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Food-PPP-NAFLD SIGNED

Discovery and characterization of food bioactive compounds modulating the Pentose Phosphate Pathway against non-alcoholic fatty liver disease.

Total Cost €

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EC-Contrib. €

0

Partnership

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 Food-PPP-NAFLD project word cloud

Explore the words cloud of the Food-PPP-NAFLD project. It provides you a very rough idea of what is the project "Food-PPP-NAFLD" about.

group    enzyme    phosphate    progression    metabolic    vivo    conceptual    bioactive    25    throughput    combination    establishing    stress    outstanding    specialized    mouse    oxidative    redox    diseases    majority    aging    interventions    metabolism    fatty    non    date    create    context    modulating    demonstrated    agonists    moderate    screening    sk    nadph    medication    discover    platform    nutritional    tested    collaborations    biology    approved    models    explore    pathologies    antioxidant    treatment    technically    mechanisms    action    inter    mice    disease    rate    groups    therapies    limiting    optimal    constitute    previously    unexplored    host    antagonists    recognised    almost    pharmacological    regulated    ros    curie    science    vitro    levels    protected    g6pd    overexpression    urgently    give    prevention    protect    scenario    pentose    licensed    ppp    nafld    career    food    marie    compounds    damage    alcoholic    pathological    cellular    odowska    imbalance    adults    biomedicine    bioactives    liver    molecular    validated    characterise    disciplinary    enzymes   

Project "Food-PPP-NAFLD" data sheet

The following table provides information about the project.

Coordinator		 FUNDACION IMDEA ALIMENTACION 

Organization address
address: PABELLON CENTRAL DEL ANTIGUO HOSPITAL DE CANTOBLAN EDIFICIO NUMERO 7- CARRETERA MADRID- COLMENAR VIEJO--KILOMETRO 14
city: MADRID
postcode: 28049
website: http://www.food.imdea.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA ALIMENTACION ES (MADRID) coordinator 172˙932.00

Map

 Project objective

Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults, and at present there is no approved licensed medication. Oxidative stress has been recognised as an important factor in the pathological progression of NAFLD. Therefore, therapies to protect against liver redox imbalance in the progression of this disease are urgently needed. G6PD is the rate-limiting enzyme of the pentose phosphate pathway (PPP), providing the majority of the cellular NADPH necessary for most antioxidant enzymes. The host group is specialized in nutritional interventions, metabolism and associated pathologies. They have recently demonstrated that increased levels of NADPH, induced by a moderate and regulated overexpression of G6PD, protected against aging-associated ROS oxidative damage in mice. This, in combination with the experience of the applicant in the prevention of NAFLD by using bioactives compounds, create an outstanding context for the Action. This new Marie-Skłodowska-Curie Action will explore the role of G6PD in the prevention or treatment of NAFLD. Technically, a new high-throughput screening platform will be set up to discover and characterise new food bioactive compounds modulating G6PD activity. The new bioactive compounds, as well as previously characterized pharmacological agonists/antagonists of G6PD, will be tested and validated in mouse models of NAFLD, and the mechanisms of action will be assessed using different in vitro and in vivo approaches. This Action will give further insight into the novel concept of the role of the PPP in the field of metabolic diseases, almost unexplored up to date. In addition, it will encompass a very inter-disciplinary approach including the fields of Food Science and Technology, Biomedicine and Molecular Biology, establishing collaborations with different research groups. In all, this Action will constitute a conceptual advance in the field, and will become an optimal scenario for the career development of the applicant.

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