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EvolSexChrom SIGNED

Testing new hypotheses on the evolution of sex-related chromosomes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EvolSexChrom project word cloud

Explore the words cloud of the EvolSexChrom project. It provides you a very rough idea of what is the project "EvolSexChrom" about.

modeling    paradigm    alleles    compatibility    unearthed    regions    potentially    neutral    genetic    rearrangements    recombination    transposable    generally    extension    mathematical    chromosomes    diverse    chromosome    opening    female    sexual    strata    nevertheless    sex    synergic    shown    plants    beneficial    epigenetic    recombining    broaden    combinations    generating    biological    evolution    prevailing    unclear    linked    hypotheses    refine    hypothesis    little    evolutionary    theory    attractive    stepwise    display    generate    experimental    mating    innovative    mechanisms    dynamic    decades    linkage    near    shift    differentiation    contain    population    explanation    accumulating    animals    functional    lacking    traits    cessation    genes    predictions    avenues    deleterious    alternative    evolsexchrom    supergenes    suppression    genomic    functions    sheltering    allelic    plausible    seriously    organisms    male    antagonism    manipulations    combination    evolve    plausibility   

Project "EvolSexChrom" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙500˙000.00

Map

 Project objective

The sex chromosomes of plants and animals often contain large non-recombining regions due to a stepwise cessation of recombination generating “evolutionary strata” of genetic differentiation. The reasons for the extension of recombination suppression beyond sex-determining genes remain unclear. Sexual antagonism, involving the linkage to sex-determining genes of alleles beneficial in only one sex, is the prevailing hypothesis, as this explanation is both theoretically plausible and attractive. However, decades of research have unearthed little evidence to support this hypothesis. Furthermore, I have shown that chromosomes involved in sexual compatibility in systems lacking male and female functions can nevertheless display a stepwise suppression of recombination beyond mating-compatibility genes. Thus, evolutionary strata can evolve without sexual antagonism. Alternative hypotheses, such as neutral rearrangements, epigenetic changes associated with transposable elements and the sheltering of deleterious alleles accumulating near non-recombining regions, must thus be seriously considered. I propose to use a synergic combination of different approaches and biological systems to refine and test these hypotheses, to broaden the theory of sex-related chromosome evolution, and, more generally, of the evolution of supergenes (linked allelic combinations). I will use mathematical modeling to test hypothesis plausibility and generate predictions. I will use comparative and population genomic approaches to test predictions, and an innovative experimental evolution approach with functional manipulations to assess the ability of the proposed mechanisms to generate strata. The EvolSexChrom project will challenge the current theory, opening up new avenues of research and potentially creating a paradigm shift in the dynamic research field focusing on the evolution of sex-related chromosomes and other supergenes, relevant to diverse traits and organisms.

 Publications

year authors and title journal last update
List of publications.
2019 Fanny E Hartmann, Ricardo C Rodríguez de la Vega, Pierre Gladieux, Wen-Juan Ma, Michael E Hood, Tatiana Giraud
Higher gene flow in sex-related chromosomes than in autosomes during fungal divergence
published pages: , ISSN: 0737-4038, DOI: 10.1093/molbev/msz252
Molecular Biology and Evolution 2019-11-07

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