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Discovery and characterization of food bioactive compounds modulating the Pentose Phosphate Pathway against non-alcoholic fatty liver disease.

Total Cost €


EC-Contrib. €






 Food-PPP-NAFLD project word cloud

Explore the words cloud of the Food-PPP-NAFLD project. It provides you a very rough idea of what is the project "Food-PPP-NAFLD" about.

context    throughput    treatment    specialized    combination    odowska    groups    liver    approved    adults    collaborations    nafld    previously    pentose    rate    biomedicine    characterise    limiting    disciplinary    aging    validated    oxidative    majority    mice    nadph    interventions    scenario    tested    career    antagonists    mouse    demonstrated    host    enzymes    group    urgently    constitute    recognised    cellular    unexplored    antioxidant    marie    pathologies    25    metabolism    explore    modulating    overexpression    science    pathological    nutritional    optimal    medication    establishing    outstanding    give    pharmacological    ppp    progression    almost    sk    redox    diseases    models    disease    discover    curie    imbalance    ros    date    g6pd    protected    action    agonists    screening    fatty    bioactive    levels    create    non    vivo    alcoholic    food    damage    biology    vitro    regulated    compounds    moderate    protect    stress    bioactives    enzyme    therapies    technically    platform    molecular    licensed    phosphate    metabolic    inter    conceptual    prevention    mechanisms   

Project "Food-PPP-NAFLD" data sheet

The following table provides information about the project.


Organization address
city: MADRID
postcode: 28049

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA ALIMENTACION ES (MADRID) coordinator 172˙932.00


 Project objective

Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults, and at present there is no approved licensed medication. Oxidative stress has been recognised as an important factor in the pathological progression of NAFLD. Therefore, therapies to protect against liver redox imbalance in the progression of this disease are urgently needed. G6PD is the rate-limiting enzyme of the pentose phosphate pathway (PPP), providing the majority of the cellular NADPH necessary for most antioxidant enzymes. The host group is specialized in nutritional interventions, metabolism and associated pathologies. They have recently demonstrated that increased levels of NADPH, induced by a moderate and regulated overexpression of G6PD, protected against aging-associated ROS oxidative damage in mice. This, in combination with the experience of the applicant in the prevention of NAFLD by using bioactives compounds, create an outstanding context for the Action. This new Marie-Skłodowska-Curie Action will explore the role of G6PD in the prevention or treatment of NAFLD. Technically, a new high-throughput screening platform will be set up to discover and characterise new food bioactive compounds modulating G6PD activity. The new bioactive compounds, as well as previously characterized pharmacological agonists/antagonists of G6PD, will be tested and validated in mouse models of NAFLD, and the mechanisms of action will be assessed using different in vitro and in vivo approaches. This Action will give further insight into the novel concept of the role of the PPP in the field of metabolic diseases, almost unexplored up to date. In addition, it will encompass a very inter-disciplinary approach including the fields of Food Science and Technology, Biomedicine and Molecular Biology, establishing collaborations with different research groups. In all, this Action will constitute a conceptual advance in the field, and will become an optimal scenario for the career development of the applicant.

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