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TRYPTISSUE SIGNED

Characterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TRYPTISSUE project word cloud

Explore the words cloud of the TRYPTISSUE project. It provides you a very rough idea of what is the project "TRYPTISSUE" about.

trypanosomes    evade    clustered    phenotypic    surface    first    though    fellowship    despite    15    antigenic    colonisation    glycoproteins    divided    combining    extravascular    establishing    variation    parasite    subsequently    computational    vsg    populations    individual    adaptions    severity    cas9    africa    parasites    crispr    variant    disciplinary    clinical    trypanosoma    editing    responsible    interspaced    poorly    super    niches    genome    brucei    livestock    south    palindromic    vsgs    family    sequential    progression    cell    biology    animal    reservoirs    tissue    patterns    frequent    substantial    gene    linked    colonise    trypanosomiasis    molecular    variability    phylotypes    roles    tropism    vivax    reveal    america    disease    evasion    characterise    time    mortality    species    expression    coat    proteins    functions    tissues    blood    maintaining    dogma    congolense    replacement    play    african    economic    epidemics    host    immune    extracellular   

Project "TRYPTISSUE" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 159˙815 €
 EC max contribution 159˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 159˙815.00

Map

 Project objective

African trypanosomes (Trypanosoma brucei, T. congolense, and T. vivax) are extracellular parasites responsible for animal African trypanosomiasis, a livestock disease in Africa and South America that results in frequent epidemics, substantial animal mortality and economic loss. Parasites evade the host immune system through the sequential replacement of their surface coat of variant surface glycoproteins (VSGs). In T. congolense, the VSG super-family is divided into 15 phylotypes, which may have new functions beyond immune evasion. In this fellowship, we propose that VSGs may be important in tissue tropism. Despite being considered blood parasites, African trypanosomes colonise other tissues. The extent of extravascular colonisation and its impact in parasite development remain poorly understood, even though tissue distribution is linked to disease severity and may contribute to the large phenotypic variability observed in clinical cases. In this fellowship, I aim to study antigenic expression in distinct tissue reservoirs. First, I will characterise tissue tropism of T. congolense and T. vivax by comparing gene expression patterns of their extravascular populations. Subsequently, I will investigate the role of individual T. congolense VSG phylotypes in tissue colonisation and disease progression. To achieve this, I will establish Clustered regularly interspaced short palindromic repeats (CRISPR)-associated gene 9 (Cas9) genome editing technology for the first time in T. congolense. I propose a multi-disciplinary approach combining computational, cell, and molecular biology to reveal species-specific adaptions to tissues and the impact that particular VSG phylotypes may have in establishing or maintaining those niches. I will show that VSGs, well known proteins in trypanosomes, play important roles in disease that go beyond the classical antigenic variation dogma.

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The information about "TRYPTISSUE" are provided by the European Opendata Portal: CORDIS opendata.

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