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TRYPTISSUE SIGNED

Characterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TRYPTISSUE project word cloud

Explore the words cloud of the TRYPTISSUE project. It provides you a very rough idea of what is the project "TRYPTISSUE" about.

phylotypes    clustered    vsgs    maintaining    evade    super    patterns    animal    substantial    africa    gene    cell    reveal    roles    time    glycoproteins    phenotypic    african    congolense    though    tissue    editing    combining    cas9    dogma    individual    characterise    interspaced    expression    palindromic    brucei    establishing    vivax    divided    colonise    subsequently    surface    parasites    frequent    populations    sequential    disease    play    vsg    family    variability    biology    blood    molecular    parasite    proteins    responsible    epidemics    poorly    progression    evasion    15    despite    linked    tropism    clinical    south    computational    genome    niches    species    immune    economic    host    crispr    severity    variation    variant    replacement    mortality    trypanosomes    america    tissues    fellowship    first    extracellular    colonisation    reservoirs    disciplinary    adaptions    antigenic    livestock    trypanosomiasis    extravascular    trypanosoma    functions    coat   

Project "TRYPTISSUE" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 159˙815 €
 EC max contribution 159˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 159˙815.00

Map

 Project objective

African trypanosomes (Trypanosoma brucei, T. congolense, and T. vivax) are extracellular parasites responsible for animal African trypanosomiasis, a livestock disease in Africa and South America that results in frequent epidemics, substantial animal mortality and economic loss. Parasites evade the host immune system through the sequential replacement of their surface coat of variant surface glycoproteins (VSGs). In T. congolense, the VSG super-family is divided into 15 phylotypes, which may have new functions beyond immune evasion. In this fellowship, we propose that VSGs may be important in tissue tropism. Despite being considered blood parasites, African trypanosomes colonise other tissues. The extent of extravascular colonisation and its impact in parasite development remain poorly understood, even though tissue distribution is linked to disease severity and may contribute to the large phenotypic variability observed in clinical cases. In this fellowship, I aim to study antigenic expression in distinct tissue reservoirs. First, I will characterise tissue tropism of T. congolense and T. vivax by comparing gene expression patterns of their extravascular populations. Subsequently, I will investigate the role of individual T. congolense VSG phylotypes in tissue colonisation and disease progression. To achieve this, I will establish Clustered regularly interspaced short palindromic repeats (CRISPR)-associated gene 9 (Cas9) genome editing technology for the first time in T. congolense. I propose a multi-disciplinary approach combining computational, cell, and molecular biology to reveal species-specific adaptions to tissues and the impact that particular VSG phylotypes may have in establishing or maintaining those niches. I will show that VSGs, well known proteins in trypanosomes, play important roles in disease that go beyond the classical antigenic variation dogma.

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The information about "TRYPTISSUE" are provided by the European Opendata Portal: CORDIS opendata.

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