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STRELECOID SIGNED

Stretchable mesh-electrodes interfacing human iPSC brain organoids

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 STRELECOID project word cloud

Explore the words cloud of the STRELECOID project. It provides you a very rough idea of what is the project "STRELECOID" about.

model    neurons    skin    mental    maturation    single    poorly    electrodes    mesh    inaccessible    code    transcriptomics    efforts    clinical    lack    vitro    electric    performed    3d    operate    donor    combination    symbiotically    unprecedented    ensembles    cortical    patient    integrate    precisely    elicit    human    pluripotent    mean    opens    neural    tissue    disorders    genetic    male    arrangements    preparations    epilepsy    psychiatric    light    biomaterials    limitation    recruit    nervous    recent    integrating    shape    thereby    signature    disease    regions    cells    successful    parkinson    brain    engineering    environment    stem    developmental    parallel    neurospheres    refined    alzheimer    animal    translate    ipsc    input    functional    expand    borne    advantages    grows    plan    sensory    humans    central    bear    seamlessly    stages    reprogram    massively    physiological    sexes    overcome    overwhelmingly    assemble    models    neurosphere    assembloids    variety    correct    possibility    cultures    donors    genome    form    thalamic    self    plasticity    animals    proximity    culture    faithful    organoids    invaluable    cell    anatomically    cellular    whereby    shed   

Project "STRELECOID" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 251˙002 €
 EC max contribution 251˙002 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 251˙002.00
2    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00

Map

 Project objective

Recent advances in cellular engineering allow to recruit skin cells from donors and reprogram them into neural stem cells. These induced pluripotent stem cells (iPSC) bear the genetic code of the human patient. Efforts to culture these cells in-vitro have been successful in creating a wide variety of 3D arrangements called neurospheres. Because the human central nervous system is by and large inaccessible at all developmental stages, these functional tissue preparations are invaluable. Furthermore, clinical studies performed in animal models are known to translate poorly to humans and therefore these systems provide unprecedented advantages: human neurons in a controlled environment that have the genetic signature of psychiatric or mental disorders borne by the donor patient, such as Alzheimer’s or Parkinson’s disease. Finally, compared to animal studies where overwhelmingly only male animals are studied, stem cell research can operate on both sexes. The combination of new biomaterials, genome engineering and massively parallel single-cell transcriptomics opens opportunities to precisely study human brain disease A new exciting development is the possibility to form so-called assembloids, whereby organoids of different brain regions, as for example cortical and thalamic neural ensembles, are brought in proximity and self-assemble into anatomically correct brain regions. These approaches are necessary to study disorders like epilepsy. However these cultures lack physiological sensory input which are key in the development of mental plasticity. Here we plan to overcome this limitation by integrating new mesh-based electrodes that integrate seamlessly into brain tissue and expand symbiotically with the neurosphere as it grows, and thereby have a spatially refined mean to measure but also elicit neural activity. This will shed light on how electric maturation of these neurospheres comes about and help shape them to an anatomically more faithful brain model.

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The information about "STRELECOID" are provided by the European Opendata Portal: CORDIS opendata.

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