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FUNTRICAN SIGNED

Functional analysis of thyroid hormone nuclear receptors TRs in human Intestinal Cancer stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FUNTRICAN project word cloud

Explore the words cloud of the FUNTRICAN project. It provides you a very rough idea of what is the project "FUNTRICAN" about.

relapse    area    premature    human    tracing    statistically    escape    scs    worldwide    limit    techniques    thyroid    diagnosed    constitute    modification    elusive    differentiation    disrupting    risk    profound    predict    cscs    medical    demonstrated    unable    conventional    strategy    enforce    women    cancer    players    innovative    therapeutic    signature    stress    relies    prerequisite    expression    decades    deep    alpha    tumor    beta    standard    documented    csc    therapies    3d    experiments    avenues    chemotherapy    focal    adaptability    stem    recurrence    notch    issue    determinant    ratio    underlying    downstream    body    sc    cultures    parts    mechanisms    despite    eradicate    tend    cancers    hormones    minoring    organoid    vivo    radiation    colorectal    plasticity    pool    threatens    men    final    spread    crcs    bioid    intestinal    crc    ex    trs    pave    apex2    preliminary    combining    resistance    tr    proteome    reduce    balance    scores    ths    colosphere    cell    associate    wnt    original    stemness    cells    patients    life    genes    mapping    surgery   

Project "FUNTRICAN" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 116˙953 €
 EC max contribution 116˙953 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 116˙953.00

Map

 Project objective

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women worldwide. Although some CRCs are effectively treated through the standard strategy of surgery, radiation and/or chemotherapy, some patients have a recurrence of their cancer and a spread to other parts of the body that threatens life. Despite decades of research, we are unable to predict which cancers will be effectively treated and which are likely to spread. In support of the well-documented resistance of cancer stem cells (CSCs) to conventional therapies high stem cell (SC) signature scores statistically associate with a high risk of tumor relapse in patients. Targeting CSCs thus constitute a determinant medical issue and identify novel players of SC plasticity is a prerequisite to open novel therapeutic avenues. Using ex vivo organoid cultures, we recently demonstrated that thyroid hormones (THs) reduce the pool of intestinal SCs by triggering premature cell differentiation. Even if the underlying mechanisms remain elusive, our preliminary results tend to demonstrate that the TH-induced loss of stemness relies on a profound modification of the ratio between TRα1 and TRβ1 (TRs), with deep consequences on the expression of WNT and NOTCH downstream target genes. My proposal will pave the way for a unique focal area in the field of CSCs. Combining original approaches such as ex vivo 3D human colosphere and organoid cultures, in vivo CSC tracing experiments as well as innovative proteome mapping techniques (BioID and APEX2) I aim to address the potential interest of disrupting the THs/TRs balance in order to enforce CSC differentiation with the final aim to eradicate them by conventional therapies. Furthermore and more importantly, by minoring CSC plasticity, it will strongly reduce their adaptability to stress conditions and limit escape mechanisms.

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The information about "FUNTRICAN" are provided by the European Opendata Portal: CORDIS opendata.

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