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FLUORODRUGS

Smart Theranostic Agents for the Tumour Microenvironment

Total Cost €

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EC-Contrib. €

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Partnership

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Project "FLUORODRUGS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.dynafluors.co.uk
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 195˙454.00

Map

 Project objective

FLUORODRUGS is a highly interdisciplinary project encompassing the design, synthesis and biological validation of novel smart chemical agents for highly sensitive diagnosis and specific treatment of cancer. I will prepare novel drug-fluorophores conjugates by combining macrophage-specific fluorophores with cytotoxic drugs using smart cleavable linkers. The activation of these smart agents in the tumour microenvironment will allow to not only to visualise in real-time but also to selectively ablate tumour-associated macrophages, which are essential for cancer progression. Further derivatization of the agents with specific ligands (i.e. chemokine CCL2) will yield probes for specific subpopulations of macrophages (i.e. CCR2 macrophages) that are critical in tumour metastasis. This strategy will minimise two of the major limitations of conventional cancer therapies: 1) drug resistance from cancer cells, and 2) toxic side effects derived from low cell specificity. Notably, the visualisation of immune cells in the tumour microenvironment will allow to monitor cancer progression in real-time and to run profiling studies to discover new biomarkers for cancer therapy. Initial in vitro studies to confirm the activity and selectivity of FLUORODRUGS will be performed in bone marrow-derived macrophages. Further, relevant mouse cancer models will be used to validate the theranostic agents in vivo. FLUORODRUGS will involve multidisciplinary training in biology, spectroscopy, pharmacology and imaging, and will render a unique generation of smart chemical tools to enhance diagnosis and treatment of cancer. This project will open a whole range of opportunities for my future career development in cancer biology and medicinal chemistry.

 Publications

year authors and title journal last update
List of publications.
2018 Richard J. Mellanby, Jamie I. Scott, Iris Mair, Antonio Fernandez, Louise Saul, Jochen Arlt, Monica Moral, Marc Vendrell
Tricarbocyanine N -triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo
published pages: 7261-7270, ISSN: 2041-6520, DOI: 10.1039/c8sc00900g
Chemical Science 9/36 2019-07-30
2017 Antonio Fernandez, Matthieu Vermeren, Duncan Humphries, Ramon Subiros-Funosas, Nicole Barth, Lara Campana, Alison MacKinnon, Yi Feng, Marc Vendrell
Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates
published pages: 995-1005, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00262
ACS Central Science 3/9 2019-07-30
2018 Antonio Fernandez, Marc Vendrell
Fluorophore–Drug Conjugates To Unravel the Mechanisms of Action of Therapeutic Assets
published pages: 175-176, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.7b00889
Biochemistry 57/2 2019-07-30
2019 Sam Benson, Antonio Fernandez, Nicole D Barth, Fabio de Moliner, Mathew H Horrocks, Simon Herrington, Jose Luis Abad, Antonio Delgado, Lisa Kelly, Zi Chang, Yi Feng, Miyako Nishiura, Yuichiro Hori, Kazuya Kikuchi, Marc Vendrell
SCOTfluors: Small, Conjugatable, Orthogonal and Tunable Fluorophores for in vivo Imaging of Cell Metabolism
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201900465
Angewandte Chemie 2019-07-30

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