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FLIX SIGNED

FLow chemistry for Isotopic eXchange

Total Cost €

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EC-Contrib. €

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Partnership

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 FLIX project word cloud

Explore the words cloud of the FLIX project. It provides you a very rough idea of what is the project "FLIX" about.

15    efficacy    sectors    trials    motifs    drug    biologics    academic    atoms    batch    outcome    streamlining    combination    chemicals    adaptable    predetermined    unprecedented    isotopes    module    accelerating    imaging    added    compounds    continuous    risking    industrial    mixed    specialized    chemical    chemistries    robustness    devise    stage    methoxy    catalysts    catalyst    deuterated    nmr    multidisciplinary    ultimate    screen    drugs    associates    group    either    flow    heavy    straightforward    materials    tracers    12    labeling    validate    organometallic    combinable    direct    closed    biological    molecules    loop    billion    13    stable    isotopically    modules    de    expertise    smart    organic    generations    reactions    reactor    enriched    clinical    utilizes    portfolio    innovation    diagnostic    alteration    labeled    positive    line    radically    14    chemistry    machinery    isotope    exchange    flix    synergistically    selectively    isotopic    preclinical    modular   

Project "FLIX" data sheet

The following table provides information about the project.

Coordinator
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES 

Organization address
address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015
website: www.cea.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙469˙740 €
 EC max contribution 3˙469˙740 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) coordinator 849˙000.00
2    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) participant 571˙000.00
3    AARHUS UNIVERSITET DK (AARHUS C) participant 556˙552.00
4    INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE FR (TOULOUSE) participant 489˙687.00
5    LEIBNIZ - INSTITUT FUR KATALYSE EV AN DER UNIVERSITAT ROSTOCK DE (ROSTOCK) participant 479˙750.00
6    COMINNEX KUTATAS FEJLESZTESI ZARTKORUEN MUKODO RESZVENYTARSASAG HU (BUDAPEST) participant 425˙000.00
7    ABSISKEY FR (ANGERS) participant 98˙750.00

Map

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 Project objective

FLIX is a radically new concept for the ultimate-stage chemical isotopic labeling of high added-value molecules (drugs, biologics, smart materials) with stable isotopes. It utilizes the unique properties of new generations of catalysts, which specifically and selectively exchange predetermined atoms and chemical motifs of end-use organic compounds. The ultimate outcome of the project is to devise and build a modular and adaptable flow chemistry system for the straightforward and combinable isotopic labeling of complex chemicals and biologics. The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closed-loop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules. The project’s objectives are to: 1) develop new generations of organometallic catalysts for isotopic exchange reactions; 2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness; 3) devise and validate the ‘combinable isotope labeling’ concept; 4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling. FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular: 1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’; 2) design of new tracers for diagnostic imaging with improved biological properties; 3) streamlining the production of multi-labeled complex molecules for NMR studies; 4) the development of novel isotopically-enriched materials.

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The information about "FLIX" are provided by the European Opendata Portal: CORDIS opendata.

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