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ABODYFORCE SIGNED

High Throughput Microfluidic Cell and Nanoparticle Handling by Molecular and Thermal Gradient Acoustic Focusing

Total Cost €

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EC-Contrib. €

0

Partnership

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 ABODYFORCE project word cloud

Explore the words cloud of the ABODYFORCE project. It provides you a very rough idea of what is the project "ABODYFORCE" about.

fast    amounts    fundamental    format    single    cells    stems    body    throughput    self    output    platelets    regarding    circulating    minutes    radiation    potentially    framework    patient    shorter    shift    reasonable    point    meet    altering    modulation    generate    tests    force    molecules    rare    opens    biological    automated    newly    push    small    microfluidic    blood    technologies    simultaneous    tumor    constituents    organizing    precision    time    fractionation    demands    render    draw    flow    size    tailor    isolation    separation    acoustic    ultrasound    stage    sought    diagnostic    serial    sampling    populations    cell    forces    sub    lab    particles    fluid    organization    bounding    care    interaction    aqueous    medium    pathogens    tune    centralized    vesicles    ways    solute    extracellular    gain    configurations    suspension    extensive    healthcare    sound    theoretical    components    discovered    heavy    expose    gradients    thermal    micron    local    limits    geometry    diagnostically    microscale    variations   

Project "ABODYFORCE" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙999˙720 €
 EC max contribution 1˙999˙720 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙999˙720.00

Map

 Project objective

In this project we will push the limits of microscale ultrasound-based technology to gain access to diagnostically important rare constituents of blood within minutes from blood draw.

To meet the demands for shorter time from sampling to result in healthcare there is an increased interest to shift from heavy centralized lab equipment to point-of-care tests and patient self-testing. Key challenges with point-of-care equipment is to enable simultaneous measurement of many parameters at a reasonable cost and size of equipment. Therefore, microscale technologies that can take in small amounts of blood and output results within minutes are sought for. In addition, the high precision and potential for multi-stage serial processing offered by such microfluidic methods opens up for fast and automated isolation of rare cell populations, such as circulating tumor cells, and controlled high-throughput size fractionation of sub-micron biological particles, such as platelets, pathogens and extracellular vesicles.

To achieve effective and fast separation of blood components we will expose blood to acoustic radiation forces in a flow-through format. By exploiting a newly discovered acoustic body force, that stems from local variations the acoustic properties of the cell suspension, we can generate self-organizing configurations of the blood cells. We will tailor and tune the acoustic cell-organization in novel ways by time modulation of the acoustic field, by altering the acoustic properties of the fluid by solute molecules, and by exploiting a novel concept of sound interaction with thermal gradients.

The project will render new fundamental knowledge regarding the acoustic properties of single cells and an extensive theoretical framework for the response of cells in any aqueous medium, bounding geometry and sound field, potentially leading to new diagnostic methods.

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The information about "ABODYFORCE" are provided by the European Opendata Portal: CORDIS opendata.

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