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AstroCOMET SIGNED

Astrocyte-neuron COmmunication in METabolism and obesity.

Total Cost €

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EC-Contrib. €

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Partnership

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 AstroCOMET project word cloud

Explore the words cloud of the AstroCOMET project. It provides you a very rough idea of what is the project "AstroCOMET" about.

maintaining    progression    data    impairment    hypothesis    weight    designer    privileged    2020    contribution    disrupts    generate    prof    last    ibot    exclusively    decades    activated    group    interplay    dnsnare    dreadd    host    reported    leads    vesicles    garcia    led    gliotransmitters    interfere    paradigm    obesity    matthias    caceres    suggest    acquisition    normal    regulate    insulin    glucose    irs    transgenic    diseases    receptors    balance    release    mechanism    representing    metabolic    food    neurons    hypothalamic    examine    reveal    horizon    suppression    diet    ouml    cell    mouse    astrocytes    2016    underpinnings    society    lack    communication    energy    supportive    body    metabolism    thereof    tsch    explains    glial    al    models    intake    prevalent    skill    contributes    pathogenesis    creativity    competence    et    astrocyte    environment    homeostasis    individual    neuron    drugs    brain    hypercaloric    until    cns    training    diabetes    molecular    cells   

Project "AstroCOMET" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 174˙806.00

Map

 Project objective

Obesity and type 2 diabetes have been increasing during the last decades, becoming highly prevalent diseases in our society. Until very recently, astrocytes and other glial cells have been traditionally known as supportive cells to neurons, but the host research group led by Prof. Matthias Tschöp has recently reported that insulin receptors (IRs) in astrocytes regulate glucose delivery into the brain and lack thereof leads to a reduced response of glucose-induced suppression of food intake (Garcia-Caceres et al., Cell 2016). These data, together with previous findings, suggest a new paradigm in which astrocytes interplay with neurons in the CNS control of metabolism, body weight, and energy balance. However, the molecular underpinnings remain to be investigated. My main objective is to test the hypothesis that astrocyte-neuron communication is required for maintaining a normal energy homeostasis, and its impairment contributes to the pathogenesis of obesity. To achieve this, I will use Designer Receptors Exclusively Activated by Designer Drugs (DREADD) technology to examine whether astrocyte activity is required for maintaining a normal energy homeostasis. I will generate two transgenic mouse models (dnSNARE mouse and iBot mouse) to specifically interfere with the release of gliotransmitters in order to test whether astrocytes release vesicles to regulate the activity of hypothalamic neurons in the control of energy metabolism. Finally, I will investigate whether hypercaloric diet disrupts astrocyte-neuron communication, thus contributing to obesity progression. This project has the potential to reveal new mechanism(s) of metabolic homeostasis and how its impairment explains the development of obesity. Moreover, this proposal will enhance my individual competence in terms of skill acquisition and creativity through an advanced training in a privileged host environment; representing all together a significant contribution to the Horizon 2020 Work Programme.

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The information about "ASTROCOMET" are provided by the European Opendata Portal: CORDIS opendata.

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