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INO3D SIGNED

Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers

Total Cost €

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EC-Contrib. €

0

Partnership

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 INO3D project word cloud

Explore the words cloud of the INO3D project. It provides you a very rough idea of what is the project "INO3D" about.

editing    barrier    play    cells    complexity    breaking    framework    octamer    mechanistic    reactions    central    positioning    chemo    15    transformations    atp    genome    mechanisms    fungal    mechanical    nucleosome    functional    nucleosomes    endeavour    protein    dna    combination    models    composition    senses    species    protect    remodeller    biological    ino80    gene    base    147    pairs    promoter    histone    collectively    generates    replication    chromosomal    poorly    shaping    remodelling    regions    pathological    consisting    di    maintenance    tool    arrays    wrapped    subunits    expression    landscape    remodellers    manner    underlying    megadalton    molecular    carry    differentiation    machines    breaks    understand    quantitative    identity    dependent    structures    complexes    fundamental    structural    ends    cell    em    edit    generating    position    explore    roles    repair    human    reveal    derive    cryo    shape    ground    principles    nuclear    revealing    assays    move    free    chromatin   

Project "INO3D" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙201˙875 €
 EC max contribution 2˙201˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙201˙875.00

Map

 Project objective

Nucleosomes, ~147 base pairs of DNA wrapped around an histone protein octamer, package and protect nuclear DNA but also carry important biological information. The position and composition of nucleosomes along chromosomal DNA is a key element of defining the state and identity of a cell. Chromatin remodellers are ATP dependent molecular machines that position, move or edit nucleosomes in a genome wide manner. Collectively, they shape the nucleosome landscape and play central roles in the maintenance and differentiation of cells, but also in pathological transformations. INO80, a megadalton large remodeller consisting of 15 or more subunits, is involved in replication, gene expression and DNA repair. It models chromatin by positioning barrier nucleosomes around nucleosome free regions, editing nucleosomes and generating nucleosome arrays. However, structural mechanisms for INO80 and other remodelling machines are poorly understood due to their complexity. To provide a comprehensive mechanistic framework, to understand how INO80 senses nucleosome free regions to position barrier nucleosomes and how it generates arrays or senses DNA breaks, I propose a challenging but ground-breaking endeavour using a combination of cryo-EM and functional approaches. We address structures of fungal and human INO80 complexes at promoter regions, on di-nucleosomes and at DNA ends and develop quantitative positioning assays to reveal common and distinct features of shaping chromatin in different species. We also explore cryo-EM as tool towards revealing distinct steps the chemo-mechanical remodelling reactions. The proposed research will help derive fundamental molecular principles underlying the modelling of the nucleosome landscape.

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The information about "INO3D" are provided by the European Opendata Portal: CORDIS opendata.

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