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STRELECOID SIGNED

Stretchable mesh-electrodes interfacing human iPSC brain organoids

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 STRELECOID project word cloud

Explore the words cloud of the STRELECOID project. It provides you a very rough idea of what is the project "STRELECOID" about.

lack    model    preparations    form    integrating    poorly    functional    disease    grows    organoids    vitro    limitation    tissue    cultures    culture    ensembles    reprogram    humans    central    genome    light    faithful    neurosphere    signature    maturation    electrodes    overwhelmingly    stem    proximity    engineering    donors    skin    seamlessly    alzheimer    plan    symbiotically    bear    thereby    possibility    clinical    animal    successful    genetic    inaccessible    neurons    input    recent    sexes    environment    invaluable    electric    3d    massively    recruit    correct    integrate    arrangements    psychiatric    precisely    developmental    pluripotent    human    overcome    shed    whereby    regions    operate    plasticity    thalamic    neural    single    male    combination    physiological    animals    biomaterials    stages    brain    anatomically    models    refined    cortical    neurospheres    assemble    assembloids    code    mesh    sensory    donor    transcriptomics    mental    variety    elicit    unprecedented    shape    cell    parkinson    cells    ipsc    epilepsy    self    nervous    advantages    patient    expand    performed    mean    parallel    translate    opens    borne    disorders    efforts    cellular   

Project "STRELECOID" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 251˙002 €
 EC max contribution 251˙002 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 251˙002.00
2    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00

Map

 Project objective

Recent advances in cellular engineering allow to recruit skin cells from donors and reprogram them into neural stem cells. These induced pluripotent stem cells (iPSC) bear the genetic code of the human patient. Efforts to culture these cells in-vitro have been successful in creating a wide variety of 3D arrangements called neurospheres. Because the human central nervous system is by and large inaccessible at all developmental stages, these functional tissue preparations are invaluable. Furthermore, clinical studies performed in animal models are known to translate poorly to humans and therefore these systems provide unprecedented advantages: human neurons in a controlled environment that have the genetic signature of psychiatric or mental disorders borne by the donor patient, such as Alzheimer’s or Parkinson’s disease. Finally, compared to animal studies where overwhelmingly only male animals are studied, stem cell research can operate on both sexes. The combination of new biomaterials, genome engineering and massively parallel single-cell transcriptomics opens opportunities to precisely study human brain disease A new exciting development is the possibility to form so-called assembloids, whereby organoids of different brain regions, as for example cortical and thalamic neural ensembles, are brought in proximity and self-assemble into anatomically correct brain regions. These approaches are necessary to study disorders like epilepsy. However these cultures lack physiological sensory input which are key in the development of mental plasticity. Here we plan to overcome this limitation by integrating new mesh-based electrodes that integrate seamlessly into brain tissue and expand symbiotically with the neurosphere as it grows, and thereby have a spatially refined mean to measure but also elicit neural activity. This will shed light on how electric maturation of these neurospheres comes about and help shape them to an anatomically more faithful brain model.

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The information about "STRELECOID" are provided by the European Opendata Portal: CORDIS opendata.

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