Opendata, web and dolomites

CheckBacZ SIGNED

Checkpoints in the bacterial cell cycle: role of the cytokinetic Z-ring and implications for antibiotic resistance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CheckBacZ project word cloud

Explore the words cloud of the CheckBacZ project. It provides you a very rough idea of what is the project "CheckBacZ" about.

healthy    ideal    vision    septum    scientific    stages    international    varies    paving    generate    antibiotic    tolerance    skills    controls    expertise    degree    integration    valuable    division    cutting    threat    group    strategies    resistance    determinant    functional    homologue    synthesis    cell    resistant    cycle    bacterial    multiple    dependent    clinically    timing    staphylococcus    microscopy    combines    alternative    regulation    create    combat    cytokinesis    biology    acquire    corresponding    myself    proteins    serves    precisely    community    rate    host    tubulin    manipulating    ftsz    aureus    occurrence    independent    researcher    checkpoint    infections    treadmilling    signifying    edge    enforce    screen    resistances    organizes    resolution    mutant    drug    genes    transferrable    collaborations    ring    significantly    model    treatment    peptidoglycan    fact    profiting    bears    bacteria    staphylococcal    lives    driving    sensitizing    overcome    organism    constitutes    microfluidics    mutants    phenotypically    ongoing    laboratory    view    establishing    cytokinetic    impaired    super    professional    techniques    synergy    re   

Project "CheckBacZ" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 147˙815.00

Map

 Project objective

The occurrence of multiple-drug resistant bacteria constitutes an important threat to healthy lives, signifying the importance of alternative strategies to combat bacterial infections. This research project bears the potential to significantly contribute to overcome antibiotic resistances that occur during the treatment of bacterial infections, as it combines the studies of cell division, cell cycle regulation and antibiotic resistance in the clinically relevant model Staphylococcus aureus. Given that the tubulin homologue FtsZ is essential for cell division and serves as an antibiotic resistance determinant in this organism, the proposed research activity focuses on the cytokinetic Z-ring, more precisely its role in driving the staphylococcal cell cycle. Super-resolution microscopy will be used to determine if FtsZ treadmilling controls the rate of cytokinesis and if it organizes the peptidoglycan synthesis proteins during cell division, aiming to provide evidence for a FtsZ-dependent checkpoint in the cell cycle. Profiting from a mutant screen currently ongoing in the host laboratory, mutants impaired in the timing of septum formation will be identified to study the functional integration of corresponding genes into FtsZ-driven septum synthesis. In view of the fact that bacteria at different stages of the cell cycle are phenotypically distinct, microfluidics will be used to test if the degree of antibiotic tolerance varies during the cell cycle, which would enforce the vision for re-sensitizing resistant bacteria by manipulating their cell cycle. The strong expertise and the availability of cutting-edge techniques in the host group together with my professional experience will generate an ideal synergy within this work programme. I will generate valuable scientific knowledge, acquire transferrable skills and create new collaborations in the international bacterial cell biology community, thus paving the way for establishing myself as an independent researcher.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CHECKBACZ" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CHECKBACZ" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

STUDYES (2019)

Structure and Ultrafast Dynamics in Deep Eutectic Solvents

Read More  

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More