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AntiHelix SIGNED

DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AntiHelix project word cloud

Explore the words cloud of the AntiHelix project. It provides you a very rough idea of what is the project "AntiHelix" about.

remodel    skills    scientists    single    stage    obtain    expertise    dna    antiviral    recombination    anti    private    sectors    integrity    biochemical    functions    of    cells    biophysical    ubiquitous    replication    accessibility    repair    generation    clinical    rna    chemistry    cancers    competence    energy    cancer    openness    culture    diverse    coupled    play    instrumentation    structure    proteins    act    full    revealed    source    complementary    techniques    laboratories    mechanisms    insights    separate    reproducibility    physiological    therapeutic    eukaryotic    bacteria    mechanism    archaea    molecule    human    competitive    genetic    dimension    drug    class    translation    experts    cellular    job    function    helicases    companies    relationships    science    viruses    training    transparency    motor    young    structural    reaction    transport    oncology    physics    molecular    found    diseases    market    implicated    drugs    protein    variety    tested    enzymes    discover    academic    educate    inhibitors    action    picture    biology    commitment    atp    discovery    secondments    antibiotic    date    duplexes   

Project "AntiHelix" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙508˙622 €
 EC max contribution 3˙508˙622 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 522˙999.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 595˙044.00
3    ELETTRA - SINCROTRONE TRIESTE SCPA IT (BASOVIZZA TRIESTE) participant 522˙999.00
4    LEAD DISCOVERY CENTER GMBH DE (DORTMUND) participant 505˙576.00
5    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 303˙172.00
6    EDELRIS SAS FR (LYON) participant 274˙802.00
7    LUMICKS B.V. NL (AMSTERDAM) participant 265˙619.00
8    STICHTING VU NL (AMSTERDAM) participant 265˙619.00
9    UNIVERSITAETSKLINIKUM ESSEN DE (ESSEN) participant 252˙788.00

Map

 Project objective

Helicases are ubiquitous enzymes, found in viruses, Bacteria, Archaea and eukaryotic cells. They act as motor proteins to separate or remodel DNA or RNA duplexes, using ATP as an energy source. Helicases play a key role in a variety of cellular processes, including DNA replication/repair/recombination, as well as RNA translation and transport. They are emerging as an important class of targets for antiviral, antibiotic and anti-cancer drugs. To date, several genetic and biochemical studies have revealed the molecular and physiological functions of DNA helicases. Moreover, protein three-dimension structural studies coupled with single molecule biophysical approaches have provided insights into structure-function relationships and reaction mechanisms of some key DNA helicases. With a consortium including experts with complementary competence and expertise in Physics, Chemistry, Biology and Clinical Oncology, and a strong commitment of companies involved in drug discovery or in the development of state-of-the-art biophysical instrumentation, we aim to: 1. obtain a detailed picture of the mechanism of action and the physiological role of a number of DNA helicases that are implicated in human diseases; 2. discover specific inhibitors of those enzymes, which can then be tested as novel therapeutic drugs, especially for cancers; 3. address the need for training next generation scientists with complementary approaches and diverse techniques by secondments in different laboratories of the consortium; 4. promote a culture of collaboration between academic and private sectors and provide young scientists with the necessary experience and skills to exploit the full potential of research findings; 5. provide early stage researchers with greater opportunities to access an increasingly competitive job market; 6. promote the values of Open Science and educate young scientists on the importance of a culture of openness, transparency, accessibility, integrity and reproducibility.

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The information about "ANTIHELIX" are provided by the European Opendata Portal: CORDIS opendata.

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