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MechTransition SIGNED

Regulatory mechanisms controlling a new mechanical Epithelial to Mesenchymal Transition in zebrafish

Total Cost €

0

EC-Contrib. €

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Partnership

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Project "MechTransition" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 224˙933.00

Map

 Project objective

While cancer biologists have long assumed that developmental Epithelial to Mesenchymal Transitions (EMT) transcriptional programs also control cancer metastasis, our lab has recently found that cancer EMT instead uses a mechanical-based two-step process. Typically, epithelial cells fated to die get extruded apically into the lumen. However, oncogenic mutations that drive metastatic cancers hijack this process, causing cells to either form masses or to extrude basally back into the tissue at separate sites. Basal extrusion causes transformed cells to not only invade but also to lose their entire apical membranes, including their E-cadherins, which are critical to epithelial identity. Later, invading cells migrate using a stable-bleb type motility typical of cells in confined spaces and then transdifferentiate into a variety of different cell types. While our lab has established that basal extrusion causes invasion and loss of epithelial identity, it is unclear what later causes cells to become mesenchymal. Using the transparent zebrafish embryo, I will investigate the mechanisms that promote the second step of EMT by answering the following questions: 1) Does mechanical stress following basal extrusion cause trans-differentiation of invading cells? 2) What programs promote EMT of transformed cells? 3) What environments allow invading cells to colonise specific tissues? Our new EMT model represents a paradigm shift in our understanding of how tumour cells initiate metastasis, survive in different environments, and become distinct cell types. Thus, addressing these aims could impact our ability to finally treat metastatic disease.

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The information about "MECHTRANSITION" are provided by the European Opendata Portal: CORDIS opendata.

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