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SILK-EYE SIGNED

Silk-based ocular implants: treating eye conditions at the interface of photonics and biology

Total Cost €

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EC-Contrib. €

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Partnership

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 SILK-EYE project word cloud

Explore the words cloud of the SILK-EYE project. It provides you a very rough idea of what is the project "SILK-EYE" about.

revolutionizing    biocompatibility    adding    corrective    accommodating    safer    silkworm    performed    millions    crystalline    worldwide    cocoons    replacement    bandages    functional    potentially    synthetic    protein    meets    mechanical    allografts    fibroin    versatility    ophthalmology    biomaterials    tunable    compliance    intraocular    disease    lack    prevented    cryopreservation    rejection    treatments    lens    refractive    bonding    complications    affordable    corneal    structural    amnion    additive    radically    material    silk    lenses    degradability    surgeries    found    biomaterial    exemplified    risk    implants    light    linking    designs    reduces    dressings    accessible    donor    turning    suffer    myopia    lifespan    form    generation    surgical    diseases    transmission    presbyopia    permeability    capitalizing    cornea    polymer    cross    prevalent    inlays    tuned    removal    surgery    eye    shortcomings    natural    accessibility    tissue    advantages    stiffness    index    haze    emerged    exist    transparency    biocompatible    procedure    materials    interventions   

Project "SILK-EYE" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙499˙610 €
 EC max contribution 2˙499˙610 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 2˙499˙610.00

Map

 Project objective

Prevalent eye diseases, such as myopia, presbyopia, and corneal disease affect millions worldwide, but for now cannot be prevented. Surgical interventions of these conditions are turning to additive surgery, exemplified by corneal implants or the replacement of the natural crystalline lens by (or addition of) an intraocular lens, as it reduces complications of tissue removal surgeries.

Current eye treatments involving adding tissue or lenses exist in the form of amnion bandages, corneal inlays, and intraocular lenses. However, those approaches suffer from a number of shortcomings: corneal haze or rejection; risk of disease transmission, short lifespan, need of cryopreservation and donor tissue; lack of compliance of lens designs and biomaterials. In particular, no material has been found that fully meets the requirements for mechanical properties, transparency, biocompatibility and versatility for applications in the cornea and in accommodating intraocular lenses.

In recent years, silk fibroin derived from silkworm cocoons has emerged as a protein polymer for biomaterial applications. SILK-EYE will develop a new generation of corneal and intraocular implants, using silk-based materials tuned to each specific application and light enabling procedure. The silk-based implants will feature both the accessibility advantages of synthetic materials and the structural and biocompatibility properties of allografts, capitalizing on silk’s unique potential for transparency, controllable stiffness and degradability, refractive index and permeability, and their potential for light-induced cross-linking and bonding in the eye. SILK-EYE will design radically novel corneal dressings and implants, and accommodating intraocular lenses that are more biocompatible and functional than current synthetic implants, and are safer, more tunable, accessible and affordable than donor allografts, potentially revolutionizing how the major corrective procedures in ophthalmology are performed.

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The information about "SILK-EYE" are provided by the European Opendata Portal: CORDIS opendata.

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