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GERMINOID SIGNED

Development of human primordial germ cells towards the onset of sperm and egg differentiation in a novel model culture system

Total Cost €

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EC-Contrib. €

0

Partnership

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 GERMINOID project word cloud

Explore the words cloud of the GERMINOID project. It provides you a very rough idea of what is the project "GERMINOID" about.

lgs    layer    hpgclcs    secondly    culture    undergo    outcome    implantation    hpsc    originate    ambition    primitive    2d    primordial    extend    progress    eggs    specification    wk3    constraints    infrastructure    gametogenesis    create    differentiation    co    host    cell    onset    gonadal    combined    germline    independent    preclude    equivalent    thereafter    events    renowned    students    post    vivo    direct    models    phd    vitro    wk2    simulate    hpgcs    gastrulation    migration    lab    innovative    sperm    wk    stem    hpgc    environment    gradient    collaborative    surani    germ    organoids    germinoids    characterization    primary    invented    biology    embryos    hpscs    intend    supervision    germinoid    benefit    stage    model    epigenetic    firstly    pluripotent    generation    supportive    generating    gonads    ethical    expertise    team    precursors    cells    extended    career    fetal    maturation    scientists    prof    pgclcs    reprogramming    human    breakthrough    3d   

Project "GERMINOID" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

Map

 Project objective

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate in early pre-gastrulation post-implantation embryos (~wk2). Thereafter, hPGCs undergo wide epigenetic reprogramming during their migration to the primitive gonads (~wk3–7). While technical and ethical constraints preclude direct studies on early human embryos, recent development of 2D models using human pluripotent stem cells (hPSC), which simulate early post-implantation development, have been used to investigate the specification of hPGC-like cells (PGCLCs) equivalent to wk2 hPGCs. These models however cannot support extended maturation of hPGCLCs beyond this early stage. Here, we propose a novel 3D in vitro system to advance development of hPGCLCs up to the onset of gametogenesis, extending our knowledge of the key events of early human germline development. This project will benefit from the cell culture capabilities of the three-layer gradient system (3-LGS), a 3D cell culture method that I invented during my PhD, combined with the expertise of Prof. Surani’s lab in generating hPGCLCs from hPSCs. The 3-LGS will be used to create gonadal organoids from human fetal primary cells, which we call “germinoids”, in order to support further development of hPGCLCs beyond the in vivo equivalent 2-wk stage. During this innovative project, we intend to achieve our objectives to create firstly, the novel co-culture germinoid conditions, and secondly to use the model to advance hPGCLCs differentiation. The generation and characterization of germinoids will be conducted in a collaborative team of experienced scientists and students, under renowned supervision and within a supportive and available work environment and infrastructure. This project will extend my expertise and contribute to the host’s work on early human germ cell development. The outcome will be a breakthrough in the field of human germ cell biology, which will contribute to my ambition to progress my independent research career.

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The information about "GERMINOID" are provided by the European Opendata Portal: CORDIS opendata.

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