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NeuroStemX SIGNED

In vitro model of Fragile X Syndrome using naïve iPSCs

Total Cost €

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EC-Contrib. €

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Partnership

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 NeuroStemX project word cloud

Explore the words cloud of the NeuroStemX project. It provides you a very rough idea of what is the project "NeuroStemX" about.

disorder    skills    methylation    therapies    function    spectrum    mental    neurostemx    er    conjunction    pscs    maturity    advantage    microtechnologies    syndrome    gap    independence    defects    outstanding    repeat    enlarge    models    showing    pathogenesis    timing    brain    priorities    vitro    innovative    protein    gene    university    neural    disability    patients    variety    retardation    ipscs    filling    model    trinucleotide    neurological    autism    competences    profile    dysfunction    disease    scientific    fragile    molecular    genome    strengthen    hope    vivo    optimized    training    fxs    corresponding    mastered    multidisciplinary    contradictory    disorders    give    modeling    personalized    epigenetic    leads    researcher    na    fmr1    mechanism    transferable    expansion    data    intellectual    monogenetic    iuml    opportunity    professional    generation    promoter    technique    neuronal    fmrp    establishing    actively    partial    unknown    silencing    padova    absence    frequently    opened    ve    invests    neurons    unipd    unmethylated   

Project "NeuroStemX" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 183˙473.00

Map

 Project objective

Neurological and mental disorders are top priorities for the European Commission, which actively invests in research aimed at better understanding brain function and dysfunction, and at finding new therapies for brain disorders. Fragile X syndrome (FXS) is the major monogenetic cause for intellectual disability and is frequently associated with autism spectrum disorder. The trinucleotide repeat expansion, methylation and epigenetic silencing of fragile mental retardation 1 (FMR1) gene promoter leads to the loss of the corresponding protein. However, the molecular mechanism and the timing leading to FMR1 silencing are still unknown due to the absence of reliable in vivo and in vitro models. The recent development of naïve PSCs showing a broader unmethylated genome (including in FMR1) opened a new hope for disease modeling of FXS, but data are still partial and contradictory. The NeuroStemX project aims at filling this gap taking advantage of an optimized technique for the generation of naïve iPSCs developed at the University of Padova (UniPd) and generation of FXS neurons with various approaches mastered by the Experienced Researcher (ER) in conjunction with the microtechnologies developed by UniPd. In particular, we aim at 1) identifying the timing of FMRP silencing during neural development using naïve iPSCs and 2) establishing a reliable in vitro system to model neuronal defects observed in FXS patients. In this project, we are addressing some of the most crucial problems related with FXS pathogenesis and modeling using a variety of innovative approaches. This will give the ER an outstanding training-through-research opportunity by means of a personalized multidisciplinary project, in which the ER will enlarge her scientific competences and strengthen her professional profile. The training includes both scientific and transferable skills, aimed at the reinforcement of the ER professional maturity and independence.

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The information about "NEUROSTEMX" are provided by the European Opendata Portal: CORDIS opendata.

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