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PiQiMosqBite SIGNED

Understanding the roles of pathogen infection and sensory cue integration in mosquito blood-feeding behavior

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PiQiMosqBite project word cloud

Explore the words cloud of the PiQiMosqBite project. It provides you a very rough idea of what is the project "PiQiMosqBite" about.

virus    plasmodium    counterparts    neurobiology    mosquitoes    mutant    serve    pathogens    limitations    elucidating    simultaneously    quantitatively    transmission    skills    artificial    anopheles    half    diseases    microfabricaton    host    world    ill    malaria    effect    integration    create    behavioral    mosquito    leveraging    vectors    deficient    sensory    expertise    labs    physical    infection    vector    dynamics    overcome    biophysics    aegypti    gambiae    poorly    unravel    engineered    transmitted    gaps    interactions    assay    chemical    skin    expectoration    falciparum    compare    tools    feeding    blood    dengue    insights    deep    combat    below    borne    valuable    infections    saliva    cue    trajectory    innovative    underlying    infected    risk    vasculature    imaging    behavior    dissect    mimic    cues    quantitative    despite    aedes    biting    surface    human    lack    mimics    characterization    transparent    pathogen    computer    vision    embed    population    throughput    combining   

Project "PiQiMosqBite" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 196˙707.00

Map

 Project objective

Mosquitoes serve as vectors for diseases including dengue and malaria, for which half the world's population is at risk. Mosquito-borne pathogens are transmitted during blood feeding, yet despite its crucial role in pathogen transmission, blood feeding behavior remains ill understood. The sensory integration of physical and chemical cues on the skin and below its surface, and the effect of pathogen infection on blood feeding are poorly characterized. These knowledge gaps are due to a lack of tools to quantitatively study blood feeding behavior. To overcome these limitations, I propose an innovative approach to study blood feeding by leveraging quantitative imaging, computer vision, and an engineered human skin mimic to create a high-throughput behavioral assay. Imaging mosquitoes feeding on a transparent skin mimic will enable the detailed characterization of the behavioral trajectory leading to blood feeding while simultaneously allowing the analysis of biting dynamics by imaging the expectoration of saliva. To unravel the behavioral effects of pathogen infection, I will compare blood feeding by non-infected Aedes aegypti (the main dengue vector) and Anopheles gambiae (an important malaria vector) with their dengue virus and Plasmodium falciparum infected counterparts. Next, I will use microfabricaton to embed artificial vasculature in the skin mimic to dissect the sensory cue integration underlying blood feeding. I will characterize the biting dynamics of mutant Aedes aegypti deficient in various sensory pathways feeding on skin mimics that present a defined set of cues. By combining my skills in biophysics with the host labs expertise in mosquito-pathogen interactions, this project will provide a deep understanding of the neurobiology underlying blood feeding by mosquitoes, and the effect that pathogen infections may have on this behavior. Elucidating the transmission of mosquito-borne pathogens will provide valuable insights to combat mosquito-borne diseases.

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The information about "PIQIMOSQBITE" are provided by the European Opendata Portal: CORDIS opendata.

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