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AntiHelix SIGNED

DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AntiHelix project word cloud

Explore the words cloud of the AntiHelix project. It provides you a very rough idea of what is the project "AntiHelix" about.

relationships    helicases    educate    proteins    molecular    diverse    stage    reaction    action    companies    separate    private    energy    reproducibility    physiological    competitive    bacteria    revealed    market    mechanisms    single    chemistry    molecule    science    function    antibiotic    commitment    source    date    accessibility    genetic    instrumentation    act    translation    tested    expertise    duplexes    inhibitors    play    mechanism    of    cells    variety    found    skills    structural    experts    discover    dna    academic    secondments    picture    motor    implicated    clinical    full    cancer    biophysical    atp    obtain    biochemical    replication    remodel    eukaryotic    culture    complementary    scientists    cellular    therapeutic    ubiquitous    dimension    drug    structure    training    oncology    rna    viruses    anti    class    job    transparency    techniques    openness    laboratories    coupled    recombination    repair    physics    diseases    enzymes    biology    competence    functions    antiviral    transport    human    generation    discovery    protein    integrity    drugs    cancers    young    archaea    insights    sectors   

Project "AntiHelix" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙508˙622 €
 EC max contribution 3˙508˙622 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 522˙999.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 595˙044.00
3    ELETTRA - SINCROTRONE TRIESTE SCPA IT (BASOVIZZA TRIESTE) participant 522˙999.00
4    LEAD DISCOVERY CENTER GMBH DE (DORTMUND) participant 505˙576.00
5    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 303˙172.00
6    EDELRIS SAS FR (LYON) participant 274˙802.00
7    LUMICKS B.V. NL (AMSTERDAM) participant 265˙619.00
8    STICHTING VU NL (AMSTERDAM) participant 265˙619.00
9    UNIVERSITAETSKLINIKUM ESSEN DE (ESSEN) participant 252˙788.00

Map

 Project objective

Helicases are ubiquitous enzymes, found in viruses, Bacteria, Archaea and eukaryotic cells. They act as motor proteins to separate or remodel DNA or RNA duplexes, using ATP as an energy source. Helicases play a key role in a variety of cellular processes, including DNA replication/repair/recombination, as well as RNA translation and transport. They are emerging as an important class of targets for antiviral, antibiotic and anti-cancer drugs. To date, several genetic and biochemical studies have revealed the molecular and physiological functions of DNA helicases. Moreover, protein three-dimension structural studies coupled with single molecule biophysical approaches have provided insights into structure-function relationships and reaction mechanisms of some key DNA helicases. With a consortium including experts with complementary competence and expertise in Physics, Chemistry, Biology and Clinical Oncology, and a strong commitment of companies involved in drug discovery or in the development of state-of-the-art biophysical instrumentation, we aim to: 1. obtain a detailed picture of the mechanism of action and the physiological role of a number of DNA helicases that are implicated in human diseases; 2. discover specific inhibitors of those enzymes, which can then be tested as novel therapeutic drugs, especially for cancers; 3. address the need for training next generation scientists with complementary approaches and diverse techniques by secondments in different laboratories of the consortium; 4. promote a culture of collaboration between academic and private sectors and provide young scientists with the necessary experience and skills to exploit the full potential of research findings; 5. provide early stage researchers with greater opportunities to access an increasingly competitive job market; 6. promote the values of Open Science and educate young scientists on the importance of a culture of openness, transparency, accessibility, integrity and reproducibility.

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