Explore the words cloud of the STRELECOID project. It provides you a very rough idea of what is the project "STRELECOID" about.
The following table provides information about the project.
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
|Coordinator Country||Italy [IT]|
|Total cost||251˙002 €|
|EC max contribution||251˙002 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2019-12-01 to 2022-11-30|
Take a look of project's partnership.
|1||FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA||IT (GENOVA)||coordinator||251˙002.00|
|2||BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY||US (STANFORD)||partner||0.00|
Recent advances in cellular engineering allow to recruit skin cells from donors and reprogram them into neural stem cells. These induced pluripotent stem cells (iPSC) bear the genetic code of the human patient. Efforts to culture these cells in-vitro have been successful in creating a wide variety of 3D arrangements called neurospheres. Because the human central nervous system is by and large inaccessible at all developmental stages, these functional tissue preparations are invaluable. Furthermore, clinical studies performed in animal models are known to translate poorly to humans and therefore these systems provide unprecedented advantages: human neurons in a controlled environment that have the genetic signature of psychiatric or mental disorders borne by the donor patient, such as Alzheimer’s or Parkinson’s disease. Finally, compared to animal studies where overwhelmingly only male animals are studied, stem cell research can operate on both sexes. The combination of new biomaterials, genome engineering and massively parallel single-cell transcriptomics opens opportunities to precisely study human brain disease A new exciting development is the possibility to form so-called assembloids, whereby organoids of different brain regions, as for example cortical and thalamic neural ensembles, are brought in proximity and self-assemble into anatomically correct brain regions. These approaches are necessary to study disorders like epilepsy. However these cultures lack physiological sensory input which are key in the development of mental plasticity. Here we plan to overcome this limitation by integrating new mesh-based electrodes that integrate seamlessly into brain tissue and expand symbiotically with the neurosphere as it grows, and thereby have a spatially refined mean to measure but also elicit neural activity. This will shed light on how electric maturation of these neurospheres comes about and help shape them to an anatomically more faithful brain model.
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The information about "STRELECOID" are provided by the European Opendata Portal: CORDIS opendata.
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