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FLIX SIGNED

FLow chemistry for Isotopic eXchange

Total Cost €

EC-Contrib. €

Partnership

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FLIX project word cloud

Explore the words cloud of the FLIX project. It provides you a very rough idea of what is the project "FLIX" about.

clinical academic diagnostic 13 isotopes associates drugs motifs either labeled radically direct billion smart chemicals predetermined combinable stable straightforward outcome labeling batch efficacy combination 12 synergistically added tracers 15 biological mixed reactions positive closed unprecedented methoxy isotopically adaptable robustness machinery modular catalyst nmr specialized selectively accelerating validate trials chemical alteration 14 module biologics chemistries atoms enriched line portfolio utilizes flix reactor group innovation heavy streamlining chemistry devise catalysts screen multidisciplinary isotopic ultimate continuous risking expertise sectors molecules materials industrial generations imaging loop drug flow organic deuterated organometallic de modules exchange compounds isotope preclinical stage

Project "FLIX" data sheet

The following table provides information about the project.

Coordinator	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	3˙469˙740 €
EC max contribution	3˙469˙740 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2018-2019-2020-01
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	coordinator	849˙000.00
2	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	participant	571˙000.00
3	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	556˙552.00
4	INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE Organization address address: AVENUE DE RANGUEIL 135 city: TOULOUSE postcode: 31077 website: www.insa-toulouse.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TOULOUSE)	participant	489˙687.00
5	LEIBNIZ - INSTITUT FUR KATALYSE EV AN DER UNIVERSITAT ROSTOCK LEIBNIZ - INSTITUT FUR KATALYSE EV AN DER UNIVERSITAT ROSTOCK Organization address address: ALBERT-EINSTEIN-STRASSE 29A city: ROSTOCK postcode: 18059 website: www.catalysis.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ROSTOCK)	participant	479˙750.00
6	COMINNEX KUTATAS FEJLESZTESI ZARTKORUEN MUKODO RESZVENYTARSASAG COMINNEX KUTATAS FEJLESZTESI ZARTKORUEN MUKODO RESZVENYTARSASAG Organization address address: ZAHONY U 7 city: BUDAPEST postcode: 1031 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	425˙000.00
7	ABSISKEY ABSISKEY Organization address address: 41B RUE DUPETIT-THOUARS city: ANGERS postcode: 49000 website: http://www.absiskey.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ANGERS)	participant	98˙750.00

Map

Project objective

FLIX is a radically new concept for the ultimate-stage chemical isotopic labeling of high added-value molecules (drugs, biologics, smart materials) with stable isotopes. It utilizes the unique properties of new generations of catalysts, which specifically and selectively exchange predetermined atoms and chemical motifs of end-use organic compounds. The ultimate outcome of the project is to devise and build a modular and adaptable flow chemistry system for the straightforward and combinable isotopic labeling of complex chemicals and biologics. The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closed-loop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules. The project’s objectives are to: 1) develop new generations of organometallic catalysts for isotopic exchange reactions; 2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness; 3) devise and validate the ‘combinable isotope labeling’ concept; 4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling. FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular: 1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’; 2) design of new tracers for diagnostic imaging with improved biological properties; 3) streamlining the production of multi-labeled complex molecules for NMR studies; 4) the development of novel isotopically-enriched materials.

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