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CRUZIVAX SIGNED

Vaccine for prevention and treatment of Trypanosoma cruzi infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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CRUZIVAX project word cloud

Explore the words cloud of the CRUZIVAX project. It provides you a very rough idea of what is the project "CRUZIVAX" about.

humoral self safety mild poor decoy immunogenicity adjuvant trial locally cruzivax cellular economic interruption gap bridge migration antigen symptoms reducing free treatment prophylactic largely activation chronicity stimulating vi lacking unnoticed chagas chronic trypanosoma suburban human 30 limited parasitic 11 mass cardiac endemic american worldwide cruzi volunteers immunity disease 21 difficult protect immune chimeric mice facilitated strengthen efficient latin conduct cgmp first usa infection reports profile drug efficacy sequences 19 primates therapy infections formulations morbidity carriers americas acute perform combined dogs gt economics trivalent proven social million engineered active rural carry formulation settings therapeutic health restricted burden needle structure clinical became 000 critical caused pipeline preclinical healthy benznidazole models countries manufacturing vaccine performing

Project "CRUZIVAX" data sheet

The following table provides information about the project.

Coordinator	HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.helmholtz-hzi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	0 €
EC max contribution	8˙391˙240 € (0%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2018-Two-Stage-RTD
Funding Scheme	RIA-LS
Starting year	2019
Duration (year-month-day)	from 2019-06-01 to 2024-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.helmholtz-hzi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	coordinator	2˙070˙198.00
2	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	participant	963˙795.00
3	ASA SPEZIALENZYME GMBH ASA SPEZIALENZYME GMBH Organization address address: AM EXER 19 C city: WOLFENBUTTEL postcode: 38302 website: www.asa-enzyme.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WOLFENBUTTEL)	participant	951˙500.00
4	ATRC AURIGON TOXICOLOGIAI KUTATOKOZPONT KORLATOLT FELELOSSEGU TARSASAG ATRC AURIGON TOXICOLOGIAI KUTATOKOZPONT KORLATOLT FELELOSSEGU TARSASAG Organization address address: PALYA UTCA 2 city: DUNAKESZI postcode: 2120 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (DUNAKESZI)	participant	863˙592.00
5	GENIBET - BIOPHARMACEUTICALS SA GENIBET - BIOPHARMACEUTICALS SA Organization address address: AVENIDA DA REPUBLICA QUINTA DO city: OEIRAS postcode: 2781 901 website: www.genibet.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (OEIRAS)	participant	861˙249.00
6	UNIVERSIDAD DE BUENOS AIRES UNIVERSIDAD DE BUENOS AIRES Organization address address: CALLE VIAMONTE 430 city: BUENOS AIRES postcode: 1053 website: www.uba.ar contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AR (BUENOS AIRES)	participant	745˙500.00
7	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	participant	577˙302.00
8	UNIVERSIDADE NOVA DE LISBOA UNIVERSIDADE NOVA DE LISBOA Organization address address: CAMPUS DE CAMPOLIDE city: LISBOA postcode: 1099 085 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	442˙206.00
9	INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA Organization address address: AVENIDA DA REPUBLICA QUINTO DO MARQUES city: OEIRAS postcode: 2781 901 website: www.ibet.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (OEIRAS)	participant	352˙356.00
10	VAKZINE PROJEKT MANAGEMENT GMBH VAKZINE PROJEKT MANAGEMENT GMBH Organization address address: MELLENDORFER STRASSE 9 city: HANNOVER postcode: 30625 website: www.vakzine-manager.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	participant	310˙137.00
11	FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Organization address address: C ROSSELLO 132 PLANTA 05 city: BARCELONA postcode: 8036 website: www.isglobal.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	253˙401.00

Map

Project objective

Chagas is a neglected disease endemic in 21 Latin-American countries caused by Trypanosoma cruzi. It is the largest parasitic disease burden in the Americas (>11,000,000 chronic infections) and the first cause of cardiac morbidity in poor rural/suburban areas. It became a worldwide concern as a result of mass migration with reports in 19 non-endemic areas (>1.3 million carriers in EU/USA). Treatment is difficult since acute infections have mild symptoms and remain largely unnoticed evolving to chronicity. Drug therapy is also long, often associated with side effects (10-30% interruption) and only active during early infection. The main objective of CRUZIVAX is to bridge the gap between preclinical and clinical development by performing preclinical and clinical phase 1 studies of a needle-free vaccine against T. cruzi with proven efficacy in preclinical models. The vaccine is based on a structure-engineered trivalent chimeric antigen lacking immune decoy sequences and an adjuvant promoting self-limited locally-restricted immune activation stimulating humoral and cellular immunity, which is expected to protect as prophylactic or therapeutic (combined with Benznidazole) vaccine. To achieve this CRUZIVAX will: (i) conduct preclinical studies in mice to assess immunogenicity and efficacy of different vaccine formulations in prophylactic and therapeutic settings, (ii) analyse the immunogenicity and efficacy of the best vaccine formulation in dogs and non-human primates, (iii) produce cGMP antigen and adjuvant by cost-efficient manufacturing (facilitated uptake by health systems with limited resources), (iv) perform a preclinical safety assessment of the vaccine, (v) conduct a phase 1 vaccine clinical trial in healthy volunteers, and (vi) carry out a health economics analysis to identify critical target-product profile parameters. The vaccine will strengthen the pipeline of products for Chagas disease, aimed at reducing disease burden and its social and economic impact.

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