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Vacc-iNTS SIGNED

Advancing a GMMA-based vaccine against invasive non-typhoidal salmonellosis through Phase 1 trial in Europe and sub-Saharan Africa

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Vacc-iNTS project word cloud

Explore the words cloud of the Vacc-iNTS project. It provides you a very rough idea of what is the project "Vacc-iNTS" about.

levels    difficult    network    vaccine    bactericidal    trial    manufacturing    experts    generalized    clinical    integration    bacteria    resource    suited    bridges    antigens    modules    saharan    deaths    transcriptomics    ints    adults    20    advocacy    biology    shigella    animals    genetically    cellular    industry    advocate    drive    deployment    sero    membrane    lt    diagnosis    preclinical    olds    invasive    academia    african    poor    data    immunogenicity    collaborative    healthy    sonnei    blebs    strains    profit    ssa    fatality    safety    accelerate    generate    263    immunogenic    vacc    typhoidal    tackling    roadblocks    salmonellosis    infectious    advancing    antibody    released    serum    endemic    epidemiological    lots    serotypes    africa    trials    enteritidis    gmma    gap    outer    scalable    countries    settings    proof    rate    rapid    followed    disease    resistance    typhimurium    antibiotic    proposes    antibodies    sub    strengthen    limited    gmp    stage    modified   

Project "Vacc-iNTS" data sheet

The following table provides information about the project.

Coordinator
SCLAVO VACCINES ASSOCIATION 

Organization address
address: PIAZZA LA LIZZA 7
city: SIENA
postcode: 53100
website: www.sclavo.org/home

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 0 €
 EC max contribution 6˙871˙188 € (0%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2018-Two-Stage-RTD
 Funding Scheme RIA-LS
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SCLAVO VACCINES ASSOCIATION IT (SIENA) coordinator 1˙152˙311.00
2    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 2˙227˙288.00
3    GSK VACCINES INSTITUTE FOR GLOBAL HEALTH SRL IT (SIENA) participant 1˙576˙515.00
4    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 545˙942.00
5    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 432˙034.00
6    UNIVERSITA DEGLI STUDI DI SIENA IT (SIENA) participant 341˙017.00
7    KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY KUMASI GH (KUMASI) participant 194˙226.00
8    UNIVERSITE OUAGA I PROFESSEUR JOSEPH KI-ZERBO BF (OUAGADOUGOU 03) participant 192˙980.00
9    KENYA MEDICAL RESEARCH INSTITUTE KE (Nairobi) participant 107˙575.00
10    UNIVERSITY OF OTAGO NZ (DUNEDIN) participant 50˙000.00
11    PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE BE (ANTWERPEN) participant 31˙296.00
12    MMGH CONSULTING GMBH CH (ZURICH) participant 20˙000.00

Map

 Project objective

Invasive non-typhoidal Salmonellosis (iNTS) is an important emerging Neglected Infectious Disease in resource-poor settings of sub-Saharan Africa (sSA). No vaccine is currently available. Estimated 263,000 iNTS deaths per year in <5 year olds, a 20% case fatality rate, difficult diagnosis and increasing antibiotic resistance strongly advocate for rapid development of an effective vaccine. Vacc-iNTS bridges the gap between preclinical and early clinical development of a novel vaccine against iNTS, based on GMMA (Generalized Modules for Membrane Antigens) from the most common African iNTS serotypes (Typhimurium and Enteritidis). The highly cost-effective GMMA-technology, developed by partner 2, is based on outer membrane blebs released by genetically modified bacteria. Clinical proof-of-concept for the GMMA-technology was achieved with a Shigella sonnei vaccine in European and African adults. In animals, iNTS-GMMA were highly immunogenic and induced antibodies with bactericidal activity against African iNTS strains. Simple, robust and scalable manufacturing processes for iNTS-GMMA, suited for sSA, have been developed. Vacc-iNTS proposes GMP manufacturing of clinical lots followed by a two-stage Phase 1 trial in healthy European and African adults to investigate safety and immunogenicity of the iNTS-GMMA vaccine. Analysis include serum antibody levels and functionality, cellular responses, transcriptomics and data integration through a systems biology approach. Sero-epidemiological analysis will be conducted to provide essential data for future Phase 2 and 3 trials. Vacc-iNTS will also strengthen a collaborative network of iNTS experts from academia, industry and non-profit including partners from disease-endemic countries of sSA. The network will generate data to accelerate further vaccine development, enhance awareness, drive advocacy and vaccine deployment in limited-resources disease-endemic countries, tackling major roadblocks in advancing a vaccine against iNTS.

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The information about "VACC-INTS" are provided by the European Opendata Portal: CORDIS opendata.

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