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NEUROPA SIGNED

Non-invasive dynamic neural control by laser-based technology

Total Cost €

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EC-Contrib. €

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Partnership

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 NEUROPA project word cloud

Explore the words cloud of the NEUROPA project. It provides you a very rough idea of what is the project "NEUROPA" about.

invasive    transcranial    intervention    therapy    economic    excitation    assembled    cell    cortical    engineering    compact    huntington    behavioural    displayed    human    cns    treatment    led    prove    vivo    validation    mouse    deep    phytochromes    europe    models    diffusing    therapeutic    discovery    efficacy    alleviation    photonics    expression    bidirectional    loops    expertise    modulation    gene    issue    laser    ideal    treatments    15    dysfunctional    modulated    withdraw    networks    people    disease    magnetic    drugs    delivered    million    invasively    neuronal    phytochrome    disorders    symptom    alzheimer    neurons    progress    clear    brain    sources    cellular    cortico    enormous    lack    drug    phytoptogenetics    83    genes    envisage    photon    monitoring    tackle    patients    stimulation    toll    neuroscientists    faces    network    wave    detection    amounting    neuropa    companies    spectroscopy    conventional    pharmaceutical    subcortical    approximately    800    billion    selectively    selective    experts    implicated    lab   

Project "NEUROPA" data sheet

The following table provides information about the project.

Coordinator
ASTON UNIVERSITY 

Organization address
address: ASTON TRIANGLE
city: BIRMINGHAM
postcode: B4 7ET
website: www.aston.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 3˙604˙780 €
 EC max contribution 3˙604˙780 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASTON UNIVERSITY UK (BIRMINGHAM) coordinator 1˙021˙769.00
2    UNIVERSITAT BAYREUTH DE (BAYREUTH) participant 531˙843.00
3    OULUN YLIOPISTO FI (OULU) participant 523˙528.00
4    PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT HU (SZEGED) participant 478˙625.00
5    UNIVERSITAT DE BARCELONA ES (BARCELONA) participant 451˙070.00
6    SORBONNE UNIVERSITE FR (PARIS) participant 404˙500.00
7    DLM CONSULTANCY SERVICES LTD UK (HUDDERSFIELD) participant 193˙443.00

Map

 Project objective

Europe faces an enormous human toll of brain disorders, with an estimated 83 million people affected, and economic costs amounting to approximately €800 billion. Drug treatments for brain disorders prove often less than effective with a lack of selective cell targeting. A failure to develop new drugs has led major Pharmaceutical companies to withdraw from CNS drug development in recent years. Methods such as Transcranial Magnetic Stimulation or Deep Brain Stimulation have displayed some therapeutic efficacy, however they are non-selective and/or invasive. It is therefore clear that with a failure of conventional therapy, a new approach is necessary, and development of new technology. NEUROPA will directly tackle this issue. An ideal treatment would be one where activity in specific implicated neuronal networks could be selectively modulated. To be relevant to human disorders the therapy should enable the long-term modulation of dysfunctional networks. For potential widespread use in patients the intervention and monitoring of effects on network activity should also be non-invasive. NEUROPA will develop a new Phytoptogenetics technology: novel Phytochromes that will enable modulation of expression of specific genes, selectively and non-invasively delivered and targeted to cortical neurons in specific cortico-subcortical loops. Novel compact laser sources and a Diffusing Wave Spectroscopy monitoring system will be developed to enable non-invasive bidirectional control of the phytochromes by two-photon excitation. NEUROPA will achieve in-lab technology validation of long-term network activity modulation and behavioural symptom alleviation in Huntington’s and Alzheimer’s disease mouse models. To achieve this, we have assembled a consortium of phytochrome engineering, gene delivery, laser photonics and detection experts, cellular, in vivo and behavioural neuroscientists, together with drug discovery expertise. We envisage progress to human use within 15 years.

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