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IMpaCT SIGNED

Imaging life from Molecules to cells - building knowledge on Cryo-electron microscopy methodologies

Total Cost €

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EC-Contrib. €

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Partnership

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 IMpaCT project word cloud

Explore the words cloud of the IMpaCT project. It provides you a very rough idea of what is the project "IMpaCT" about.

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Project "IMpaCT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 800˙000 €
 EC max contribution 800˙000 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-2018-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 412˙616.00
2    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 146˙316.00
3    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 141˙043.00
4    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 100˙023.00

Map

 Project objective

Proteins are building blocks of life, often forming complexes with essential cellular roles. Dysfunction of proteins or their complexes in cells are associated with a wide variety of pathologies, making them excellent drug target candidates. Their 3D structures are essential for a rational drug design. However, many important proteins and complexes are extremely hard to crystallize. Recent advances in Cryo-Electron Microscopy methodologies enabled the structure determination of large macromolecular complexes at near-atomic resolution. An unprecedented level of detail in cell imaging using Cryo-Electron Tomography is also now possible. IMpaCT will improve the expertise at the UNL in Cryo-EM methodologies applied to the structural studies of proteins related to human health (e.g. cancer, antiviral infections) from individual molecules to macromolecular complexes, both isolated and in a cellular context. To this end, UNL will team up with renowned Cryo-EM experts from the National Centre for Biotechnology of the Spanish National Research Council (Spain), the Institute of Biotechnology of the University of Helsinki (Finland) and the Weizmann Institute of Science (Israel). A solid work programme grounded on hands-on Workshops will be complemented with short-term visits to the partner labs, visits from partner labs experts to ITQB NOVA, seminars by leading experts in Cryo-EM (e.g. Nobel Prize winners), industry stakeholders’ engagement via a Mini-symposium and workshop participation, knowledge transfer to other research groups in Portugal and a WP devoted to early-stage researchers. An ambitious Dissemination, Exploitation and Communication plan will be implemented to leverage the research results potentiated by this project as high-impact publications and invited communications at international meetings, leading to a fundamental outcome: an increased visibility and activity of UNL researchers as players in the Cryo-EM field.

