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BioNanoLip SIGNED

Bioactive lipids at the ocular surface: from Langmuir surface balance to ophthalmic nanoemulsions

Total Cost €

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EC-Contrib. €

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Partnership

0

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Project "BioNanoLip" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO SUPERIOR TECNICO 

Organization address
address: AVENIDA ROVISCO PAIS 1
city: LISBOA
postcode: 1049-001
website: www.ist.utl.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 159˙815 €
 EC max contribution 159˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-06   to  2022-01-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO SUPERIOR TECNICO PT (LISBOA) coordinator 159˙815.00

Map

 Project objective

Since 2012 the interest to the studies of the tear film lipid layer (TFLL) stabilizing the air/tear surface has dramatically raised. Firstly TFLL related abnormalities may be the main reason for dry eye syndrome (DES), the most prevalent ophthalmic public health disease affecting the quality of life of 10-30% of the human population worldwide and resulting in > €3.5 billion annual cost for EU. Secondly due to TFLL exceptionally slow turnover rate of 0.93 (±0.36)%/min, ophthalmic nanoemulsions mixing favorably with it can gain long residence at the ocular surface allowing for new routes of treatment not only of DES but also of glaucoma, the major vision threatening disease today. Therefore it is important to study the impact of key lipid classes to the micro- and nano-scale structure and to the dynamic surface properties of TFLL films at the air/water interface in health and disease and in vitro and vivo. This is what we will do by employing state of the art Langmuir surface balance, dilatational rheology, fluorescence and Brewster angle microscopy techniques as well as pharmacokinetic methodologies. The action will deliver both, (i) fundamental knowledge on TFLL functionality and DES mechanisms and (ii) molecules and formulations that can enhance TFLL functionality and lead to new therapies. The action will allow to European science and industry to aim for leadership in a field of increasing social importance.

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The information about "BIONANOLIP" are provided by the European Opendata Portal: CORDIS opendata.

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