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GERMINOID SIGNED

Development of human primordial germ cells towards the onset of sperm and egg differentiation in a novel model culture system

Total Cost €

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EC-Contrib. €

0

Partnership

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 GERMINOID project word cloud

Explore the words cloud of the GERMINOID project. It provides you a very rough idea of what is the project "GERMINOID" about.

prof    students    host    maturation    gastrulation    scientists    extended    organoids    culture    primary    infrastructure    differentiation    supportive    wk2    constraints    migration    gonadal    wk3    extend    undergo    hpsc    gradient    invented    renowned    combined    supervision    independent    3d    surani    environment    generating    simulate    gametogenesis    hpgclcs    primitive    embryos    hpgcs    intend    reprogramming    biology    sperm    wk    epigenetic    eggs    ambition    post    career    phd    cells    co    2d    preclude    germinoid    breakthrough    specification    stage    implantation    ethical    benefit    firstly    pgclcs    primordial    germ    germline    models    innovative    human    vivo    secondly    team    lab    equivalent    layer    thereafter    outcome    create    cell    fetal    germinoids    generation    onset    hpscs    collaborative    precursors    expertise    events    progress    originate    model    vitro    hpgc    characterization    lgs    stem    pluripotent    gonads    direct   

Project "GERMINOID" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

Map

 Project objective

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate in early pre-gastrulation post-implantation embryos (~wk2). Thereafter, hPGCs undergo wide epigenetic reprogramming during their migration to the primitive gonads (~wk3–7). While technical and ethical constraints preclude direct studies on early human embryos, recent development of 2D models using human pluripotent stem cells (hPSC), which simulate early post-implantation development, have been used to investigate the specification of hPGC-like cells (PGCLCs) equivalent to wk2 hPGCs. These models however cannot support extended maturation of hPGCLCs beyond this early stage. Here, we propose a novel 3D in vitro system to advance development of hPGCLCs up to the onset of gametogenesis, extending our knowledge of the key events of early human germline development. This project will benefit from the cell culture capabilities of the three-layer gradient system (3-LGS), a 3D cell culture method that I invented during my PhD, combined with the expertise of Prof. Surani’s lab in generating hPGCLCs from hPSCs. The 3-LGS will be used to create gonadal organoids from human fetal primary cells, which we call “germinoids”, in order to support further development of hPGCLCs beyond the in vivo equivalent 2-wk stage. During this innovative project, we intend to achieve our objectives to create firstly, the novel co-culture germinoid conditions, and secondly to use the model to advance hPGCLCs differentiation. The generation and characterization of germinoids will be conducted in a collaborative team of experienced scientists and students, under renowned supervision and within a supportive and available work environment and infrastructure. This project will extend my expertise and contribute to the host’s work on early human germ cell development. The outcome will be a breakthrough in the field of human germ cell biology, which will contribute to my ambition to progress my independent research career.

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