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Opendata, web and dolomites

DrugPhosphoProfiler SIGNED

Accelerating drug and biomarker discovery through a new proteomic service: DrugPhosphoProfiler

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

DrugPhosphoProfiler project word cloud

Explore the words cloud of the DrugPhosphoProfiler project. It provides you a very rough idea of what is the project "DrugPhosphoProfiler" about.

team at comprehensiveness unmet systematically biological difficult roi huge toxicity discovery clinical cellular trials tool platform proteome network 12 faster protein solution mechanism critical efficient content detection 6m biomarkers sites limits drug disease 25 manner throughput overcome drugphosphoprofiler robustness data ms unfortunately consequently molecular revenues competitiveness clear pharmacodynamic networks specificity generating innovative single unable measuring signalling antibody action mass phosphorylation commercialization rate idea drugs sensitivity people therapeutic compromising complexity treatment dependent quantitative agents omicscouts boost resolved implication company pathologies 27 sme pharmaceutical industry spectrometry assay germany concentration

Project "DrugPhosphoProfiler" data sheet

The following table provides information about the project.

Coordinator	OMICSCOUTS GMBH Organization address address: LISE-MEITNER-STRASSE 30 city: FREISING postcode: 85354 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://omicscouts.com/en/
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-1
Funding Scheme	SME-1
Starting year	2019
Duration (year-month-day)	from 2019-08-01 to 2019-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OMICSCOUTS GMBH OMICSCOUTS GMBH Organization address address: LISE-MEITNER-STRASSE 30 city: FREISING postcode: 85354 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREISING)	coordinator	50˙000.00

Map

Project objective

At present there is a huge interest in the pharmaceutical industry to find and develop new drugs targeting protein phosphorylation and their related biological pathways, due to the critical implication of these processes in many pathologies. The high complexity of these phosphorylation-dependent cellular signalling network makes very difficult to have a clear idea about the mechanism of action of a particular drug as well as its side effects. Unfortunately, existing approaches are unable to provide comprehensive, robust and quantitative data of cellular phosphorylation needed to support faster and more efficient drug discovery and development. Consequently, there is a large and unmet need in the pharmaceutical industry for identifying related therapeutic, toxicity targets and biomarkers, in order to develop better drugs. We are developing DrugPhosphoProfiler, an innovative mass spectrometry (MS)-based high-throughput platform for systematically measuring the effects of pharmaceutical agents on phosphorylation-dependent cellular networks in a proteome-wide and drug concentration-resolved manner. DrugPhosphoProfiler will be a unique, high-content drug discovery and development tool capable of providing essential and quantitative molecular pharmacodynamic data based on 25,000 phosphorylation sites in a single assay. The information obtained by our solution will go far beyond existing antibody-based detection systems and overcome their limits in terms of specificity and comprehensiveness without compromising sensitivity and robustness. DrugPhosphoProfiler will thus increase the success rate of pre-clinical drug discovery as well as clinical trials and eventually lead to more effective treatment of disease. Through this project (estimated ROI of 6), we at OmicScouts (SME, Germany) aim to boost the competitiveness of our company, by generating €8.6M revenues and increasing our team to 27 people (from 12), just 5 years after commercialization.

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The information about "DRUGPHOSPHOPROFILER" are provided by the European Opendata Portal: CORDIS opendata.

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