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DrugPhosphoProfiler SIGNED

Accelerating drug and biomarker discovery through a new proteomic service: DrugPhosphoProfiler

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DrugPhosphoProfiler project word cloud

Explore the words cloud of the DrugPhosphoProfiler project. It provides you a very rough idea of what is the project "DrugPhosphoProfiler" about.

omicscouts biomarkers manner difficult phosphorylation toxicity specificity 27 huge trials throughput compromising competitiveness sme measuring robustness antibody data single mass agents faster 6m platform cellular germany action quantitative pharmacodynamic molecular detection revenues complexity team innovative discovery at idea solution dependent efficient content concentration network 25 commercialization overcome sensitivity networks pathologies clinical resolved limits protein therapeutic tool rate drug boost unable implication treatment drugphosphoprofiler proteome drugs comprehensiveness generating signalling sites disease spectrometry unfortunately roi 12 consequently assay company mechanism biological pharmaceutical ms people systematically clear unmet critical industry

Project "DrugPhosphoProfiler" data sheet

The following table provides information about the project.

Coordinator	OMICSCOUTS GMBH Organization address address: LISE-MEITNER-STRASSE 30 city: FREISING postcode: 85354 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://omicscouts.com/en/
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-1
Funding Scheme	SME-1
Starting year	2019
Duration (year-month-day)	from 2019-08-01 to 2019-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OMICSCOUTS GMBH OMICSCOUTS GMBH Organization address address: LISE-MEITNER-STRASSE 30 city: FREISING postcode: 85354 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREISING)	coordinator	50˙000.00

Map

Project objective

At present there is a huge interest in the pharmaceutical industry to find and develop new drugs targeting protein phosphorylation and their related biological pathways, due to the critical implication of these processes in many pathologies. The high complexity of these phosphorylation-dependent cellular signalling network makes very difficult to have a clear idea about the mechanism of action of a particular drug as well as its side effects. Unfortunately, existing approaches are unable to provide comprehensive, robust and quantitative data of cellular phosphorylation needed to support faster and more efficient drug discovery and development. Consequently, there is a large and unmet need in the pharmaceutical industry for identifying related therapeutic, toxicity targets and biomarkers, in order to develop better drugs. We are developing DrugPhosphoProfiler, an innovative mass spectrometry (MS)-based high-throughput platform for systematically measuring the effects of pharmaceutical agents on phosphorylation-dependent cellular networks in a proteome-wide and drug concentration-resolved manner. DrugPhosphoProfiler will be a unique, high-content drug discovery and development tool capable of providing essential and quantitative molecular pharmacodynamic data based on 25,000 phosphorylation sites in a single assay. The information obtained by our solution will go far beyond existing antibody-based detection systems and overcome their limits in terms of specificity and comprehensiveness without compromising sensitivity and robustness. DrugPhosphoProfiler will thus increase the success rate of pre-clinical drug discovery as well as clinical trials and eventually lead to more effective treatment of disease. Through this project (estimated ROI of 6), we at OmicScouts (SME, Germany) aim to boost the competitiveness of our company, by generating €8.6M revenues and increasing our team to 27 people (from 12), just 5 years after commercialization.

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The information about "DRUGPHOSPHOPROFILER" are provided by the European Opendata Portal: CORDIS opendata.