 Publications

year authors and title journal last update
List of publications.
2017 Márcia Alves, Nicole S.M. Vieira, Luís Paulo N. Rebelo, João M.M. Araújo, Ana B. Pereiro, Margarida Archer
Fluorinated ionic liquids for protein drug delivery systems: Investigating their impact on the structure and function of lysozyme
published pages: 309-320, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2017.05.002
International Journal of Pharmaceutics 526/1-2 2019-10-30
2019 Maria C. Martins, Célia V. Romão, Filipe Folgosa, Patrícia T. Borges, Carlos Frazão, Miguel Teixeira
How superoxide reductases and flavodiiron proteins combat oxidative stress in anaerobes
published pages: 36-60, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.01.051
Free Radical Biology and Medicine 140 2019-10-30
2018 Saúl Silva, Osvaldo S. Ascenso, Eva C. Lourenço, Margarida Archer, Christopher D. Maycock, M. Rita Ventura
Syntheses of the plant auxin conjugate 2- O -(indole-3-acetyl)- myo -inositol IAInos
published pages: 6860-6864, ISSN: 1477-0520, DOI: 10.1039/c8ob02096e
Organic & Biomolecular Chemistry 16/38 2019-10-30
2019 Inês B. Trindade, José M. Silva, Bruno M. Fonseca, Teresa Catarino, Masaki Fujita, Pedro M. Matias, Elin Moe, Ricardo O. Louro
Structure and reactivity of a siderophore-interacting protein from the marine bacterium Shewanella reveals unanticipated functional versatility
published pages: 157-167, ISSN: 0021-9258, DOI: 10.1074/jbc.ra118.005041
Journal of Biological Chemistry 294/1 2019-10-30
2017 Thomas L. Clarke, Maria Pilar Sanchez-Bailon, Kelly Chiang, John J. Reynolds, Joaquin Herrero-Ruiz, Tiago M. Bandeiras, Pedro M. Matias, Sarah L. Maslen, J. Mark Skehel, Grant S. Stewart, Clare C. Davies
PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination
published pages: 900-916.e7, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.01.019
Molecular Cell 65/5 2019-10-30
2018 Alessandro Giuffrè, João B. Vicente
Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology
published pages: 1-31, ISSN: 1942-0900, DOI: 10.1155/2018/6290931
Oxidative Medicine and Cellular Longevity 2018 2019-10-30
2019 Karim Zuhra, Pedro M. F. Sousa, Giulia Paulini, Ana Rita Lemos, Zenta Kalme, Imants Bisenieks, Egils Bisenieks, Brigita Vigante, Gunars Duburs, Tiago M. Bandeiras, Luciano Saso, Alessandro Giuffrè, João B. Vicente
Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-36994-w
Scientific Reports 9/1 2019-10-30
2018 Elin Moe, Filipe Rollo, Célia M. Silveira, Murat Sezer, Peter Hildebrandt, Smilja Todorovic
Spectroelectrochemical insights into structural and redox properties of immobilized endonuclease III and its catalytically inactive mutant
published pages: 149-154, ISSN: 1386-1425, DOI: 10.1016/j.saa.2017.06.050
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 188 2019-10-30
2019 Karim Zuhra, Catarina S. Tomé, Letizia Masi, Giorgio Giardina, Giulia Paulini, Francesca Malagrinò, Elena Forte, João B. Vicente, Alessandro Giuffrè
N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells
published pages: 828, ISSN: 2073-4409, DOI: 10.3390/cells8080828
Cells 8/8 2019-10-30
2019 Francesca Malagrinò, Karim Zuhra, Ludovica Mascolo, Daniela Mastronicola, João B. Vicente, Elena Forte, Alessandro Giuffrè
Hydrogen Sulfide Oxidation: Adaptive Changes in Mitochondria of SW480 Colorectal Cancer Cells upon Exposure to Hypoxia
published pages: 1-11, ISSN: 1942-0900, DOI: 10.1155/2019/8102936
Oxidative Medicine and Cellular Longevity 2019 2019-10-30
2019 Sónia Zacarias, Adriana Temporão, Melisa del Barrio, Vincent Fourmond, Christophe Léger, Pedro M. Matias, Inês A. C. Pereira
A Hydrophilic Channel Is Involved in Oxidative Inactivation of a [NiFeSe] Hydrogenase
published pages: 8509-8519, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b02347
ACS Catalysis 9/9 2019-10-30
