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ABODYFORCE SIGNED

High Throughput Microfluidic Cell and Nanoparticle Handling by Molecular and Thermal Gradient Acoustic Focusing

Total Cost €

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EC-Contrib. €

0

Partnership

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 ABODYFORCE project word cloud

Explore the words cloud of the ABODYFORCE project. It provides you a very rough idea of what is the project "ABODYFORCE" about.

bounding    interaction    constituents    sound    minutes    pathogens    potentially    technologies    variations    opens    organizing    regarding    gradients    ultrasound    rare    newly    framework    circulating    microscale    fast    medium    biological    thermal    precision    solute    self    healthcare    push    demands    discovered    patient    populations    extracellular    fluid    blood    tumor    centralized    tailor    sampling    sub    body    heavy    tests    simultaneous    modulation    altering    shorter    tune    draw    micron    geometry    size    limits    theoretical    aqueous    sought    separation    organization    molecules    isolation    output    small    automated    serial    throughput    local    force    suspension    radiation    platelets    cell    single    ways    expose    components    point    particles    cells    fundamental    meet    care    lab    forces    microfluidic    shift    format    diagnostic    render    stems    vesicles    flow    diagnostically    gain    generate    configurations    time    amounts    acoustic    stage    extensive    reasonable    fractionation   

Project "ABODYFORCE" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙999˙720 €
 EC max contribution 1˙999˙720 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙999˙720.00

Map

 Project objective

In this project we will push the limits of microscale ultrasound-based technology to gain access to diagnostically important rare constituents of blood within minutes from blood draw.

To meet the demands for shorter time from sampling to result in healthcare there is an increased interest to shift from heavy centralized lab equipment to point-of-care tests and patient self-testing. Key challenges with point-of-care equipment is to enable simultaneous measurement of many parameters at a reasonable cost and size of equipment. Therefore, microscale technologies that can take in small amounts of blood and output results within minutes are sought for. In addition, the high precision and potential for multi-stage serial processing offered by such microfluidic methods opens up for fast and automated isolation of rare cell populations, such as circulating tumor cells, and controlled high-throughput size fractionation of sub-micron biological particles, such as platelets, pathogens and extracellular vesicles.

To achieve effective and fast separation of blood components we will expose blood to acoustic radiation forces in a flow-through format. By exploiting a newly discovered acoustic body force, that stems from local variations the acoustic properties of the cell suspension, we can generate self-organizing configurations of the blood cells. We will tailor and tune the acoustic cell-organization in novel ways by time modulation of the acoustic field, by altering the acoustic properties of the fluid by solute molecules, and by exploiting a novel concept of sound interaction with thermal gradients.

The project will render new fundamental knowledge regarding the acoustic properties of single cells and an extensive theoretical framework for the response of cells in any aqueous medium, bounding geometry and sound field, potentially leading to new diagnostic methods.

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The information about "ABODYFORCE" are provided by the European Opendata Portal: CORDIS opendata.

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