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INO3D SIGNED

Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers

Total Cost €

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EC-Contrib. €

0

Partnership

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 INO3D project word cloud

Explore the words cloud of the INO3D project. It provides you a very rough idea of what is the project "INO3D" about.

147    protect    chemo    senses    ino80    collectively    models    subunits    barrier    positioning    framework    mechanisms    molecular    principles    biological    nucleosomes    dependent    reveal    octamer    arrays    understand    structures    explore    di    gene    generating    remodeller    differentiation    derive    shape    fundamental    base    maintenance    breaks    15    landscape    move    shaping    central    generates    reactions    chromatin    transformations    megadalton    ground    ends    wrapped    promoter    expression    underlying    revealing    endeavour    manner    dna    mechanical    mechanistic    quantitative    composition    free    breaking    remodelling    regions    complexes    roles    fungal    nuclear    repair    genome    functional    cell    combination    machines    chromosomal    replication    position    remodellers    species    histone    carry    nucleosome    pathological    consisting    protein    poorly    em    editing    structural    assays    cells    tool    complexity    atp    pairs    cryo    identity    human    edit    play   

Project "INO3D" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙201˙875 €
 EC max contribution 2˙201˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙201˙875.00

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 Project objective

Nucleosomes, ~147 base pairs of DNA wrapped around an histone protein octamer, package and protect nuclear DNA but also carry important biological information. The position and composition of nucleosomes along chromosomal DNA is a key element of defining the state and identity of a cell. Chromatin remodellers are ATP dependent molecular machines that position, move or edit nucleosomes in a genome wide manner. Collectively, they shape the nucleosome landscape and play central roles in the maintenance and differentiation of cells, but also in pathological transformations. INO80, a megadalton large remodeller consisting of 15 or more subunits, is involved in replication, gene expression and DNA repair. It models chromatin by positioning barrier nucleosomes around nucleosome free regions, editing nucleosomes and generating nucleosome arrays. However, structural mechanisms for INO80 and other remodelling machines are poorly understood due to their complexity. To provide a comprehensive mechanistic framework, to understand how INO80 senses nucleosome free regions to position barrier nucleosomes and how it generates arrays or senses DNA breaks, I propose a challenging but ground-breaking endeavour using a combination of cryo-EM and functional approaches. We address structures of fungal and human INO80 complexes at promoter regions, on di-nucleosomes and at DNA ends and develop quantitative positioning assays to reveal common and distinct features of shaping chromatin in different species. We also explore cryo-EM as tool towards revealing distinct steps the chemo-mechanical remodelling reactions. The proposed research will help derive fundamental molecular principles underlying the modelling of the nucleosome landscape.

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