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CheckBacZ SIGNED

Checkpoints in the bacterial cell cycle: role of the cytokinetic Z-ring and implications for antibiotic resistance

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CheckBacZ project word cloud

Explore the words cloud of the CheckBacZ project. It provides you a very rough idea of what is the project "CheckBacZ" about.

international    screen    strategies    fact    independent    manipulating    paving    significantly    model    corresponding    cycle    clinically    organizes    homologue    organism    super    constitutes    researcher    expertise    tolerance    signifying    driving    skills    vision    re    host    genes    ideal    synergy    establishing    ftsz    combines    threat    septum    dependent    synthesis    proteins    phenotypically    timing    determinant    aureus    techniques    myself    cutting    microfluidics    drug    sensitizing    stages    group    scientific    mutants    multiple    integration    lives    view    enforce    functional    overcome    resistances    cytokinesis    community    staphylococcal    create    healthy    precisely    resistant    impaired    ring    laboratory    treatment    valuable    varies    mutant    bacteria    serves    tubulin    professional    division    antibiotic    collaborations    resolution    staphylococcus    bears    treadmilling    cytokinetic    regulation    checkpoint    rate    edge    bacterial    alternative    controls    biology    microscopy    peptidoglycan    occurrence    combat    ongoing    generate    infections    cell    profiting    resistance    transferrable    acquire    degree   

Project "CheckBacZ" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 147˙815.00

Map

 Project objective

The occurrence of multiple-drug resistant bacteria constitutes an important threat to healthy lives, signifying the importance of alternative strategies to combat bacterial infections. This research project bears the potential to significantly contribute to overcome antibiotic resistances that occur during the treatment of bacterial infections, as it combines the studies of cell division, cell cycle regulation and antibiotic resistance in the clinically relevant model Staphylococcus aureus. Given that the tubulin homologue FtsZ is essential for cell division and serves as an antibiotic resistance determinant in this organism, the proposed research activity focuses on the cytokinetic Z-ring, more precisely its role in driving the staphylococcal cell cycle. Super-resolution microscopy will be used to determine if FtsZ treadmilling controls the rate of cytokinesis and if it organizes the peptidoglycan synthesis proteins during cell division, aiming to provide evidence for a FtsZ-dependent checkpoint in the cell cycle. Profiting from a mutant screen currently ongoing in the host laboratory, mutants impaired in the timing of septum formation will be identified to study the functional integration of corresponding genes into FtsZ-driven septum synthesis. In view of the fact that bacteria at different stages of the cell cycle are phenotypically distinct, microfluidics will be used to test if the degree of antibiotic tolerance varies during the cell cycle, which would enforce the vision for re-sensitizing resistant bacteria by manipulating their cell cycle. The strong expertise and the availability of cutting-edge techniques in the host group together with my professional experience will generate an ideal synergy within this work programme. I will generate valuable scientific knowledge, acquire transferrable skills and create new collaborations in the international bacterial cell biology community, thus paving the way for establishing myself as an independent researcher.

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The information about "CHECKBACZ" are provided by the European Opendata Portal: CORDIS opendata.

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