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CheckBacZ SIGNED

Checkpoints in the bacterial cell cycle: role of the cytokinetic Z-ring and implications for antibiotic resistance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CheckBacZ project word cloud

Explore the words cloud of the CheckBacZ project. It provides you a very rough idea of what is the project "CheckBacZ" about.

generate    drug    combat    ideal    transferrable    occurrence    myself    vision    microfluidics    microscopy    expertise    valuable    serves    resolution    tolerance    resistances    ring    combines    tubulin    division    peptidoglycan    checkpoint    resistance    professional    view    community    impaired    cutting    mutants    varies    independent    re    profiting    biology    mutant    ongoing    clinically    resistant    cytokinesis    multiple    enforce    timing    laboratory    constitutes    scientific    aureus    dependent    overcome    bacterial    synergy    edge    paving    organism    techniques    collaborations    precisely    septum    staphylococcus    treadmilling    strategies    driving    proteins    functional    cytokinetic    treatment    determinant    synthesis    bears    homologue    signifying    model    stages    international    manipulating    significantly    regulation    screen    rate    host    cell    organizes    acquire    group    researcher    healthy    sensitizing    degree    super    create    lives    fact    controls    antibiotic    staphylococcal    infections    skills    cycle    bacteria    genes    alternative    integration    threat    establishing    ftsz    phenotypically    corresponding   

Project "CheckBacZ" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 147˙815.00

Map

 Project objective

The occurrence of multiple-drug resistant bacteria constitutes an important threat to healthy lives, signifying the importance of alternative strategies to combat bacterial infections. This research project bears the potential to significantly contribute to overcome antibiotic resistances that occur during the treatment of bacterial infections, as it combines the studies of cell division, cell cycle regulation and antibiotic resistance in the clinically relevant model Staphylococcus aureus. Given that the tubulin homologue FtsZ is essential for cell division and serves as an antibiotic resistance determinant in this organism, the proposed research activity focuses on the cytokinetic Z-ring, more precisely its role in driving the staphylococcal cell cycle. Super-resolution microscopy will be used to determine if FtsZ treadmilling controls the rate of cytokinesis and if it organizes the peptidoglycan synthesis proteins during cell division, aiming to provide evidence for a FtsZ-dependent checkpoint in the cell cycle. Profiting from a mutant screen currently ongoing in the host laboratory, mutants impaired in the timing of septum formation will be identified to study the functional integration of corresponding genes into FtsZ-driven septum synthesis. In view of the fact that bacteria at different stages of the cell cycle are phenotypically distinct, microfluidics will be used to test if the degree of antibiotic tolerance varies during the cell cycle, which would enforce the vision for re-sensitizing resistant bacteria by manipulating their cell cycle. The strong expertise and the availability of cutting-edge techniques in the host group together with my professional experience will generate an ideal synergy within this work programme. I will generate valuable scientific knowledge, acquire transferrable skills and create new collaborations in the international bacterial cell biology community, thus paving the way for establishing myself as an independent researcher.

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The information about "CHECKBACZ" are provided by the European Opendata Portal: CORDIS opendata.

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