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HoloStain SIGNED

Imaging flow cytometry using holographic virtual staining

Total Cost €

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EC-Contrib. €

0

Partnership

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 HoloStain project word cloud

Explore the words cloud of the HoloStain project. It provides you a very rough idea of what is the project "HoloStain" about.

captures    camera    provides    expertise    flow    preliminary    company    commercialize    79    attractive    region    simplifying    completing    holographic    evaluation    characterizations    organelle    dictating    oncology    requirement    founding    ideal    interferometric    hematology    diagnostics    screening    cells    cytometry    multiple    bodily    capture    alone    operator    optics    quantitative    startup    marketing    fluorescently    investors    cell    projected    hemato    licensing    morphological    advantages    revolutionize    virtually    imaging    realization    channel    usd    rapid    holostain    frame    external    time    organelles    holds    2022    platform    cameras    units    staining    inaccessible    morphology    virtual    earning    dramatically    upgrading    global    add    2017    29    stained    sorting    objectiveness    portable    ifc    slices    subsequent    simultaneously    single    fluids    clinical    billion    perform    sensor    stand    manufacturers    anticipation    prototype    lack    strategic    expensive    market    accuracy    module    throughput    alpha    promise    workstation    complicated   

Project "HoloStain" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 150˙000.00

Map

 Project objective

Imaging flow cytometry (IFC) holds great promise as clinical screening and diagnostics platform, as it can capture, process and analyse a large number of cells in bodily fluids, useful for hematology and hemato-oncology. However, currently IFC captures cell morphology by imaging each fluorescently-stained cell organelle on a different region of the camera sensor, dictating complicated and expensive optics and processing units. Current IFC remains a highly inaccessible technology, due to its very high cost, lack of accuracy, required operator expertise, and lack of objectiveness. The global flow cytometry market is estimated as USD 3.29 Billion in 2017, and projected to reach USD 4.79 Billion by 2022. This rapid growth is due to anticipation of becoming more common in clinical use. In this project, we will develop and commercialize a novel IFC platform. Using an external portable interferometric module and novel analysis methods, we perform quantitative holographic virtual staining (HoloStain) of the multiple cell organelles, simultaneously on a single IFC channel, dramatically simplifying the optics, cameras, and processing. Preliminary results are provided. As HoloStain does not require cell staining for morphological evaluation, it is ideal for real-time sorting or subsequent cell use. Moreover, HoloStain provides multiple virtually stained slices from the same camera frame, earning higher throughput. These unique advantages are expected to revolutionize the IFC market in two possible product-realization pathways: (i) as a more cost-effective stand-alone IFC workstation, and (ii) as an add-on module to an existing IFC workstation, upgrading its capabilities. Both pathways are highly attractive for licensing to existing flow cytometry manufacturers or for founding a startup company. In this project, upon completing marketing requirement and product characterizations, we will build an alpha prototype, and present it to potential strategic partners and investors.

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The information about "HOLOSTAIN" are provided by the European Opendata Portal: CORDIS opendata.

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