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SILK-EYE SIGNED

Silk-based ocular implants: treating eye conditions at the interface of photonics and biology

Total Cost €

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EC-Contrib. €

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Partnership

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 SILK-EYE project word cloud

Explore the words cloud of the SILK-EYE project. It provides you a very rough idea of what is the project "SILK-EYE" about.

replacement    designs    cornea    functional    performed    corneal    worldwide    complications    revolutionizing    transmission    shortcomings    biocompatible    transparency    accessible    cross    silk    tissue    polymer    crystalline    surgery    surgeries    fibroin    bandages    silkworm    light    material    safer    ophthalmology    removal    potentially    biocompatibility    allografts    surgical    versatility    linking    accessibility    tuned    disease    radically    lifespan    compliance    risk    dressings    meets    reduces    amnion    rejection    haze    degradability    affordable    exemplified    generation    biomaterials    capitalizing    adding    structural    refractive    lenses    stiffness    permeability    exist    found    cryopreservation    biomaterial    tunable    millions    presbyopia    interventions    corrective    synthetic    lack    index    form    implants    myopia    prevented    inlays    natural    protein    mechanical    bonding    diseases    additive    prevalent    procedure    intraocular    donor    eye    turning    advantages    materials    suffer    emerged    treatments    accommodating    lens    cocoons   

Project "SILK-EYE" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙499˙610 €
 EC max contribution 2˙499˙610 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 2˙499˙610.00

Map

 Project objective

Prevalent eye diseases, such as myopia, presbyopia, and corneal disease affect millions worldwide, but for now cannot be prevented. Surgical interventions of these conditions are turning to additive surgery, exemplified by corneal implants or the replacement of the natural crystalline lens by (or addition of) an intraocular lens, as it reduces complications of tissue removal surgeries.

Current eye treatments involving adding tissue or lenses exist in the form of amnion bandages, corneal inlays, and intraocular lenses. However, those approaches suffer from a number of shortcomings: corneal haze or rejection; risk of disease transmission, short lifespan, need of cryopreservation and donor tissue; lack of compliance of lens designs and biomaterials. In particular, no material has been found that fully meets the requirements for mechanical properties, transparency, biocompatibility and versatility for applications in the cornea and in accommodating intraocular lenses.

In recent years, silk fibroin derived from silkworm cocoons has emerged as a protein polymer for biomaterial applications. SILK-EYE will develop a new generation of corneal and intraocular implants, using silk-based materials tuned to each specific application and light enabling procedure. The silk-based implants will feature both the accessibility advantages of synthetic materials and the structural and biocompatibility properties of allografts, capitalizing on silk’s unique potential for transparency, controllable stiffness and degradability, refractive index and permeability, and their potential for light-induced cross-linking and bonding in the eye. SILK-EYE will design radically novel corneal dressings and implants, and accommodating intraocular lenses that are more biocompatible and functional than current synthetic implants, and are safer, more tunable, accessible and affordable than donor allografts, potentially revolutionizing how the major corrective procedures in ophthalmology are performed.

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The information about "SILK-EYE" are provided by the European Opendata Portal: CORDIS opendata.

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