2016 João B. Vicente, Francesca Malagrinò, Marzia Arese, Elena Forte, Paolo Sarti, Alessandro Giuffrè
Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase
published pages: 1127-1138, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2016.03.030
Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857/8 2019-10-30
2019 Aili Sarre, Meike Stelter, Filipe Rollo, Salvatore De Bonis, Anna Seck, Cécilia Hognon, Jean-Luc Ravanat, Antonio Monari, François Dehez, Elin Moe, Joanna Timmins
The three Endonuclease III variants of Deinococcus radiodurans possess distinct and complementary DNA repair activities
published pages: 45-59, ISSN: 1568-7864, DOI: 10.1016/j.dnarep.2019.03.014
DNA Repair 78 2019-10-30
2016 Eduardo F. P. Ruivo, Lídia M. Gonçalves, Luís A. R. Carvalho, Rita C. Guedes, Stefan Hofbauer, José A. Brito, Margarida Archer, Rui Moreira, Susana D. Lucas
Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes
published pages: 2037-2042, ISSN: 1860-7179, DOI: 10.1002/cmdc.201600258
ChemMedChem 11/18 2019-10-30
2017 M. Amaral, D. B. Kokh, J. Bomke, A. Wegener, H. P. Buchstaller, H. M. Eggenweiler, P. Matias, C. Sirrenberg, R. C. Wade, M. Frech
Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02258-w
Nature Communications 8/1 2019-10-30
2016 Célia V. Romão, João B. Vicente, Patrícia T. Borges, Bruno L. Victor, Pedro Lamosa, Elísio Silva, Luís Pereira, Tiago M. Bandeiras, Cláudio M. Soares, Maria A. Carrondo, David Turner, Miguel Teixeira, Carlos Frazão
Structure of Escherichia coli Flavodiiron Nitric Oxide Reductase
published pages: 4686-4707, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2016.10.008
Journal of Molecular Biology 428/23 2019-10-30
2019 Bruno M. Fonseca, Luís Silva, Inês B. Trindade, Elin Moe, Pedro M. Matias, Ricardo O. Louro, Catarina M. Paquete
Optimizing Electroactive Organisms: The Effect of Orthologous Proteins
published pages: , ISSN: 2296-598X, DOI: 10.3389/fenrg.2019.00002
Frontiers in Energy Research 7 2019-10-30
2018 Célia V. Romão, Pedro M. Matias, Cristiana M. Sousa, Filipa G. Pinho, Ana F. Pinto, Miguel Teixeira, Tiago M. Bandeiras
Insights into the Structures of Superoxide Reductases from the Symbionts Ignicoccus hospitalis and Nanoarchaeum equitans
published pages: 5271-5281, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.8b00334
Biochemistry 57/36 2019-10-30
2016 Inês B. Trindade, Bruno M. Fonseca, Pedro M. Matias, Ricardo O. Louro, Elin Moe
A putative siderophore-interacting protein from the marine bacterium Shewanella frigidimarina NCIMB 400: cloning, expression, purification, crystallization and X-ray diffraction analysis
published pages: 667-671, ISSN: 2053-230X, DOI: 10.1107/s2053230x16011419
Acta Crystallographica Section F Structural Biology Communications 72/9 2019-10-30
2017 Luis Pereira, Ivo H. Saraiva, A. Sofia F. Oliveira, Cláudio M. Soares, Ricardo O. Louro, Carlos Frazão
Molecular structure of FoxE, the putative iron oxidase of Rhodobacter ferrooxidans SW2
published pages: 847-853, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2017.07.002
Biochimica et Biophysica Acta (BBA) - Bioenergetics 1858/10 2019-10-30
2018 Sara T. N. Silva, José A. Brito, Rocío Arranz, Carlos Óscar S. Sorzano, Christine Ebel, James Doutch, Mark D. Tully, José-María Carazo, José L. Carrascosa, Pedro M. Matias, Tiago M. Bandeiras
X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-31997-z
Scientific Reports 8/1 2019-10-30
2017 Filipe M. Sousa, Filipa V. Sena, Ana P. Batista, Diogo Athayde, José A. Brito, Margarida Archer, A. Sofia F. Oliveira, Cláudio M. Soares, Teresa Catarino, Manuela M. Pereira
The key role of glutamate 172 in the mechanism of type II NADH:quinone oxidoreductase of Staphylococcus aureus
published pages: 823-832, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2017.08.002
Biochimica et Biophysica Acta (BBA) - Bioenergetics 1858/10 2019-10-30
