Opendata, web and dolomites

TRYPTISSUE SIGNED

Characterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TRYPTISSUE project word cloud

Explore the words cloud of the TRYPTISSUE project. It provides you a very rough idea of what is the project "TRYPTISSUE" about.

reveal    economic    trypanosomes    reservoirs    first    surface    phenotypic    expression    editing    gene    progression    genome    species    america    glycoproteins    establishing    clinical    variability    disease    coat    proteins    evasion    fellowship    combining    colonise    dogma    parasites    roles    despite    immune    epidemics    substantial    time    trypanosoma    antigenic    african    functions    tissue    individual    severity    variant    blood    play    family    computational    super    adaptions    congolense    colonisation    variation    clustered    host    evade    tissues    interspaced    extravascular    responsible    characterise    replacement    brucei    extracellular    animal    subsequently    15    patterns    south    niches    vivax    africa    molecular    tropism    maintaining    vsg    poorly    disciplinary    though    palindromic    livestock    phylotypes    cas9    biology    divided    populations    parasite    crispr    frequent    mortality    vsgs    trypanosomiasis    linked    sequential    cell   

Project "TRYPTISSUE" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 159˙815 €
 EC max contribution 159˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 159˙815.00

Map

 Project objective

African trypanosomes (Trypanosoma brucei, T. congolense, and T. vivax) are extracellular parasites responsible for animal African trypanosomiasis, a livestock disease in Africa and South America that results in frequent epidemics, substantial animal mortality and economic loss. Parasites evade the host immune system through the sequential replacement of their surface coat of variant surface glycoproteins (VSGs). In T. congolense, the VSG super-family is divided into 15 phylotypes, which may have new functions beyond immune evasion. In this fellowship, we propose that VSGs may be important in tissue tropism. Despite being considered blood parasites, African trypanosomes colonise other tissues. The extent of extravascular colonisation and its impact in parasite development remain poorly understood, even though tissue distribution is linked to disease severity and may contribute to the large phenotypic variability observed in clinical cases. In this fellowship, I aim to study antigenic expression in distinct tissue reservoirs. First, I will characterise tissue tropism of T. congolense and T. vivax by comparing gene expression patterns of their extravascular populations. Subsequently, I will investigate the role of individual T. congolense VSG phylotypes in tissue colonisation and disease progression. To achieve this, I will establish Clustered regularly interspaced short palindromic repeats (CRISPR)-associated gene 9 (Cas9) genome editing technology for the first time in T. congolense. I propose a multi-disciplinary approach combining computational, cell, and molecular biology to reveal species-specific adaptions to tissues and the impact that particular VSG phylotypes may have in establishing or maintaining those niches. I will show that VSGs, well known proteins in trypanosomes, play important roles in disease that go beyond the classical antigenic variation dogma.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TRYPTISSUE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TRYPTISSUE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

AMPLE (2019)

A Study of the Notion of Ampleness in Model Theory and Tits Buildings

Read More  

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  

Goc-MM (2019)

Human gut microbiota on gut-on-a-chip

Read More