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PiQiMosqBite SIGNED

Understanding the roles of pathogen infection and sensory cue integration in mosquito blood-feeding behavior

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PiQiMosqBite project word cloud

Explore the words cloud of the PiQiMosqBite project. It provides you a very rough idea of what is the project "PiQiMosqBite" about.

malaria    assay    underlying    mutant    throughput    quantitatively    surface    pathogen    cues    vasculature    effect    microfabricaton    despite    interactions    ill    falciparum    transparent    transmission    mosquito    overcome    combining    transmitted    simultaneously    insights    pathogens    deficient    lack    integration    dissect    plasmodium    poorly    innovative    counterparts    artificial    leveraging    serve    expectoration    gambiae    limitations    combat    create    skills    saliva    unravel    risk    half    blood    virus    dynamics    compare    borne    vision    cue    deep    behavior    infection    chemical    skin    infections    trajectory    infected    diseases    vector    anopheles    physical    vectors    host    labs    mimics    gaps    engineered    tools    human    biting    expertise    quantitative    below    aegypti    imaging    mimic    neurobiology    embed    behavioral    elucidating    sensory    biophysics    aedes    world    characterization    population    mosquitoes    computer    feeding    valuable    dengue   

Project "PiQiMosqBite" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 196˙707.00

Map

 Project objective

Mosquitoes serve as vectors for diseases including dengue and malaria, for which half the world's population is at risk. Mosquito-borne pathogens are transmitted during blood feeding, yet despite its crucial role in pathogen transmission, blood feeding behavior remains ill understood. The sensory integration of physical and chemical cues on the skin and below its surface, and the effect of pathogen infection on blood feeding are poorly characterized. These knowledge gaps are due to a lack of tools to quantitatively study blood feeding behavior. To overcome these limitations, I propose an innovative approach to study blood feeding by leveraging quantitative imaging, computer vision, and an engineered human skin mimic to create a high-throughput behavioral assay. Imaging mosquitoes feeding on a transparent skin mimic will enable the detailed characterization of the behavioral trajectory leading to blood feeding while simultaneously allowing the analysis of biting dynamics by imaging the expectoration of saliva. To unravel the behavioral effects of pathogen infection, I will compare blood feeding by non-infected Aedes aegypti (the main dengue vector) and Anopheles gambiae (an important malaria vector) with their dengue virus and Plasmodium falciparum infected counterparts. Next, I will use microfabricaton to embed artificial vasculature in the skin mimic to dissect the sensory cue integration underlying blood feeding. I will characterize the biting dynamics of mutant Aedes aegypti deficient in various sensory pathways feeding on skin mimics that present a defined set of cues. By combining my skills in biophysics with the host labs expertise in mosquito-pathogen interactions, this project will provide a deep understanding of the neurobiology underlying blood feeding by mosquitoes, and the effect that pathogen infections may have on this behavior. Elucidating the transmission of mosquito-borne pathogens will provide valuable insights to combat mosquito-borne diseases.

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The information about "PIQIMOSQBITE" are provided by the European Opendata Portal: CORDIS opendata.

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