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CheckBacZ SIGNED

Checkpoints in the bacterial cell cycle: role of the cytokinetic Z-ring and implications for antibiotic resistance

Total Cost €

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EC-Contrib. €

0

Partnership

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 CheckBacZ project word cloud

Explore the words cloud of the CheckBacZ project. It provides you a very rough idea of what is the project "CheckBacZ" about.

synthesis    resolution    synergy    functional    transferrable    impaired    tolerance    constitutes    overcome    paving    establishing    varies    tubulin    researcher    super    edge    threat    healthy    treatment    serves    ideal    occurrence    resistant    lives    dependent    scientific    treadmilling    mutant    precisely    combines    homologue    multiple    infections    bears    integration    degree    model    staphylococcus    microfluidics    resistance    international    biology    host    myself    re    peptidoglycan    alternative    septum    techniques    create    group    valuable    genes    ring    view    professional    timing    checkpoint    cutting    driving    skills    ftsz    microscopy    expertise    phenotypically    organism    manipulating    cell    strategies    laboratory    collaborations    organizes    signifying    aureus    vision    corresponding    bacterial    staphylococcal    community    antibiotic    division    stages    independent    enforce    mutants    clinically    controls    determinant    regulation    bacteria    fact    cytokinesis    cytokinetic    drug    significantly    cycle    acquire    ongoing    screen    profiting    combat    resistances    rate    proteins    generate    sensitizing   

Project "CheckBacZ" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 147˙815.00

Map

 Project objective

The occurrence of multiple-drug resistant bacteria constitutes an important threat to healthy lives, signifying the importance of alternative strategies to combat bacterial infections. This research project bears the potential to significantly contribute to overcome antibiotic resistances that occur during the treatment of bacterial infections, as it combines the studies of cell division, cell cycle regulation and antibiotic resistance in the clinically relevant model Staphylococcus aureus. Given that the tubulin homologue FtsZ is essential for cell division and serves as an antibiotic resistance determinant in this organism, the proposed research activity focuses on the cytokinetic Z-ring, more precisely its role in driving the staphylococcal cell cycle. Super-resolution microscopy will be used to determine if FtsZ treadmilling controls the rate of cytokinesis and if it organizes the peptidoglycan synthesis proteins during cell division, aiming to provide evidence for a FtsZ-dependent checkpoint in the cell cycle. Profiting from a mutant screen currently ongoing in the host laboratory, mutants impaired in the timing of septum formation will be identified to study the functional integration of corresponding genes into FtsZ-driven septum synthesis. In view of the fact that bacteria at different stages of the cell cycle are phenotypically distinct, microfluidics will be used to test if the degree of antibiotic tolerance varies during the cell cycle, which would enforce the vision for re-sensitizing resistant bacteria by manipulating their cell cycle. The strong expertise and the availability of cutting-edge techniques in the host group together with my professional experience will generate an ideal synergy within this work programme. I will generate valuable scientific knowledge, acquire transferrable skills and create new collaborations in the international bacterial cell biology community, thus paving the way for establishing myself as an independent researcher.

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The information about "CHECKBACZ" are provided by the European Opendata Portal: CORDIS opendata.

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