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INO3D SIGNED

Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers

Total Cost €

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EC-Contrib. €

0

Partnership

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 INO3D project word cloud

Explore the words cloud of the INO3D project. It provides you a very rough idea of what is the project "INO3D" about.

biological    differentiation    roles    breaking    15    dna    assays    mechanisms    histone    edit    cells    octamer    remodeller    derive    regions    structures    composition    subunits    protein    nucleosomes    generates    147    shape    framework    base    expression    cell    revealing    poorly    move    protect    complexes    species    structural    barrier    explore    replication    position    wrapped    combination    maintenance    remodellers    positioning    landscape    nucleosome    carry    transformations    manner    functional    central    underlying    generating    breaks    ends    chromatin    em    arrays    machines    nuclear    mechanistic    genome    mechanical    consisting    editing    remodelling    promoter    principles    pathological    atp    collectively    pairs    megadalton    identity    understand    ino80    cryo    gene    endeavour    models    senses    free    chemo    chromosomal    fungal    ground    play    human    repair    complexity    quantitative    tool    reactions    di    fundamental    molecular    reveal    dependent    shaping   

Project "INO3D" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙201˙875 €
 EC max contribution 2˙201˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙201˙875.00

Map

 Project objective

Nucleosomes, ~147 base pairs of DNA wrapped around an histone protein octamer, package and protect nuclear DNA but also carry important biological information. The position and composition of nucleosomes along chromosomal DNA is a key element of defining the state and identity of a cell. Chromatin remodellers are ATP dependent molecular machines that position, move or edit nucleosomes in a genome wide manner. Collectively, they shape the nucleosome landscape and play central roles in the maintenance and differentiation of cells, but also in pathological transformations. INO80, a megadalton large remodeller consisting of 15 or more subunits, is involved in replication, gene expression and DNA repair. It models chromatin by positioning barrier nucleosomes around nucleosome free regions, editing nucleosomes and generating nucleosome arrays. However, structural mechanisms for INO80 and other remodelling machines are poorly understood due to their complexity. To provide a comprehensive mechanistic framework, to understand how INO80 senses nucleosome free regions to position barrier nucleosomes and how it generates arrays or senses DNA breaks, I propose a challenging but ground-breaking endeavour using a combination of cryo-EM and functional approaches. We address structures of fungal and human INO80 complexes at promoter regions, on di-nucleosomes and at DNA ends and develop quantitative positioning assays to reveal common and distinct features of shaping chromatin in different species. We also explore cryo-EM as tool towards revealing distinct steps the chemo-mechanical remodelling reactions. The proposed research will help derive fundamental molecular principles underlying the modelling of the nucleosome landscape.

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The information about "INO3D" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2020-12-05 14:00:01) correctly updated