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BiominAB-3D SIGNED

Revealing the composition and formation mechanism of carcinogenic asbestos bodies in human lungs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 BiominAB-3D project word cloud

Explore the words cloud of the BiominAB-3D project. It provides you a very rough idea of what is the project "BiominAB-3D" about.

microdiffraction    nature    degradation    doctors    cutting    morphology    microtomography    bodies    strategies    events    particulate    imaging    tridimensional    diseases    employed    interaction    unaltered    elemental    fluorescence    respiratory    treatments    lining    fundamental    innovative    responsible    health    lung    mesothelioma    carcinogenic    pulmonary    laboratory    composition    iron    usually    breaking    fibres    tissue    edge    when    combined    nanoparticles    chemists    techniques    toxic    inhaled    mechanism    lungs    aggressive    vehicular    despite    physics    extended    structure    human    deeper    man    stay    synchrotron    science    electron    fibers    material    radiation    preserving    prevention    physicists    coating    cytotoxic    thought    chain    made    efficient    industrial    cancer    combining    revealing    triggers    incidence    medical    unprecedented    question    scientists    prolonged    biological    biologists    environment    transmission    unclear    population    asbestos    microscopy    samples    reveal   

Project "BiominAB-3D" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://biominab3d.altervista.org
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-05-22

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 180˙277.00

Map

 Project objective

When it is inhaled, asbestos triggers a chain of events that can lead to mesothelioma, an aggressive cancer of the lung lining, and to lung cancer. After prolonged stay in the lungs the asbestos fibers develop an iron coating that is thought to be responsible for the cytotoxic response, and which nature is still unclear. The fibres with their coating, developed after prolonged stay in human lungs, are known as asbestos bodies. Despite the large and increasing incidence of respiratory/pulmonary diseases among the general population due to asbestos and other toxic fibers, the carcinogenic mechanism is not yet fully understood. A deeper knowledge of the interaction between the fibers and the biological tissue can help scientists to develop more efficient medical treatments and to improve prevention strategies. The proposed research project aims to reveal the composition and formation mechanism of asbestos bodies combining cutting-edge synchrotron radiation fluorescence and imaging microtomography and microdiffraction with transmission electron microscopy. Synchrotron radiation techniques will allow revealing the elemental distribution and morphology of unaltered lung tissue samples with unprecedented level of detail, preserving their tridimensional structure. Microdiffraction and transmission electron microscopy will reveal possible degradation of the embedded asbestos fibres, which is a long standing question. The project will exploit an innovative collaboration between physicists, chemists, doctors, and biologists. In particular, physics techniques usually employed in the field of fundamental research or in material science will be combined with laboratory methodologies, creating an environment favourable for breaking-through results. The methodologies developed during the project can be extended to the study of other toxic particulate, such as vehicular or industrial particulate matter and man-made nanoparticles, which are of increasing concern for human health.

 Publications

year authors and title journal last update
List of publications.
2017 Fabrizio Bardelli, Giulia Veronesi, Silvana Capella, Donata Bellis, Laurent Charlet, Alessia Cedola, Elena Belluso
New insights on the biomineralisation process developing in human lungs around inhaled asbestos fibres
published pages: 11, ISSN: 2045-2322, DOI: 10.1038/srep44862
Scientific Reports 7/1 2019-06-13

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