2019 Patrícia T. Borges, Célia V. Romão, Lígia M. Saraiva, Vera L. Gonçalves, Maria A. Carrondo, Miguel Teixeira, Carlos Frazão
Analysis of a new flavodiiron core structural arrangement in Flv1-ΔFlR protein from Synechocystis sp. PCC6803
published pages: 91-102, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2018.11.004
Journal of Structural Biology 205/1 2019-10-30
2017 Ana I. Coelho, M. Estela Rubio-Gozalbo, João B. Vicente, Isabel Rivera
Sweet and sour: an update on classic galactosemia
published pages: 325-342, ISSN: 0141-8955, DOI: 10.1007/s10545-017-0029-3
Journal of Inherited Metabolic Disease 40/3 2019-10-30
2016 Susana A.L. Lobo, Marco A.M. Videira, Isabel Pacheco, Mark N. Wass, Martin J. Warren, Miguel Teixeira, Pedro M. Matias, Célia V. Romão, Lígia M. Saraiva
Desulfovibrio vulgaris CbiK P cobaltochelatase: evolution of a haem binding protein orchestrated by the incorporation of two histidine residues
published pages: 106-118, ISSN: 1462-2912, DOI: 10.1111/1462-2920.13479
Environmental Microbiology 19/1 2019-10-30
2016 Joanna Timmins, Elin Moe
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges
published pages: 168-176, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2016.04.001
Computational and Structural Biotechnology Journal 14 2019-10-30
2017 Marta C Marques, Cristina Tapia, Oscar Gutiérrez-Sanz, Ana Raquel Ramos, Kimberly L Keller, Judy D Wall, Antonio L De Lacey, Pedro M Matias, Inês A C Pereira
The direct role of selenocysteine in [NiFeSe] hydrogenase maturation and catalysis
published pages: 544-550, ISSN: 1552-4450, DOI: 10.1038/nchembio.2335
Nature Chemical Biology 13/5 2019-10-30
2017 Sandra P. Santos, Maxime G. Cuypers, Adam Round, Stephanie Finet, Theyencheri Narayanan, Edward P. Mitchell, Célia V. Romão
SAXS Structural Studies of Dps from Deinococcus radiodurans Highlights the Conformation of the Mobile N-Terminal Extensions
published pages: 667-687, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2017.01.008
Journal of Molecular Biology 429/5 2019-10-30
2016 Julia M. Kurth, José A. Brito, Jula Reuter, Alexander Flegler, Tobias Koch, Thomas Franke, Eva-Maria Klein, Sam F. Rowe, Julea N. Butt, Kevin Denkmann, Inês A. C. Pereira, Margarida Archer, Christiane Dahl
Electron Accepting Units of the Diheme Cytochrome c TsdA, a Bifunctional Thiosulfate Dehydrogenase/Tetrathionate Reductase
published pages: 24804-24818, ISSN: 0021-9258, DOI: 10.1074/jbc.m116.753863
Journal of Biological Chemistry 291/48 2019-10-30
2017 João B. Vicente, Henrique G. Colaço, Francesca Malagrinò, Paulo E. Santo, André Gutierres, Tiago M. Bandeiras, Paula Leandro, José A. Brito, Alessandro Giuffrè
A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?
published pages: 1-13, ISSN: 1942-0900, DOI: 10.1155/2017/8940321
Oxidative Medicine and Cellular Longevity 2017 2019-10-30
2018 Kelly Stefany Tuna Frade, Andreia Cecília Pimenta Fernandes, Celia Marisa Silveira, Carlos Frazão, Elin Moe
A novel bacterial class V dye-decolourizing peroxidase from the extremophile Deinococcus radiodurans : cloning, expression optimization, purification, crystallization, initial characterization and X-ray diffraction analysis
published pages: 419-424, ISSN: 2053-230X, DOI: 10.1107/s2053230x18008488
Acta Crystallographica Section F Structural Biology Communications 74/7 2019-10-30
2018 M. Cecília Almadanim, Nuno M. Gonçalves, Margarida T.G. Rosa, Bruno M. Alexandre, André M. Cordeiro, Mafalda Rodrigues, Nelson J.M. Saibo, Cláudio M. Soares, Célia V. Romão, M. Margarida Oliveira, Isabel A. Abreu
The rice cold-responsive calcium-dependent protein kinase OsCPK17 is regulated by alternative splicing and post-translational modifications
published pages: 231-246, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2017.10.010
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865/2 2019-10-30

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