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MRI-STRUCTURE SIGNED

MRI Signal To Recover Unique Cerebral TissUe Response to changEs

Total Cost €

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EC-Contrib. €

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Partnership

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 MRI-STRUCTURE project word cloud

Explore the words cloud of the MRI-STRUCTURE project. It provides you a very rough idea of what is the project "MRI-STRUCTURE" about.

microstructure    disease    vivo    framework    demyelination    degeneration    structure    brain    microstructural    gm    mri    secondment    models    diffusion    model    human   

Project "MRI-STRUCTURE" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme /MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 158˙121.00

Mappa

 Project objective

MRI-STRUCTURE is an innovative non-invasive imaging framework that will provide access to unexplored microstructural information in brain, targeting the scarcity of microstructural models able to extract meaningful biomarkers from the diffusion MRI signal in grey matter (GM). It is based on a synergy between different approaches: simulations, modeling, acquisition and analysis of real data, implementation of rodent model of brain insults, translation to human. The final aim of the project is to increase our knowledge of brain structure in health and disease, with a special focus on the themes of neuroinflammation, demyelination and axon degeneration. These physiological processes are interplaying phenomena involved in the brain’s reaction to different stimuli, which have recently become a hot topic in brain research, due to their involvement in the pathogenesis of several neurodegenerative and psychiatric disorders. The specific objectives of MRI-STRUCTURE are: 1) to develop a new biophysical model of diffusion MRI in GM, capturing salient aspects of its microstructure; 2) to validate the model by triggering selective activation of different compartments in selected brain areas using established models of inflammation, demyelination and degeneration in rats; 3) to translate this approach to human brain in vivo in a cohort of healthy volunteers (during a secondment in CUBRIC, one of the European hubs for neuroimaging); and 4) to disseminate the framework to a wide clinical audience through a secondment in the startup Mint Labs, and explore its commercial applicability. An instrument with capacity to characterize relevant aspects of tissue microstructure in vivo and noninvasively is expected to have a tremendous impact on our knowledge of the pathophysiology of many brain pathologies, ultimately leading to early diagnosis, better (e.g., personalised) monitoring of the disease course and of the efficacy of new therapies.

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The information about "MRI-STRUCTURE" are provided by the European Opendata Portal: CORDIS opendata.

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