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FLIX SIGNED

FLow chemistry for Isotopic eXchange

Total Cost €

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EC-Contrib. €

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Partnership

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 FLIX project word cloud

Explore the words cloud of the FLIX project. It provides you a very rough idea of what is the project "FLIX" about.

closed    multidisciplinary    efficacy    drugs    materials    isotopic    organic    chemistry    exchange    reactions    organometallic    chemistries    biological    modular    portfolio    mixed    flix    ultimate    preclinical    heavy    isotopically    academic    expertise    innovation    14    trials    biologics    13    either    methoxy    de    modules    loop    imaging    combination    generations    machinery    chemical    catalysts    reactor    screen    12    flow    selectively    devise    molecules    added    alteration    atoms    positive    drug    sectors    smart    billion    risking    nmr    motifs    batch    associates    accelerating    deuterated    isotopes    direct    industrial    catalyst    enriched    clinical    adaptable    radically    unprecedented    stable    synergistically    labeled    isotope    module    tracers    group    labeling    predetermined    robustness    diagnostic    stage    utilizes    straightforward    specialized    streamlining    validate    continuous    chemicals    15    combinable    line    compounds    outcome   

Project "FLIX" data sheet

The following table provides information about the project.

Coordinator
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES 

Organization address
address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015
website: www.cea.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙469˙740 €
 EC max contribution 3˙469˙740 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) coordinator 849˙000.00
2    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) participant 571˙000.00
3    AARHUS UNIVERSITET DK (AARHUS C) participant 556˙552.00
4    INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE FR (TOULOUSE) participant 489˙687.00
5    LEIBNIZ - INSTITUT FUR KATALYSE EV AN DER UNIVERSITAT ROSTOCK DE (ROSTOCK) participant 479˙750.00
6    COMINNEX KUTATAS FEJLESZTESI ZARTKORUEN MUKODO RESZVENYTARSASAG HU (BUDAPEST) participant 425˙000.00
7    ABSISKEY FR (ANGERS) participant 98˙750.00

Map

 Project objective

FLIX is a radically new concept for the ultimate-stage chemical isotopic labeling of high added-value molecules (drugs, biologics, smart materials) with stable isotopes. It utilizes the unique properties of new generations of catalysts, which specifically and selectively exchange predetermined atoms and chemical motifs of end-use organic compounds. The ultimate outcome of the project is to devise and build a modular and adaptable flow chemistry system for the straightforward and combinable isotopic labeling of complex chemicals and biologics. The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closed-loop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules. The project’s objectives are to: 1) develop new generations of organometallic catalysts for isotopic exchange reactions; 2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness; 3) devise and validate the ‘combinable isotope labeling’ concept; 4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling. FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular: 1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’; 2) design of new tracers for diagnostic imaging with improved biological properties; 3) streamlining the production of multi-labeled complex molecules for NMR studies; 4) the development of novel isotopically-enriched materials.

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The information about "FLIX" are provided by the European Opendata Portal: CORDIS opendata.

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