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MGLycan SIGNED

Targeting hMGL-GalNAc interactions to reverse immune suppression in cancer

Total Cost €

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EC-Contrib. €

0

Partnership

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 MGLycan project word cloud

Explore the words cloud of the MGLycan project. It provides you a very rough idea of what is the project "MGLycan" about.

immunosuppression    accompanied    diverse    binding    antigen    ser    interaction    secretion    fact    alpha    playing    ligands    immunotherapy    macrophage    signaling    dendritic    overlooked    moieties    receptors    clear    tolerogenic    galnac    upregulated    glycosylation    toward    cell    facilitated    cells    glycan    macrophages    vaccines    immune    efficacy    recognizes    interacts    aberrant    human    tn    tacas    limits    serve    induction    carbohydrate    terminal    synthesis    immature    mostly    apoptosis    affinity    proliferation    galactose    mimetics    surface    perceives    appearance    suppression    selective    thr    cancer    tumor    despite    clr    truncated    receptor    mechanisms    escape    antigens    hallmarks    multivalent    mgl    poorly    induce    lectin    mediated    clrs    cytokine    ing    effector    hmgl    mediate    prime    interactions    immunosuppressive    inhibitors    carbohydrates    evasion    glycans    alters    strategies    dcs    reverse   

Project "MGLycan" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 172˙932.00

Map

 Project objective

The appearance of aberrant glycans on the tumor cell surface is one of the emerging hallmarks of cancer. Tumor growth is accompanied by tumor evasion of the immune system which limits the efficacy of cancer vaccines. However, and despite the fact that aberrant tumor glycosylation alters how the immune system perceives the tumor and, can also induce immunosuppressive signaling through glycan-binding receptors, the role of tumor glycosylation in immune evasion has mostly been overlooked. It is clear that new strategies to avoid the immune escape mechanisms generated by tumor cells are required. The interaction between the immune system and Tumor-Associated Carbohydrates Antigens (TACAs) is facilitated by a diverse set of carbohydrate-binding receptors, as the C-type lectin receptors (CLRs) which mediate specific interactions with TACAs controlling many features of the immune response. The immune escape mechanisms generated by truncated O-glycans, such as Tn antigen (αGalNAc-Ser/Thr) are still poorly understood. Human macrophage galactose-type lectin (hMGL) is a CLR that recognizes terminal GalNAc moieties, and is, therefore, a prime receptor for the aberrant O-glycans in cancer. MGL is upregulated in tolerogenic and immature dendritic cells (DCs) and macrophages playing an important role in immunosuppression. It interacts with effector T-cells, resulting in reduced proliferation, cytokine secretion and induction of T-cell apoptosis. In this project, we propose the design and synthesis of multivalent MGL ligands mimetics with an improved affinity toward this receptor, that will serve as selective inhibitors to reverse GalNAc-mediated immune suppression for cancer immunotherapy.

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The information about "MGLYCAN" are provided by the European Opendata Portal: CORDIS opendata.

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