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AntiHelix SIGNED

DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 AntiHelix project word cloud

Explore the words cloud of the AntiHelix project. It provides you a very rough idea of what is the project "AntiHelix" about.

variety    revealed    commitment    motor    molecular    discovery    physiological    techniques    single    recombination    biophysical    instrumentation    duplexes    action    physics    secondments    atp    genetic    replication    stage    academic    bacteria    dimension    reaction    generation    implicated    protein    clinical    picture    mechanism    molecule    cancer    energy    drug    function    transparency    biology    dna    obtain    found    training    complementary    translation    class    accessibility    archaea    functions    separate    job    anti    young    cells    reproducibility    drugs    remodel    cancers    oncology    educate    human    repair    expertise    cellular    diverse    source    enzymes    scientists    therapeutic    rna    mechanisms    proteins    biochemical    ubiquitous    antibiotic    science    transport    culture    companies    sectors    openness    chemistry    helicases    market    structure    insights    diseases    inhibitors    experts    viruses    eukaryotic    full    competitive    tested    act    private    laboratories    relationships    antiviral    play    integrity    coupled    of    skills    discover    structural    date    competence   

Project "AntiHelix" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙508˙622 €
 EC max contribution 3˙508˙622 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 522˙999.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 595˙044.00
3    ELETTRA - SINCROTRONE TRIESTE SCPA IT (BASOVIZZA TRIESTE) participant 522˙999.00
4    LEAD DISCOVERY CENTER GMBH DE (DORTMUND) participant 505˙576.00
5    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 303˙172.00
6    EDELRIS SAS FR (LYON) participant 274˙802.00
7    LUMICKS B.V. NL (AMSTERDAM) participant 265˙619.00
8    STICHTING VU NL (AMSTERDAM) participant 265˙619.00
9    UNIVERSITAETSKLINIKUM ESSEN DE (ESSEN) participant 252˙788.00

Map

 Project objective

Helicases are ubiquitous enzymes, found in viruses, Bacteria, Archaea and eukaryotic cells. They act as motor proteins to separate or remodel DNA or RNA duplexes, using ATP as an energy source. Helicases play a key role in a variety of cellular processes, including DNA replication/repair/recombination, as well as RNA translation and transport. They are emerging as an important class of targets for antiviral, antibiotic and anti-cancer drugs. To date, several genetic and biochemical studies have revealed the molecular and physiological functions of DNA helicases. Moreover, protein three-dimension structural studies coupled with single molecule biophysical approaches have provided insights into structure-function relationships and reaction mechanisms of some key DNA helicases. With a consortium including experts with complementary competence and expertise in Physics, Chemistry, Biology and Clinical Oncology, and a strong commitment of companies involved in drug discovery or in the development of state-of-the-art biophysical instrumentation, we aim to: 1. obtain a detailed picture of the mechanism of action and the physiological role of a number of DNA helicases that are implicated in human diseases; 2. discover specific inhibitors of those enzymes, which can then be tested as novel therapeutic drugs, especially for cancers; 3. address the need for training next generation scientists with complementary approaches and diverse techniques by secondments in different laboratories of the consortium; 4. promote a culture of collaboration between academic and private sectors and provide young scientists with the necessary experience and skills to exploit the full potential of research findings; 5. provide early stage researchers with greater opportunities to access an increasingly competitive job market; 6. promote the values of Open Science and educate young scientists on the importance of a culture of openness, transparency, accessibility, integrity and reproducibility.

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