machine learning algorithms to analyze and elucidate Earth’s microbial diversity. We will use deep neural networks trained by large volumes of metagenomic sequences as well as big data methods to process hundreds of terabytes of data and taxonomically classify all uncharacterized metagenomic samples, by identifying their origins and habitats. Going beyond the capacities of conventional sequence similarity and comparison analyses, neural network models can capture higher level, abstract defining features and patterns in metagenomic sequences. The aim of this study is twofold: i) to gain a deeper understanding of the composition and structure of the microbiome at different rank levels and lineages and ii) to provide a complete record of the planet’s present microbial diversity footprint. The latter can serve as a reference dataset for future studies pertaining to microbiome evolution due to climate change or other long-term environmental factors.

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The information about "ERMADA" are provided by the European Opendata Portal: CORDIS opendata.

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