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NEUROPA SIGNED

Non-invasive dynamic neural control by laser-based technology

Total Cost €

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EC-Contrib. €

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Partnership

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 NEUROPA project word cloud

Explore the words cloud of the NEUROPA project. It provides you a very rough idea of what is the project "NEUROPA" about.

sources    led    phytoptogenetics    displayed    behavioural    800    europe    faces    monitoring    withdraw    selective    genes    cortico    expression    therapy    cellular    alleviation    discovery    photon    amounting    brain    gene    expertise    laser    15    bidirectional    vivo    models    deep    neuroscientists    selectively    economic    modulated    magnetic    million    photonics    therapeutic    mouse    issue    approximately    drug    invasively    neurons    drugs    engineering    assembled    83    pharmaceutical    ideal    stimulation    efficacy    tackle    loops    patients    treatment    networks    detection    human    dysfunctional    cortical    prove    people    treatments    delivered    wave    billion    phytochrome    lack    disease    diffusing    enormous    toll    huntington    experts    cns    phytochromes    spectroscopy    validation    implicated    transcranial    invasive    excitation    modulation    progress    disorders    neuronal    neuropa    alzheimer    companies    clear    envisage    lab    compact    intervention    network    conventional    symptom    cell    subcortical   

Project "NEUROPA" data sheet

The following table provides information about the project.

Coordinator
ASTON UNIVERSITY 

Organization address
address: ASTON TRIANGLE
city: BIRMINGHAM
postcode: B4 7ET
website: www.aston.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 3˙604˙780 €
 EC max contribution 3˙604˙780 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASTON UNIVERSITY UK (BIRMINGHAM) coordinator 1˙021˙769.00
2    UNIVERSITAT BAYREUTH DE (BAYREUTH) participant 531˙843.00
3    OULUN YLIOPISTO FI (OULU) participant 523˙528.00
4    PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT HU (SZEGED) participant 478˙625.00
5    UNIVERSITAT DE BARCELONA ES (BARCELONA) participant 451˙070.00
6    SORBONNE UNIVERSITE FR (PARIS) participant 404˙500.00
7    DLM CONSULTANCY SERVICES LTD UK (HUDDERSFIELD) participant 193˙443.00

Map

 Project objective

Europe faces an enormous human toll of brain disorders, with an estimated 83 million people affected, and economic costs amounting to approximately €800 billion. Drug treatments for brain disorders prove often less than effective with a lack of selective cell targeting. A failure to develop new drugs has led major Pharmaceutical companies to withdraw from CNS drug development in recent years. Methods such as Transcranial Magnetic Stimulation or Deep Brain Stimulation have displayed some therapeutic efficacy, however they are non-selective and/or invasive. It is therefore clear that with a failure of conventional therapy, a new approach is necessary, and development of new technology. NEUROPA will directly tackle this issue. An ideal treatment would be one where activity in specific implicated neuronal networks could be selectively modulated. To be relevant to human disorders the therapy should enable the long-term modulation of dysfunctional networks. For potential widespread use in patients the intervention and monitoring of effects on network activity should also be non-invasive. NEUROPA will develop a new Phytoptogenetics technology: novel Phytochromes that will enable modulation of expression of specific genes, selectively and non-invasively delivered and targeted to cortical neurons in specific cortico-subcortical loops. Novel compact laser sources and a Diffusing Wave Spectroscopy monitoring system will be developed to enable non-invasive bidirectional control of the phytochromes by two-photon excitation. NEUROPA will achieve in-lab technology validation of long-term network activity modulation and behavioural symptom alleviation in Huntington’s and Alzheimer’s disease mouse models. To achieve this, we have assembled a consortium of phytochrome engineering, gene delivery, laser photonics and detection experts, cellular, in vivo and behavioural neuroscientists, together with drug discovery expertise. We envisage progress to human use within 15 years.

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