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KissAndSpitRhoptry SIGNED

Unravelling the secretion machinery for virulence factors in apicomplexan parasites

Total Cost €

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EC-Contrib. €

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Partnership

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 KissAndSpitRhoptry project word cloud

Explore the words cloud of the KissAndSpitRhoptry project. It provides you a very rough idea of what is the project "KissAndSpitRhoptry" about.

cytoplasm    content    employ    inject    act    proteins    equivalent    machinery    membrane    global    bacteria    biochemistry    organelles    cells    bacterial    apicomplexa    rhoptry    plasma    insights    conserved    strength    dissect    depends    electrophysiology    hypothesis    specialized    question    hijack    export    ciliates    virulence    ciliate    explore    attain    mechanism    efforts    secretion    advantage    answers    control    experimental    exocytosis    contrast    assemble    evolutionarily    components    fusion    relative    binding    formed    disrupt    living    model    host    fascinating    share    resolved    effectors    coordinated    discovery    genetics    intracellular    sense    secrete    questions    transient    invasion    full    infection    secretory    parasite    disease    fundamental    eukaryotic    mechanisms    atomic    machine    imaging    genomics    apicomplexan    trigger    resolution    molecular    blueprint    rhoptries    cell    obligatory    parasites    plasmodium    expand    free    tetrahymena    pore    mechanistic    enigma    guide    powerful    toxoplasma    functions    biological   

Project "KissAndSpitRhoptry" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙496˙210 €
 EC max contribution 2˙496˙210 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙496˙210.00

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 Project objective

Apicomplexan are obligatory intracellular parasites. The ability of these parasites (Plasmodium, Toxoplasma) to cause disease depends on the coordinated secretion of specialized secretory organelles. The rhoptries are particularly important, because they act as the apicomplexan equivalent of bacterial secretion systems. They inject parasite proteins directly in the cytoplasm of host cells not only for invasion but also to hijack host functions crucial to establish and maintain infection. However, in contrast to bacteria where the secretion machinery has been resolved to atomic detail, how eukaryotic parasites secrete and inject rhoptry effectors into cells is an enigma. This proposal aims to dissect the mechanistic steps and the molecular components that assemble the rhoptry secretion machine. Our aims are: 1- To explore the mechanisms that trigger rhoptry exocytosis upon binding of the parasite to the host cell. 2- To provide insights into fusion machinery of rhoptry with the parasite plasma membrane. Our model is based on the discovery that free-living Ciliates and intracellular Apicomplexa share an evolutionarily conserved blueprint for their fusion mechanism. 3- To test and expand our hypothesis that rhoptries deliver their content through a transient pore formed into the host cell membrane. We will employ powerful experimental systems in Toxoplasma, Plasmodium and the Ciliate Tetrahymena, taking full advantage of the relative strength of each model. This comprehensive project will bring together comparative genomics, targeted and global genetics, biochemistry, high resolution imaging and electrophysiology. This project answers a question of fundamental biological importance. How can a parasite sense the host cell and inject virulence factors to attain control? Understanding this mechanism will guide future efforts to disrupt parasite infection and will contribute to broader understanding of fascinating questions of membrane fusion and export processes.

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