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FLIX SIGNED

FLow chemistry for Isotopic eXchange

Total Cost €

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EC-Contrib. €

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Partnership

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 FLIX project word cloud

Explore the words cloud of the FLIX project. It provides you a very rough idea of what is the project "FLIX" about.

catalyst    de    batch    imaging    continuous    chemical    diagnostic    ultimate    outcome    stable    organometallic    predetermined    chemicals    isotopes    catalysts    associates    alteration    chemistry    synergistically    tracers    isotope    labeled    straightforward    direct    sectors    stage    biologics    academic    either    industrial    drugs    methoxy    portfolio    14    specialized    trials    atoms    isotopically    multidisciplinary    radically    motifs    accelerating    streamlining    materials    organic    efficacy    reactor    modular    adaptable    unprecedented    labeling    added    screen    devise    15    deuterated    biological    selectively    heavy    compounds    machinery    combinable    line    preclinical    flow    nmr    clinical    drug    innovation    group    loop    utilizes    flix    validate    combination    generations    chemistries    enriched    module    robustness    exchange    12    closed    smart    billion    isotopic    13    positive    mixed    risking    molecules    expertise    modules    reactions   

Project "FLIX" data sheet

The following table provides information about the project.

Coordinator
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES 

Organization address
address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015
website: www.cea.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙469˙740 €
 EC max contribution 3˙469˙740 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) coordinator 849˙000.00
2    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) participant 571˙000.00
3    AARHUS UNIVERSITET DK (AARHUS C) participant 556˙552.00
4    INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE FR (TOULOUSE) participant 489˙687.00
5    LEIBNIZ - INSTITUT FUR KATALYSE EV AN DER UNIVERSITAT ROSTOCK DE (ROSTOCK) participant 479˙750.00
6    COMINNEX KUTATAS FEJLESZTESI ZARTKORUEN MUKODO RESZVENYTARSASAG HU (BUDAPEST) participant 425˙000.00
7    ABSISKEY FR (ANGERS) participant 98˙750.00

Map

 Project objective

FLIX is a radically new concept for the ultimate-stage chemical isotopic labeling of high added-value molecules (drugs, biologics, smart materials) with stable isotopes. It utilizes the unique properties of new generations of catalysts, which specifically and selectively exchange predetermined atoms and chemical motifs of end-use organic compounds. The ultimate outcome of the project is to devise and build a modular and adaptable flow chemistry system for the straightforward and combinable isotopic labeling of complex chemicals and biologics. The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closed-loop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules. The project’s objectives are to: 1) develop new generations of organometallic catalysts for isotopic exchange reactions; 2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness; 3) devise and validate the ‘combinable isotope labeling’ concept; 4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling. FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular: 1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’; 2) design of new tracers for diagnostic imaging with improved biological properties; 3) streamlining the production of multi-labeled complex molecules for NMR studies; 4) the development of novel isotopically-enriched materials.

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The information about "FLIX" are provided by the European Opendata Portal: CORDIS opendata.

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