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BICACH TERMINATED

Novel bifunctional HAT catalysts for site-divergent C-H functionalizations mediated by photoredox catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BICACH project word cloud

Explore the words cloud of the BICACH project. It provides you a very rough idea of what is the project "BICACH" about.

alkyl    paradigm    organic    aliphatic    moiety    almost    chains    hydrogen    complexity    motif    spacer    catalytic    photoredox    position    selectively    perspectives    connected    innovative    proximity    energy    broad    hat    engage    varying    catalysis    perform    activation    ubiquitous    streamlined    shift    trigger    er    restricted    date    synthesis    light    chemical    catalysts    selectivity    feedstocks    functionalize    groups    logic    inherently    functional    active    selective    covalent    mediated    interactions    methylene    site    bonds    backbone    bicach    functionalizations    organocatalysts    molecules    direct    wish    bond    synthetically    linear    offers    tool    divergent    training    rely    event    group    transfer    bifunctional    single    breakthrough    possessing    atom    positions    nature    standard    substrate    functionalization    exhibit    molecular    plan    render    flexible    incorporating    undistinguishable    dynamic    inert    catalyst   

Project "BICACH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET REGENSBURG 

Organization address
address: UNIVERSITATSSTRASSE 31
city: REGENSBURG
postcode: 93053
website: http://www.uni-regensburg.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET REGENSBURG DE (REGENSBURG) coordinator 162˙806.00

Map

 Project objective

The direct catalytic functionalization of C-H bonds, an ubiquitous motif in organic molecules, represents a paradigm shift in the standard logic of organic synthesis. One of the major challenges to render this approach synthetically useful is to control the site-selectivity because most organic molecules exhibit several similar aliphatic C-H bonds. The functionalization of aliphatic C-H bond mediated by photoredox catalysis is a highly active field of research. To date, state-of-the-art site-selective methods in this field rely on substrate control which are inherently restricted to the functionalization of a single C-H bond within the substrate backbone. The innovative aspect of this research program is to target catalyst control to allow the site-selective functionalization of several different C-H bonds of a single substrate. Through this approach, we wish to go beyond the challenging problem of site-selectivity to enable site-divergent functionalizations. Such a breakthrough would provide a new tool for a flexible and streamlined access to molecular complexity from chemical feedstocks. To achieve our objectives, we plan to develop novel bifunctional catalysts incorporating one moiety able to engage into dynamic non-covalent interactions with the substrate and another functional group able to perform Hydrogen Atom Transfer (HAT) processes. These two functional groups are connected by an inert spacer which will position the HAT unit in proximity to a particular C-H bond of the substrate, thus controlling site-selectivity for the C-H activation event. By varying the nature of the spacer, we expect to selectively functionalize several different positions of linear alkyl chains possessing almost undistinguishable methylene C-H bonds. Overall, BICACH aims at using simple bifunctional organocatalysts and light energy to trigger highly challenging C-H functionalization processes. In addition, it offers a unique training to the ER with broad future research perspectives.

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