EPIOBESITY TERMINATED
Unravelling the hypothalamic epigenetic code behind obesity.
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0EPIOBESITY project word cloud
Explore the words cloud of the EPIOBESITY project. It provides you a very rough idea of what is the project "EPIOBESITY" about.
Project "EPIOBESITY" data sheet
The following table provides information about the project.
| Coordinator |
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Total cost | 160˙932 € |
| EC max contribution | 160˙932 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2018 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-01-01 to 2021-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER | ES (BARCELONA) | coordinator | 160˙932.00 |
Map
Project objective
Despite titanic social and scientific efforts, rates of obesity continue to increase in Europe. Unfortunately, safe and effective treatments are currently unavailable. Obesity is a multifactorial disease that is largely the consequence of enigmatic and complex genetic-environmental interactions. Evidence suggests that the prevalent western-diet triggers epigenetic changes that contribute to the current obesity epidemics. Hypothalamic proopiomelanocortin (POMC)-expressing neurons are crucial elements of energy balance, and its dysfunction cause severe obesity in experimental models and humans. Our hypothesis is that over nutrition causes epigenetic changes in POMC neurons that in turn lead to dysregulated energy homeostasis and obesity. The objective of this proposal is to establish for the first time a genome-wide epigenetic map of POMC neurons in the context of over nutrition during adulthood and fetal programming. To pursue this aim we will use an innovative cell-specific in vivo strategy to tag and reliably isolate POMC neurons, followed by next generation sequencing to evaluate chromatin accessibility and histone marks distribution across the genome. As a result, we will provide a novel framework for understanding the underlying epigenetic signatures related with obesity development and susceptibility. Hence, this project is in line with the Horizon 2020 Framework for improving our knowledge of the causes underlying a disease. Furthermore, the outcomes of this project may have potential therapeutic implications for the treatment of obesity since most epigenetic marks are reversible and therefore potentially targetable. The multidisciplinary nature of the project is strong, involving a combination of genetic engineering techniques, molecular biology and bioinformatics. This proposal includes the transfer of knowledge to the host institution and the training of the candidate in new techniques and transferable skills.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPIOBESITY" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "EPIOBESITY" are provided by the European Opendata Portal: CORDIS opendata.