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EPIOBESITY TERMINATED

Unravelling the hypothalamic epigenetic code behind obesity.

Total Cost €

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EC-Contrib. €

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Partnership

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 EPIOBESITY project word cloud

Explore the words cloud of the EPIOBESITY project. It provides you a very rough idea of what is the project "EPIOBESITY" about.

training    potentially    largely    rates    candidate    models    continue    experimental    techniques    proopiomelanocortin    reversible    vivo    despite    suggests    nutrition    environmental    unavailable    treatments    cell    accessibility    signatures    hypothesis    genome    triggers    susceptibility    bioinformatics    context    balance    epigenetic    consequence    interactions    genetic    multifactorial    generation    causes    strategy    energy    line    efforts    isolate    combination    expressing    epidemics    framework    prevalent    underlying    diet    implications    western    multidisciplinary    histone    molecular    disease    turn    therapeutic    nature    titanic    pomc    biology    tag    skills    scientific    2020    pursue    fetal    transferable    first    adulthood    reliably    unfortunately    hypothalamic    host    humans    targetable    programming    followed    neurons    transfer    map    homeostasis    engineering    social    horizon    outcomes    chromatin    time    severe    dysfunction    sequencing    obesity    dysregulated    hence    innovative    safe    treatment    enigmatic    marks   

Project "EPIOBESITY" data sheet

The following table provides information about the project.

Coordinator		 CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER 

Organization address
address: CALLE ROSSELLO 149 PUERTA BJS
city: BARCELONA
postcode: 8036
website: http://www.idibaps.org/en_index.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER ES (BARCELONA) coordinator 160˙932.00

Map

 Project objective

Despite titanic social and scientific efforts, rates of obesity continue to increase in Europe. Unfortunately, safe and effective treatments are currently unavailable. Obesity is a multifactorial disease that is largely the consequence of enigmatic and complex genetic-environmental interactions. Evidence suggests that the prevalent western-diet triggers epigenetic changes that contribute to the current obesity epidemics. Hypothalamic proopiomelanocortin (POMC)-expressing neurons are crucial elements of energy balance, and its dysfunction cause severe obesity in experimental models and humans. Our hypothesis is that over nutrition causes epigenetic changes in POMC neurons that in turn lead to dysregulated energy homeostasis and obesity. The objective of this proposal is to establish for the first time a genome-wide epigenetic map of POMC neurons in the context of over nutrition during adulthood and fetal programming. To pursue this aim we will use an innovative cell-specific in vivo strategy to tag and reliably isolate POMC neurons, followed by next generation sequencing to evaluate chromatin accessibility and histone marks distribution across the genome. As a result, we will provide a novel framework for understanding the underlying epigenetic signatures related with obesity development and susceptibility. Hence, this project is in line with the Horizon 2020 Framework for improving our knowledge of the causes underlying a disease. Furthermore, the outcomes of this project may have potential therapeutic implications for the treatment of obesity since most epigenetic marks are reversible and therefore potentially targetable. The multidisciplinary nature of the project is strong, involving a combination of genetic engineering techniques, molecular biology and bioinformatics. This proposal includes the transfer of knowledge to the host institution and the training of the candidate in new techniques and transferable skills.

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The information about "EPIOBESITY" are provided by the European Opendata Portal: CORDIS opendata.

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