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PoInt SIGNED

Principles of Integrin Mechanics and Adhesion

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PoInt project word cloud

Explore the words cloud of the PoInt project. It provides you a very rough idea of what is the project "PoInt" about.

binding    signals    bonds    adaptors    blocking    cortical    hub    strategies    limiting    multifaceted    expertise    functional    adhesion    biochemical    biology    vitro    technologies    membranes    homeostasis    shape    induce    resolution    mediated    principles    first    integrate    cell    extracellular    activation    largely    multicellular    clustering    underlying    structures    forces    cluster    domains    adaptor    mechanisms    fundamental    landscapes    synergistic    assemble    organoids    molecule    regulating    proteins    output    matrix    actomyosin    decipher    completely    integrin    fibronectin    functions    spectrometers    tail    gigantic    prerequisite    cellular    complexes    combined    unravel    entire    minimal    signaling    reconstitution    kindlin    suitable    fourth    enormous    propagated    single    model    force    organ    lack    organisms    actin    talin    unknown    energy    combining    ligand    biophysical    integrins    physical    quantitative    structure    hallmark    chemical    curb    interventions   

Project "PoInt" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 7˙217˙200 €
 EC max contribution 7˙217˙200 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙371˙065.00
2    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 4˙846˙135.00

Map

 Project objective

Integrin-mediated adhesion to the extracellular matrix is a prerequisite for the development and homeostasis of multicellular organisms. A hallmark of integrins is that ligand binding requires an “integrin activation” step affecting the shape of the entire molecule is induced by the integrin tail- and actomyosin-binding adaptor proteins talin and kindlin. In a second step, integrins cluster and assemble a gigantic signaling hub, where they integrate biochemical and biophysical signals to achieve their functional output. Due to the lack of combined expertise and suitable technologies, the key steps of integrin activation are still largely unknown and the underlying physical principles still need to be identified. We propose a multifaceted approach combining quantitative single molecule measurements, reconstitution of minimal and cellular adhesion complexes as well as development of multicellular structures and organoids. We propose four aims. In our first aim we will unravel how forces are propagated through the talin-integrin tail bonds and how force-induced integrin shape changes affect signaling. In the second aim we will use novel force spectrometers to determine energy landscapes and the high-resolution structure of fibronectin-integrin complexes. In our third aim we will use in vitro model membranes to test how integrin tail-binding adaptors, cortical F-actin and specific domains of integrins induce integrin clustering. With our fourth aim we will unravel how integrins integrate chemical and biophysical signals during organ development. Using the proposed synergistic approach, we will decipher fundamental principles of cell adhesion biology. Furthermore, our research will result in a better understanding of the fundamental mechanisms regulating adhesion signaling that will allow us to develop strategies to curb adhesion functions without completely blocking integrins, thus limiting the enormous side effects of current interventions.

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The information about "POINT" are provided by the European Opendata Portal: CORDIS opendata.

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