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LONGITOOLS SIGNED

Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases

Total Cost €

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EC-Contrib. €

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Partnership

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 LONGITOOLS project word cloud

Explore the words cloud of the LONGITOOLS project. It provides you a very rough idea of what is the project "LONGITOOLS" about.

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Project "LONGITOOLS" data sheet

The following table provides information about the project.

Coordinator
OULUN YLIOPISTO 

Organization address
address: PENTTI KAITERAN KATU 1
city: OULU
postcode: 90014
website: www.oulu.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 11˙997˙448 €
 EC max contribution 11˙997˙448 € (100%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OULUN YLIOPISTO FI (OULU) coordinator 1˙171˙875.00
2    ITA-SUOMEN YLIOPISTO FI (KUOPIO) participant 987˙595.00
3    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 896˙160.00
4    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 808˙992.00
5    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 796˙910.00
6    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 729˙781.00
7    UNIVERSITAT DE BARCELONA ES (BARCELONA) participant 716˙250.00
8    UNIVERSITY OF SURREY UK (GUILDFORD) participant 682˙347.00
9    BETA TECHNOLOGY LTD UK (DONCASTER) participant 647˙870.00
10    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) participant 600˙625.00
11    AB.ACUS SRL IT (MILANO) participant 574˙125.00
12    UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA IT (ROMA) participant 555˙125.00
13    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 552˙321.00
14    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 524˙257.00
15    UNIVERSITETET I OSLO NO (OSLO) participant 500˙942.00
16    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 451˙375.00
17    CHALMERS TEKNISKA HOEGSKOLA AB SE (GOETEBORG) participant 427˙941.00
18    CYNEXO SRL IT (TRIVIGNANO UDINESE) participant 372˙955.00

Map

 Project objective

Environmental factors, including air and noise pollution, and the built environment, are typically associated with cardiovascular and metabolic non-communicable diseases (NCDs), e.g. obesity, type 2 diabetes, heart diseases and atherosclerosis. The extent to which these exposures may cause their attributed health effects (via molecular mediation) directly or indirectly as a result of associations to an individual’s psychosocial context is largely unknown. NCDs arise from a lifelong process influencing anthropometric, glycaemic, cardiac and lipid-related health trajectories. Risks may start as early as during the fetal period and are modified during sensitive periods in childhood, adolescence and adulthood. Despite this, research has not focused enough on the life-course characterisation of the exposome and the application of this to health and disease. In 5 years, LONGITOOLS, a partnership of 15 academic groups and 3 small companies will harness a catalogue of birth cohorts, longitudinal data, registers and biobanks. We will characterise coincident longitudinal trajectories of exposure and cardiometabolic health combining the study of longitudinal effects and internal responses. The latter will include measures of DNA methylation, RNA expression and read outs of metabolic pathways. LONGITOOLS will implement this longitudinal approach in 11 work packages designed to generate a catalogue of FAIR data and a novel analytical toolbox. Evidence-based life-course causal models will estimate how clinical and policy interventions may sustainably affect the health and economic burden of NCDs. A key objective will be to generate evidence-based predictions which can ultimately translate into innovative healthcare applications (apps) and policy options. LONGITOOLS will also allow researchers and policy makers to generate new knowledge - identifying the likely causal (direct and indirect) mechanisms through which exposures to man-made environmental factors affect the risk of NCDs. LONGITOOLS is one of the nine projects composing the European Human Exposome Network.

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The information about "LONGITOOLS" are provided by the European Opendata Portal: CORDIS opendata.

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