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ABODYFORCE SIGNED

High Throughput Microfluidic Cell and Nanoparticle Handling by Molecular and Thermal Gradient Acoustic Focusing

Total Cost €

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EC-Contrib. €

0

Partnership

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 ABODYFORCE project word cloud

Explore the words cloud of the ABODYFORCE project. It provides you a very rough idea of what is the project "ABODYFORCE" about.

modulation    geometry    micron    stems    stage    serial    push    potentially    shorter    cells    throughput    aqueous    expose    particles    configurations    technologies    limits    forces    centralized    suspension    body    care    interaction    shift    draw    demands    microscale    molecules    populations    fast    fundamental    theoretical    sought    reasonable    tests    biological    organization    variations    output    size    patient    fluid    flow    lab    circulating    components    diagnostic    tune    render    fractionation    point    microfluidic    isolation    self    ultrasound    force    local    extracellular    tumor    gradients    automated    acoustic    pathogens    amounts    diagnostically    vesicles    framework    extensive    rare    generate    healthcare    sound    bounding    blood    heavy    constituents    simultaneous    ways    separation    medium    small    minutes    discovered    altering    precision    sub    newly    opens    gain    single    regarding    sampling    radiation    time    tailor    format    organizing    platelets    cell    solute    thermal    meet   

Project "ABODYFORCE" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙999˙720 €
 EC max contribution 1˙999˙720 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙999˙720.00

Map

 Project objective

In this project we will push the limits of microscale ultrasound-based technology to gain access to diagnostically important rare constituents of blood within minutes from blood draw.

To meet the demands for shorter time from sampling to result in healthcare there is an increased interest to shift from heavy centralized lab equipment to point-of-care tests and patient self-testing. Key challenges with point-of-care equipment is to enable simultaneous measurement of many parameters at a reasonable cost and size of equipment. Therefore, microscale technologies that can take in small amounts of blood and output results within minutes are sought for. In addition, the high precision and potential for multi-stage serial processing offered by such microfluidic methods opens up for fast and automated isolation of rare cell populations, such as circulating tumor cells, and controlled high-throughput size fractionation of sub-micron biological particles, such as platelets, pathogens and extracellular vesicles.

To achieve effective and fast separation of blood components we will expose blood to acoustic radiation forces in a flow-through format. By exploiting a newly discovered acoustic body force, that stems from local variations the acoustic properties of the cell suspension, we can generate self-organizing configurations of the blood cells. We will tailor and tune the acoustic cell-organization in novel ways by time modulation of the acoustic field, by altering the acoustic properties of the fluid by solute molecules, and by exploiting a novel concept of sound interaction with thermal gradients.

The project will render new fundamental knowledge regarding the acoustic properties of single cells and an extensive theoretical framework for the response of cells in any aqueous medium, bounding geometry and sound field, potentially leading to new diagnostic methods.

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The information about "ABODYFORCE" are provided by the European Opendata Portal: CORDIS opendata.

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