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STRELECOID SIGNED

Stretchable mesh-electrodes interfacing human iPSC brain organoids

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 STRELECOID project word cloud

Explore the words cloud of the STRELECOID project. It provides you a very rough idea of what is the project "STRELECOID" about.

tissue    3d    mean    single    patient    input    preparations    sensory    advantages    code    plan    cellular    ensembles    pluripotent    assemble    stem    assembloids    cortical    culture    possibility    maturation    parkinson    environment    skin    refined    central    integrate    biomaterials    seamlessly    plasticity    transcriptomics    cultures    expand    genome    efforts    opens    animal    integrating    regions    recruit    lack    donor    functional    thalamic    performed    animals    shape    donors    variety    correct    physiological    engineering    sexes    form    neurospheres    male    cells    anatomically    overwhelmingly    bear    proximity    borne    inaccessible    neurosphere    poorly    models    disorders    shed    electric    alzheimer    humans    ipsc    model    human    elicit    neurons    vitro    precisely    symbiotically    neural    parallel    light    stages    limitation    electrodes    unprecedented    grows    brain    arrangements    massively    genetic    combination    translate    cell    operate    organoids    successful    mental    reprogram    disease    developmental    nervous    invaluable    faithful    clinical    psychiatric    recent    mesh    whereby    self    signature    thereby    overcome    epilepsy   

Project "STRELECOID" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 251˙002 €
 EC max contribution 251˙002 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 251˙002.00
2    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00

Map

 Project objective

Recent advances in cellular engineering allow to recruit skin cells from donors and reprogram them into neural stem cells. These induced pluripotent stem cells (iPSC) bear the genetic code of the human patient. Efforts to culture these cells in-vitro have been successful in creating a wide variety of 3D arrangements called neurospheres. Because the human central nervous system is by and large inaccessible at all developmental stages, these functional tissue preparations are invaluable. Furthermore, clinical studies performed in animal models are known to translate poorly to humans and therefore these systems provide unprecedented advantages: human neurons in a controlled environment that have the genetic signature of psychiatric or mental disorders borne by the donor patient, such as Alzheimer’s or Parkinson’s disease. Finally, compared to animal studies where overwhelmingly only male animals are studied, stem cell research can operate on both sexes. The combination of new biomaterials, genome engineering and massively parallel single-cell transcriptomics opens opportunities to precisely study human brain disease A new exciting development is the possibility to form so-called assembloids, whereby organoids of different brain regions, as for example cortical and thalamic neural ensembles, are brought in proximity and self-assemble into anatomically correct brain regions. These approaches are necessary to study disorders like epilepsy. However these cultures lack physiological sensory input which are key in the development of mental plasticity. Here we plan to overcome this limitation by integrating new mesh-based electrodes that integrate seamlessly into brain tissue and expand symbiotically with the neurosphere as it grows, and thereby have a spatially refined mean to measure but also elicit neural activity. This will shed light on how electric maturation of these neurospheres comes about and help shape them to an anatomically more faithful brain model.

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The information about "STRELECOID" are provided by the European Opendata Portal: CORDIS opendata.

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