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PRIUS-TE SIGNED

Printing Ultrasound Stimulated piezoelectric materials for Tissue Engineering

Total Cost €

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EC-Contrib. €

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Partnership

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 PRIUS-TE project word cloud

Explore the words cloud of the PRIUS-TE project. It provides you a very rough idea of what is the project "PRIUS-TE" about.

adequately    life    structure    quality    society    diseased    aging    30    population    chondrocytes    isotropic    self    materials    ultrasound    chemically    cells    ecm    native    engineer    layer    cartilaginous    avascular    cellular    de    oa    clinical    unable    capability    quiescent    differentiate    electrically    significantly    diseases    osteoarthritis    mechanically    prius    form    stimulated    responsible    stem    coherent    bone    recruited    intrinsic    generating    scaffolds    on    65    ionic    mechanical    microfracture    impaired    subchondral    mainly    fixed    piezoelectric    reaching    adults    extra    content    unstructured    degeneration    defect    engineering    takes    replacements    zonal    fail    tissue    marrow    charge    organize    regenerate    te    techniques    tissues    inspiration    age    treatments    disability    rely    disregard    cartilage    cell    recruit    microenvironment    matrix    strategies    hierarchical    differentiation    progenitor    phenotypically    mimic    interface    novo    stimulate    stimulating    damage    damaged    depends    defects    older    osteochondral    character    gradient    printing   

Project "PRIUS-TE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA 

Organization address
address: BARRIO SARRIENA S N
city: LEIOA
postcode: 48940
website: www.ehu.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA ES (LEIOA) coordinator 160˙932.00

Map

 Project objective

On an aging society, our quality of life depends significantly in our capability to regenerate or engineer replacements for diseased and damaged tissues. One of these is the osteochondral interface. Over 30% of the population above the age of 65 is affected by osteochondral defects, being the most common cause of disability in older adults. PRIUS-TE (Printing Ultrasound Stimulated piezoelectric materials for Tissue Engineering) aims to regenerate the osteochondral interface with the use of hierarchical piezoelectric materials capable of stimulating mechanically, electrically and chemically the cells. Cartilage is unable to adequately self-regenerate due to its avascular character, the high content of extra cellular matrix (ECM) and the quiescent character of cells within (chondrocytes). Damage or diseases such as osteoarthritis (OA) lead to degeneration, reaching subchondral bone and generating an osteochondral defect. Clinical treatments rely on microfracture techniques that recruit tissue-specific progenitor (or stem) cells from the bone marrow, and form a de-novo cartilaginous tissue. However, the recruited cells are not able to self-organize and differentiate into phenotypically coherent cells. This results in the formation of unstructured and isotropic tissues with impaired mechanical properties that fail at long term. Current TE strategies are mainly based on isotropic materials that disregard the intrinsic multi-zonal character of the native tissue. PRIUS-TE takes inspiration from the structure and intrinsic properties of the osteochondral interface. It is based on hierarchical scaffolds that mimic the structure, cell microenvironment and fixed ionic charge responsible of the mechanical properties of the native tissue. These gradient, hierarchical and piezoelectric scaffolds will stimulate the recruited cells electrically, mechanically and chemically promoting the layer-specific cell growth, differentiation and the formation of a coherent tissue.

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The information about "PRIUS-TE" are provided by the European Opendata Portal: CORDIS opendata.

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