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EvolSexChrom SIGNED

Testing new hypotheses on the evolution of sex-related chromosomes

Total Cost €

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EC-Contrib. €

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Partnership

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 EvolSexChrom project word cloud

Explore the words cloud of the EvolSexChrom project. It provides you a very rough idea of what is the project "EvolSexChrom" about.

mathematical    potentially    near    differentiation    female    innovative    evolve    unclear    functional    organisms    predictions    decades    rearrangements    recombining    linked    broaden    genes    suppression    evolsexchrom    synergic    generally    stepwise    nevertheless    shift    population    avenues    prevailing    chromosome    dynamic    plausible    seriously    transposable    compatibility    mechanisms    contain    lacking    combination    refine    strata    animals    plants    neutral    shown    display    modeling    recombination    opening    mating    sheltering    little    accumulating    experimental    extension    male    genetic    functions    cessation    genomic    epigenetic    hypotheses    alleles    linkage    attractive    generate    traits    antagonism    unearthed    allelic    paradigm    chromosomes    regions    generating    deleterious    biological    alternative    theory    evolutionary    supergenes    beneficial    plausibility    hypothesis    manipulations    sex    sexual    evolution    diverse    explanation    combinations   

Project "EvolSexChrom" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙500˙000.00

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 Project objective

The sex chromosomes of plants and animals often contain large non-recombining regions due to a stepwise cessation of recombination generating “evolutionary strata” of genetic differentiation. The reasons for the extension of recombination suppression beyond sex-determining genes remain unclear. Sexual antagonism, involving the linkage to sex-determining genes of alleles beneficial in only one sex, is the prevailing hypothesis, as this explanation is both theoretically plausible and attractive. However, decades of research have unearthed little evidence to support this hypothesis. Furthermore, I have shown that chromosomes involved in sexual compatibility in systems lacking male and female functions can nevertheless display a stepwise suppression of recombination beyond mating-compatibility genes. Thus, evolutionary strata can evolve without sexual antagonism. Alternative hypotheses, such as neutral rearrangements, epigenetic changes associated with transposable elements and the sheltering of deleterious alleles accumulating near non-recombining regions, must thus be seriously considered. I propose to use a synergic combination of different approaches and biological systems to refine and test these hypotheses, to broaden the theory of sex-related chromosome evolution, and, more generally, of the evolution of supergenes (linked allelic combinations). I will use mathematical modeling to test hypothesis plausibility and generate predictions. I will use comparative and population genomic approaches to test predictions, and an innovative experimental evolution approach with functional manipulations to assess the ability of the proposed mechanisms to generate strata. The EvolSexChrom project will challenge the current theory, opening up new avenues of research and potentially creating a paradigm shift in the dynamic research field focusing on the evolution of sex-related chromosomes and other supergenes, relevant to diverse traits and organisms.

 Publications

year authors and title journal last update
List of publications.
2019 Fanny E Hartmann, Ricardo C Rodríguez de la Vega, Pierre Gladieux, Wen-Juan Ma, Michael E Hood, Tatiana Giraud
Higher gene flow in sex-related chromosomes than in autosomes during fungal divergence
published pages: , ISSN: 0737-4038, DOI: 10.1093/molbev/msz252
Molecular Biology and Evolution 2019-11-07

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