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GERMINOID SIGNED

Development of human primordial germ cells towards the onset of sperm and egg differentiation in a novel model culture system

Total Cost €

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EC-Contrib. €

0

Partnership

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 GERMINOID project word cloud

Explore the words cloud of the GERMINOID project. It provides you a very rough idea of what is the project "GERMINOID" about.

eggs    invented    ethical    stem    culture    independent    combined    phd    cell    wk3    supervision    students    innovative    host    reprogramming    generating    thereafter    stage    germline    simulate    benefit    organoids    preclude    differentiation    undergo    prof    generation    vivo    scientists    extend    2d    maturation    supportive    ambition    surani    germinoids    create    gastrulation    migration    human    primordial    progress    wk    hpgcs    post    extended    gonadal    implantation    onset    outcome    collaborative    breakthrough    gonads    3d    gametogenesis    vitro    hpscs    infrastructure    career    epigenetic    layer    characterization    embryos    co    hpgc    equivalent    hpsc    sperm    events    gradient    firstly    direct    team    secondly    wk2    hpgclcs    primary    intend    cells    germ    expertise    environment    primitive    lgs    fetal    model    constraints    biology    germinoid    renowned    models    pgclcs    precursors    specification    pluripotent    lab    originate   

Project "GERMINOID" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

Map

 Project objective

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate in early pre-gastrulation post-implantation embryos (~wk2). Thereafter, hPGCs undergo wide epigenetic reprogramming during their migration to the primitive gonads (~wk3–7). While technical and ethical constraints preclude direct studies on early human embryos, recent development of 2D models using human pluripotent stem cells (hPSC), which simulate early post-implantation development, have been used to investigate the specification of hPGC-like cells (PGCLCs) equivalent to wk2 hPGCs. These models however cannot support extended maturation of hPGCLCs beyond this early stage. Here, we propose a novel 3D in vitro system to advance development of hPGCLCs up to the onset of gametogenesis, extending our knowledge of the key events of early human germline development. This project will benefit from the cell culture capabilities of the three-layer gradient system (3-LGS), a 3D cell culture method that I invented during my PhD, combined with the expertise of Prof. Surani’s lab in generating hPGCLCs from hPSCs. The 3-LGS will be used to create gonadal organoids from human fetal primary cells, which we call “germinoids”, in order to support further development of hPGCLCs beyond the in vivo equivalent 2-wk stage. During this innovative project, we intend to achieve our objectives to create firstly, the novel co-culture germinoid conditions, and secondly to use the model to advance hPGCLCs differentiation. The generation and characterization of germinoids will be conducted in a collaborative team of experienced scientists and students, under renowned supervision and within a supportive and available work environment and infrastructure. This project will extend my expertise and contribute to the host’s work on early human germ cell development. The outcome will be a breakthrough in the field of human germ cell biology, which will contribute to my ambition to progress my independent research career.

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The information about "GERMINOID" are provided by the European Opendata Portal: CORDIS opendata.

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