Opendata, web and dolomites

Food-PPP-NAFLD SIGNED

Discovery and characterization of food bioactive compounds modulating the Pentose Phosphate Pathway against non-alcoholic fatty liver disease.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Food-PPP-NAFLD project word cloud

Explore the words cloud of the Food-PPP-NAFLD project. It provides you a very rough idea of what is the project "Food-PPP-NAFLD" about.

technically    moderate    liver    models    vivo    groups    biomedicine    mechanisms    overexpression    molecular    host    levels    scenario    create    25    nutritional    establishing    adults    rate    therapies    date    stress    fatty    progression    career    conceptual    platform    regulated    nadph    interventions    validated    previously    antioxidant    medication    compounds    antagonists    action    marie    protected    diseases    constitute    demonstrated    treatment    urgently    agonists    mice    non    protect    throughput    pharmacological    ros    optimal    cellular    vitro    pentose    damage    modulating    screening    curie    science    bioactive    discover    collaborations    unexplored    majority    group    recognised    explore    enzymes    odowska    aging    ppp    approved    g6pd    pathological    limiting    pathologies    prevention    bioactives    nafld    imbalance    sk    metabolic    food    licensed    oxidative    context    characterise    redox    biology    enzyme    disciplinary    mouse    specialized    combination    metabolism    phosphate    disease    almost    give    inter    tested    alcoholic    outstanding   

Project "Food-PPP-NAFLD" data sheet

The following table provides information about the project.

Coordinator
FUNDACION IMDEA ALIMENTACION 

Organization address
address: PABELLON CENTRAL DEL ANTIGUO HOSPITAL DE CANTOBLAN EDIFICIO NUMERO 7- CARRETERA MADRID- COLMENAR VIEJO--KILOMETRO 14
city: MADRID
postcode: 28049
website: http://www.food.imdea.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA ALIMENTACION ES (MADRID) coordinator 172˙932.00

Map

 Project objective

Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults, and at present there is no approved licensed medication. Oxidative stress has been recognised as an important factor in the pathological progression of NAFLD. Therefore, therapies to protect against liver redox imbalance in the progression of this disease are urgently needed. G6PD is the rate-limiting enzyme of the pentose phosphate pathway (PPP), providing the majority of the cellular NADPH necessary for most antioxidant enzymes. The host group is specialized in nutritional interventions, metabolism and associated pathologies. They have recently demonstrated that increased levels of NADPH, induced by a moderate and regulated overexpression of G6PD, protected against aging-associated ROS oxidative damage in mice. This, in combination with the experience of the applicant in the prevention of NAFLD by using bioactives compounds, create an outstanding context for the Action. This new Marie-Skłodowska-Curie Action will explore the role of G6PD in the prevention or treatment of NAFLD. Technically, a new high-throughput screening platform will be set up to discover and characterise new food bioactive compounds modulating G6PD activity. The new bioactive compounds, as well as previously characterized pharmacological agonists/antagonists of G6PD, will be tested and validated in mouse models of NAFLD, and the mechanisms of action will be assessed using different in vitro and in vivo approaches. This Action will give further insight into the novel concept of the role of the PPP in the field of metabolic diseases, almost unexplored up to date. In addition, it will encompass a very inter-disciplinary approach including the fields of Food Science and Technology, Biomedicine and Molecular Biology, establishing collaborations with different research groups. In all, this Action will constitute a conceptual advance in the field, and will become an optimal scenario for the career development of the applicant.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FOOD-PPP-NAFLD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FOOD-PPP-NAFLD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More  

CORRELATION (2020)

Characterization and prediction of service-level traffic for future sliced mobile network

Read More  

STIMOS (2019)

Stimulation of Multiple Organoids Simultaneously

Read More