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BiominAB-3D SIGNED

Revealing the composition and formation mechanism of carcinogenic asbestos bodies in human lungs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 BiominAB-3D project word cloud

Explore the words cloud of the BiominAB-3D project. It provides you a very rough idea of what is the project "BiominAB-3D" about.

nature    microtomography    iron    laboratory    medical    transmission    population    physicists    environment    microdiffraction    cytotoxic    tridimensional    morphology    human    pulmonary    mesothelioma    synchrotron    scientists    stay    science    unclear    asbestos    toxic    nanoparticles    cancer    efficient    man    prevention    employed    carcinogenic    industrial    despite    health    doctors    cutting    fluorescence    treatments    biological    interaction    techniques    bodies    lining    unaltered    preserving    material    coating    reveal    when    edge    responsible    diseases    unprecedented    lungs    revealing    particulate    physics    usually    tissue    composition    structure    radiation    lung    microscopy    inhaled    samples    thought    degradation    deeper    incidence    combined    chemists    electron    chain    biologists    events    combining    aggressive    innovative    extended    triggers    respiratory    made    prolonged    fundamental    fibers    fibres    question    elemental    vehicular    strategies    breaking    mechanism    imaging   

Project "BiominAB-3D" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://biominab3d.altervista.org
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-05-22

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 180˙277.00

Map

 Project objective

When it is inhaled, asbestos triggers a chain of events that can lead to mesothelioma, an aggressive cancer of the lung lining, and to lung cancer. After prolonged stay in the lungs the asbestos fibers develop an iron coating that is thought to be responsible for the cytotoxic response, and which nature is still unclear. The fibres with their coating, developed after prolonged stay in human lungs, are known as asbestos bodies. Despite the large and increasing incidence of respiratory/pulmonary diseases among the general population due to asbestos and other toxic fibers, the carcinogenic mechanism is not yet fully understood. A deeper knowledge of the interaction between the fibers and the biological tissue can help scientists to develop more efficient medical treatments and to improve prevention strategies. The proposed research project aims to reveal the composition and formation mechanism of asbestos bodies combining cutting-edge synchrotron radiation fluorescence and imaging microtomography and microdiffraction with transmission electron microscopy. Synchrotron radiation techniques will allow revealing the elemental distribution and morphology of unaltered lung tissue samples with unprecedented level of detail, preserving their tridimensional structure. Microdiffraction and transmission electron microscopy will reveal possible degradation of the embedded asbestos fibres, which is a long standing question. The project will exploit an innovative collaboration between physicists, chemists, doctors, and biologists. In particular, physics techniques usually employed in the field of fundamental research or in material science will be combined with laboratory methodologies, creating an environment favourable for breaking-through results. The methodologies developed during the project can be extended to the study of other toxic particulate, such as vehicular or industrial particulate matter and man-made nanoparticles, which are of increasing concern for human health.

 Publications

year authors and title journal last update
List of publications.
2017 Fabrizio Bardelli, Giulia Veronesi, Silvana Capella, Donata Bellis, Laurent Charlet, Alessia Cedola, Elena Belluso
New insights on the biomineralisation process developing in human lungs around inhaled asbestos fibres
published pages: 11, ISSN: 2045-2322, DOI: 10.1038/srep44862
Scientific Reports 7/1 2019-06-13

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The information about "BIOMINAB-3D" are provided by the European Opendata Portal: CORDIS opendata.

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