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CheckBacZ SIGNED

Checkpoints in the bacterial cell cycle: role of the cytokinetic Z-ring and implications for antibiotic resistance

Total Cost €

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EC-Contrib. €

0

Partnership

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 CheckBacZ project word cloud

Explore the words cloud of the CheckBacZ project. It provides you a very rough idea of what is the project "CheckBacZ" about.

bacteria    screen    treadmilling    resistant    functional    resolution    threat    host    precisely    regulation    corresponding    generate    sensitizing    occurrence    myself    tolerance    resistances    skills    tubulin    controls    proteins    alternative    organizes    phenotypically    expertise    ring    establishing    community    combat    ongoing    constitutes    manipulating    super    clinically    genes    stages    synergy    model    view    professional    degree    organism    cell    serves    re    paving    antibiotic    group    resistance    mutants    international    septum    infections    cycle    researcher    drug    signifying    treatment    synthesis    cytokinesis    impaired    bacterial    techniques    profiting    multiple    peptidoglycan    biology    ideal    bears    valuable    cutting    enforce    independent    strategies    fact    overcome    driving    create    varies    checkpoint    staphylococcal    determinant    mutant    division    lives    acquire    vision    staphylococcus    cytokinetic    healthy    scientific    dependent    rate    transferrable    edge    aureus    significantly    microfluidics    collaborations    combines    laboratory    homologue    integration    microscopy    timing    ftsz   

Project "CheckBacZ" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 147˙815.00

Map

 Project objective

The occurrence of multiple-drug resistant bacteria constitutes an important threat to healthy lives, signifying the importance of alternative strategies to combat bacterial infections. This research project bears the potential to significantly contribute to overcome antibiotic resistances that occur during the treatment of bacterial infections, as it combines the studies of cell division, cell cycle regulation and antibiotic resistance in the clinically relevant model Staphylococcus aureus. Given that the tubulin homologue FtsZ is essential for cell division and serves as an antibiotic resistance determinant in this organism, the proposed research activity focuses on the cytokinetic Z-ring, more precisely its role in driving the staphylococcal cell cycle. Super-resolution microscopy will be used to determine if FtsZ treadmilling controls the rate of cytokinesis and if it organizes the peptidoglycan synthesis proteins during cell division, aiming to provide evidence for a FtsZ-dependent checkpoint in the cell cycle. Profiting from a mutant screen currently ongoing in the host laboratory, mutants impaired in the timing of septum formation will be identified to study the functional integration of corresponding genes into FtsZ-driven septum synthesis. In view of the fact that bacteria at different stages of the cell cycle are phenotypically distinct, microfluidics will be used to test if the degree of antibiotic tolerance varies during the cell cycle, which would enforce the vision for re-sensitizing resistant bacteria by manipulating their cell cycle. The strong expertise and the availability of cutting-edge techniques in the host group together with my professional experience will generate an ideal synergy within this work programme. I will generate valuable scientific knowledge, acquire transferrable skills and create new collaborations in the international bacterial cell biology community, thus paving the way for establishing myself as an independent researcher.

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The information about "CHECKBACZ" are provided by the European Opendata Portal: CORDIS opendata.

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