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FLIX SIGNED

FLow chemistry for Isotopic eXchange

Total Cost €

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EC-Contrib. €

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Partnership

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 FLIX project word cloud

Explore the words cloud of the FLIX project. It provides you a very rough idea of what is the project "FLIX" about.

multidisciplinary    stable    imaging    direct    either    closed    modules    academic    screen    reactor    efficacy    materials    methoxy    synergistically    clinical    biologics    innovation    biological    outcome    tracers    catalysts    utilizes    devise    unprecedented    exchange    chemistry    stage    12    continuous    de    loop    associates    chemistries    smart    alteration    specialized    expertise    drug    flow    chemical    billion    straightforward    atoms    preclinical    predetermined    deuterated    industrial    streamlining    drugs    combination    robustness    combinable    14    motifs    line    13    organic    added    diagnostic    portfolio    isotopic    accelerating    isotopes    heavy    compounds    trials    selectively    labeling    ultimate    machinery    radically    validate    positive    flix    group    risking    catalyst    module    mixed    generations    chemicals    reactions    labeled    isotopically    sectors    15    molecules    modular    isotope    batch    nmr    adaptable    organometallic    enriched   

Project "FLIX" data sheet

The following table provides information about the project.

Coordinator
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES 

Organization address
address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015
website: www.cea.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙469˙740 €
 EC max contribution 3˙469˙740 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) coordinator 849˙000.00
2    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) participant 571˙000.00
3    AARHUS UNIVERSITET DK (AARHUS C) participant 556˙552.00
4    INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE FR (TOULOUSE) participant 489˙687.00
5    LEIBNIZ - INSTITUT FUR KATALYSE EV AN DER UNIVERSITAT ROSTOCK DE (ROSTOCK) participant 479˙750.00
6    COMINNEX KUTATAS FEJLESZTESI ZARTKORUEN MUKODO RESZVENYTARSASAG HU (BUDAPEST) participant 425˙000.00
7    ABSISKEY FR (ANGERS) participant 98˙750.00

Map

 Project objective

FLIX is a radically new concept for the ultimate-stage chemical isotopic labeling of high added-value molecules (drugs, biologics, smart materials) with stable isotopes. It utilizes the unique properties of new generations of catalysts, which specifically and selectively exchange predetermined atoms and chemical motifs of end-use organic compounds. The ultimate outcome of the project is to devise and build a modular and adaptable flow chemistry system for the straightforward and combinable isotopic labeling of complex chemicals and biologics. The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closed-loop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules. The project’s objectives are to: 1) develop new generations of organometallic catalysts for isotopic exchange reactions; 2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness; 3) devise and validate the ‘combinable isotope labeling’ concept; 4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling. FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular: 1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’; 2) design of new tracers for diagnostic imaging with improved biological properties; 3) streamlining the production of multi-labeled complex molecules for NMR studies; 4) the development of novel isotopically-enriched materials.

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The information about "FLIX" are provided by the European Opendata Portal: CORDIS opendata.

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