Opendata, web and dolomites

Food-PPP-NAFLD SIGNED

Discovery and characterization of food bioactive compounds modulating the Pentose Phosphate Pathway against non-alcoholic fatty liver disease.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Food-PPP-NAFLD project word cloud

Explore the words cloud of the Food-PPP-NAFLD project. It provides you a very rough idea of what is the project "Food-PPP-NAFLD" about.

fatty    g6pd    vivo    scenario    validated    alcoholic    therapies    25    models    rate    diseases    throughput    almost    non    levels    group    disease    progression    licensed    combination    bioactives    moderate    tested    outstanding    imbalance    biology    discover    technically    vitro    odowska    inter    overexpression    action    food    molecular    nadph    career    marie    mice    science    pathological    oxidative    modulating    specialized    protected    platform    screening    phosphate    prevention    groups    metabolism    explore    constitute    cellular    compounds    create    context    characterise    medication    antioxidant    approved    unexplored    stress    mechanisms    ppp    interventions    ros    host    treatment    date    nutritional    limiting    nafld    optimal    protect    metabolic    pentose    adults    demonstrated    recognised    establishing    previously    bioactive    disciplinary    redox    pharmacological    enzymes    mouse    sk    urgently    collaborations    curie    conceptual    aging    pathologies    liver    give    biomedicine    agonists    regulated    damage    majority    enzyme    antagonists   

Project "Food-PPP-NAFLD" data sheet

The following table provides information about the project.

Coordinator
FUNDACION IMDEA ALIMENTACION 

Organization address
address: PABELLON CENTRAL DEL ANTIGUO HOSPITAL DE CANTOBLAN EDIFICIO NUMERO 7- CARRETERA MADRID- COLMENAR VIEJO--KILOMETRO 14
city: MADRID
postcode: 28049
website: http://www.food.imdea.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA ALIMENTACION ES (MADRID) coordinator 172˙932.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults, and at present there is no approved licensed medication. Oxidative stress has been recognised as an important factor in the pathological progression of NAFLD. Therefore, therapies to protect against liver redox imbalance in the progression of this disease are urgently needed. G6PD is the rate-limiting enzyme of the pentose phosphate pathway (PPP), providing the majority of the cellular NADPH necessary for most antioxidant enzymes. The host group is specialized in nutritional interventions, metabolism and associated pathologies. They have recently demonstrated that increased levels of NADPH, induced by a moderate and regulated overexpression of G6PD, protected against aging-associated ROS oxidative damage in mice. This, in combination with the experience of the applicant in the prevention of NAFLD by using bioactives compounds, create an outstanding context for the Action. This new Marie-Skłodowska-Curie Action will explore the role of G6PD in the prevention or treatment of NAFLD. Technically, a new high-throughput screening platform will be set up to discover and characterise new food bioactive compounds modulating G6PD activity. The new bioactive compounds, as well as previously characterized pharmacological agonists/antagonists of G6PD, will be tested and validated in mouse models of NAFLD, and the mechanisms of action will be assessed using different in vitro and in vivo approaches. This Action will give further insight into the novel concept of the role of the PPP in the field of metabolic diseases, almost unexplored up to date. In addition, it will encompass a very inter-disciplinary approach including the fields of Food Science and Technology, Biomedicine and Molecular Biology, establishing collaborations with different research groups. In all, this Action will constitute a conceptual advance in the field, and will become an optimal scenario for the career development of the applicant.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FOOD-PPP-NAFLD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FOOD-PPP-NAFLD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

TOPOCIRCUS (2019)

Simulations of Topological Phases in Superconducting Circuits

Read More