EU H2020 Project "FOOD-PPP-NAFLD (Discovery and characterization of food bioactive compounds modulating the..)": description, partecipants, costs and EC-fundings

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Food-PPP-NAFLD project word cloud

Explore the words cloud of the Food-PPP-NAFLD project. It provides you a very rough idea of what is the project "Food-PPP-NAFLD" about.

stress pentose regulated outstanding biomedicine liver demonstrated protect platform combination therapies create metabolic group treatment bioactives progression groups tested pathological technically constitute recognised alcoholic interventions give optimal protected specialized vivo imbalance urgently approved odowska nadph pathologies majority damage licensed unexplored ros mouse antioxidant science curie rate vitro biology molecular discover bioactive characterise mice scenario mechanisms conceptual non almost validated fatty establishing metabolism explore enzyme cellular medication 25 diseases aging disease agonists marie throughput models enzymes redox oxidative date previously limiting ppp action modulating career disciplinary overexpression inter sk levels antagonists collaborations moderate screening prevention g6pd food host pharmacological nafld context adults compounds nutritional phosphate

Project "Food-PPP-NAFLD" data sheet

The following table provides information about the project.

Coordinator	FUNDACION IMDEA ALIMENTACION Organization address address: PABELLON CENTRAL DEL ANTIGUO HOSPITAL DE CANTOBLAN EDIFICIO NUMERO 7- CARRETERA MADRID- COLMENAR VIEJO--KILOMETRO 14 city: MADRID postcode: 28049 website: http://www.food.imdea.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	172˙932 €
EC max contribution	172˙932 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-ST
Starting year	2019
Duration (year-month-day)	from 2019-10-01 to 2021-09-30

#	participants	country	role	EC contrib. [€]
1	FUNDACION IMDEA ALIMENTACION	ES (MADRID)	coordinator	172˙932.00

FUNDACION IMDEA ALIMENTACION

ES (MADRID)

coordinator

172˙932.00

Project objective

Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults, and at present there is no approved licensed medication. Oxidative stress has been recognised as an important factor in the pathological progression of NAFLD. Therefore, therapies to protect against liver redox imbalance in the progression of this disease are urgently needed. G6PD is the rate-limiting enzyme of the pentose phosphate pathway (PPP), providing the majority of the cellular NADPH necessary for most antioxidant enzymes. The host group is specialized in nutritional interventions, metabolism and associated pathologies. They have recently demonstrated that increased levels of NADPH, induced by a moderate and regulated overexpression of G6PD, protected against aging-associated ROS oxidative damage in mice. This, in combination with the experience of the applicant in the prevention of NAFLD by using bioactives compounds, create an outstanding context for the Action. This new Marie-SkÅ‚odowska-Curie Action will explore the role of G6PD in the prevention or treatment of NAFLD. Technically, a new high-throughput screening platform will be set up to discover and characterise new food bioactive compounds modulating G6PD activity. The new bioactive compounds, as well as previously characterized pharmacological agonists/antagonists of G6PD, will be tested and validated in mouse models of NAFLD, and the mechanisms of action will be assessed using different in vitro and in vivo approaches. This Action will give further insight into the novel concept of the role of the PPP in the field of metabolic diseases, almost unexplored up to date. In addition, it will encompass a very inter-disciplinary approach including the fields of Food Science and Technology, Biomedicine and Molecular Biology, establishing collaborations with different research groups. In all, this Action will constitute a conceptual advance in the field, and will become an optimal scenario for the career development of the applicant.

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