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AstroCOMET SIGNED

Astrocyte-neuron COmmunication in METabolism and obesity.

Total Cost €

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EC-Contrib. €

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Partnership

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 AstroCOMET project word cloud

Explore the words cloud of the AstroCOMET project. It provides you a very rough idea of what is the project "AstroCOMET" about.

acquisition    society    contributes    2020    maintaining    body    brain    glucose    matthias    pathogenesis    al    astrocytes    tsch    interfere    metabolic    last    energy    prevalent    creativity    mechanism    suppression    reveal    models    led    privileged    homeostasis    skill    metabolism    group    hypothalamic    decades    hypercaloric    communication    molecular    intake    generate    representing    competence    contribution    astrocyte    cell    suggest    balance    receptors    hypothesis    transgenic    diabetes    activated    gliotransmitters    horizon    diet    glial    progression    irs    normal    disrupts    prof    exclusively    diseases    et    regulate    training    lack    dreadd    interplay    insulin    ouml    vesicles    dnsnare    data    neurons    individual    garcia    designer    leads    2016    thereof    environment    weight    obesity    food    impairment    cells    mouse    until    explains    reported    supportive    examine    host    release    caceres    underpinnings    drugs    neuron    ibot    cns    paradigm   

Project "AstroCOMET" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 174˙806.00

Map

 Project objective

Obesity and type 2 diabetes have been increasing during the last decades, becoming highly prevalent diseases in our society. Until very recently, astrocytes and other glial cells have been traditionally known as supportive cells to neurons, but the host research group led by Prof. Matthias Tschöp has recently reported that insulin receptors (IRs) in astrocytes regulate glucose delivery into the brain and lack thereof leads to a reduced response of glucose-induced suppression of food intake (Garcia-Caceres et al., Cell 2016). These data, together with previous findings, suggest a new paradigm in which astrocytes interplay with neurons in the CNS control of metabolism, body weight, and energy balance. However, the molecular underpinnings remain to be investigated. My main objective is to test the hypothesis that astrocyte-neuron communication is required for maintaining a normal energy homeostasis, and its impairment contributes to the pathogenesis of obesity. To achieve this, I will use Designer Receptors Exclusively Activated by Designer Drugs (DREADD) technology to examine whether astrocyte activity is required for maintaining a normal energy homeostasis. I will generate two transgenic mouse models (dnSNARE mouse and iBot mouse) to specifically interfere with the release of gliotransmitters in order to test whether astrocytes release vesicles to regulate the activity of hypothalamic neurons in the control of energy metabolism. Finally, I will investigate whether hypercaloric diet disrupts astrocyte-neuron communication, thus contributing to obesity progression. This project has the potential to reveal new mechanism(s) of metabolic homeostasis and how its impairment explains the development of obesity. Moreover, this proposal will enhance my individual competence in terms of skill acquisition and creativity through an advanced training in a privileged host environment; representing all together a significant contribution to the Horizon 2020 Work Programme.

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The information about "ASTROCOMET" are provided by the European Opendata Portal: CORDIS opendata.

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