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TRYPTISSUE SIGNED

Characterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TRYPTISSUE project word cloud

Explore the words cloud of the TRYPTISSUE project. It provides you a very rough idea of what is the project "TRYPTISSUE" about.

species    individual    substantial    surface    adaptions    gene    america    tropism    colonisation    brucei    coat    patterns    vsg    clinical    progression    though    time    african    super    parasite    economic    antigenic    expression    disease    linked    mortality    evade    cas9    poorly    parasites    extracellular    variation    trypanosoma    roles    vivax    immune    animal    trypanosomiasis    reservoirs    disciplinary    reveal    despite    sequential    divided    subsequently    extravascular    tissues    first    phenotypic    populations    livestock    blood    editing    variant    15    colonise    frequent    africa    maintaining    south    variability    family    tissue    niches    palindromic    characterise    establishing    cell    congolense    functions    dogma    fellowship    phylotypes    combining    play    vsgs    epidemics    severity    genome    responsible    replacement    trypanosomes    interspaced    crispr    clustered    host    proteins    computational    biology    molecular    evasion    glycoproteins   

Project "TRYPTISSUE" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 159˙815 €
 EC max contribution 159˙815 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 159˙815.00

Map

 Project objective

African trypanosomes (Trypanosoma brucei, T. congolense, and T. vivax) are extracellular parasites responsible for animal African trypanosomiasis, a livestock disease in Africa and South America that results in frequent epidemics, substantial animal mortality and economic loss. Parasites evade the host immune system through the sequential replacement of their surface coat of variant surface glycoproteins (VSGs). In T. congolense, the VSG super-family is divided into 15 phylotypes, which may have new functions beyond immune evasion. In this fellowship, we propose that VSGs may be important in tissue tropism. Despite being considered blood parasites, African trypanosomes colonise other tissues. The extent of extravascular colonisation and its impact in parasite development remain poorly understood, even though tissue distribution is linked to disease severity and may contribute to the large phenotypic variability observed in clinical cases. In this fellowship, I aim to study antigenic expression in distinct tissue reservoirs. First, I will characterise tissue tropism of T. congolense and T. vivax by comparing gene expression patterns of their extravascular populations. Subsequently, I will investigate the role of individual T. congolense VSG phylotypes in tissue colonisation and disease progression. To achieve this, I will establish Clustered regularly interspaced short palindromic repeats (CRISPR)-associated gene 9 (Cas9) genome editing technology for the first time in T. congolense. I propose a multi-disciplinary approach combining computational, cell, and molecular biology to reveal species-specific adaptions to tissues and the impact that particular VSG phylotypes may have in establishing or maintaining those niches. I will show that VSGs, well known proteins in trypanosomes, play important roles in disease that go beyond the classical antigenic variation dogma.

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The information about "TRYPTISSUE" are provided by the European Opendata Portal: CORDIS opendata.

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