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MGLycan SIGNED

Targeting hMGL-GalNAc interactions to reverse immune suppression in cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MGLycan project word cloud

Explore the words cloud of the MGLycan project. It provides you a very rough idea of what is the project "MGLycan" about.

mostly    effector    signaling    galactose    immune    lectin    truncated    fact    strategies    accompanied    glycans    interacts    secretion    facilitated    cell    immunosuppression    prime    dendritic    tn    mediate    multivalent    apoptosis    limits    mediated    toward    macrophage    selective    synthesis    aberrant    alpha    receptors    suppression    diverse    clrs    cells    glycan    immunotherapy    ser    ing    tacas    cytokine    ligands    hallmarks    evasion    reverse    tolerogenic    moieties    human    clear    carbohydrates    interactions    vaccines    induction    immature    perceives    appearance    surface    immunosuppressive    escape    receptor    recognizes    antigens    upregulated    playing    poorly    proliferation    hmgl    tumor    serve    despite    binding    alters    macrophages    inhibitors    mgl    terminal    carbohydrate    galnac    efficacy    glycosylation    clr    thr    affinity    dcs    antigen    mimetics    interaction    cancer    mechanisms    induce    overlooked   

Project "MGLycan" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 172˙932.00

Map

 Project objective

The appearance of aberrant glycans on the tumor cell surface is one of the emerging hallmarks of cancer. Tumor growth is accompanied by tumor evasion of the immune system which limits the efficacy of cancer vaccines. However, and despite the fact that aberrant tumor glycosylation alters how the immune system perceives the tumor and, can also induce immunosuppressive signaling through glycan-binding receptors, the role of tumor glycosylation in immune evasion has mostly been overlooked. It is clear that new strategies to avoid the immune escape mechanisms generated by tumor cells are required. The interaction between the immune system and Tumor-Associated Carbohydrates Antigens (TACAs) is facilitated by a diverse set of carbohydrate-binding receptors, as the C-type lectin receptors (CLRs) which mediate specific interactions with TACAs controlling many features of the immune response. The immune escape mechanisms generated by truncated O-glycans, such as Tn antigen (αGalNAc-Ser/Thr) are still poorly understood. Human macrophage galactose-type lectin (hMGL) is a CLR that recognizes terminal GalNAc moieties, and is, therefore, a prime receptor for the aberrant O-glycans in cancer. MGL is upregulated in tolerogenic and immature dendritic cells (DCs) and macrophages playing an important role in immunosuppression. It interacts with effector T-cells, resulting in reduced proliferation, cytokine secretion and induction of T-cell apoptosis. In this project, we propose the design and synthesis of multivalent MGL ligands mimetics with an improved affinity toward this receptor, that will serve as selective inhibitors to reverse GalNAc-mediated immune suppression for cancer immunotherapy.

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