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NanoChemBioVision SIGNED

Next Generation Label-free Chemical Nanoscopy for Biomedical Applications

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoChemBioVision project word cloud

Explore the words cloud of the NanoChemBioVision project. It provides you a very rough idea of what is the project "NanoChemBioVision" about.

revolutionize    disease    ultra    decline    unravelling    modulation    vesicular    intrinsic    chemical    capability    single    cognitive    limit    unseen    coupled    chemically    solution    microscope    lt    selectively    yielding    light    infected    not    ageing    itself    scattering    techniques    therapeutics    molecules    generation    opening    linear    time    frequency    selective    biochemical    biology    below    viral    rate    outcomes    biomolecules    causing    unprecedented    axons    simply    nanoscopy    crs    endogenous    oscillatory    molecular    mixing    allergy    super    implementing    infection    resolution    invasive    tampering    neurodegenerative    biomedical    free    microscopy    doors    frontier    video    coherent    raman    imaging    image    vsfg    nm    transport    specimen    mechanisms    uniquely    detected    virus    phenomena    ultimately    structures    overcome    destruction    spatial    sum    manifests    conventional    label    structure    see    diagnostics    imagine    destructive    optical    disorders    neurons    utility    biological    vibrational    wavelength   

Project "NanoChemBioVision" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF SOUTHAMPTON 

Organization address
address: Highfield
city: SOUTHAMPTON
postcode: SO17 1BJ
website: http://www.southampton.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.southampton.ac.uk/mbpi
 Total cost 1˙916˙076 €
 EC max contribution 1˙916˙076 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF SOUTHAMPTON UK (SOUTHAMPTON) coordinator 1˙916˙076.00

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 Project objective

Imagine if one could simply use an optical microscope and see whether a particular virus has infected a biological specimen or not! Or if a single disease causing molecular structure could be detected, 20 years before the disease manifests itself! Conventional microscopy simply does not have such spatial resolution! The challenge is to image endogenous molecules and structures composed of them specifically, in real-time, without tampering and sample destruction. Non-Linear optical techniques such as vibrational sum frequency generation (vSFG) and coherent Raman scattering (CRS), which use the intrinsic properties of molecules for selectively imaging them, provide a solution. They are non-invasive, label-free, chemically selective and non-destructive with capability for video-rate imaging of biomolecules and biochemical structures. However, they need to overcome the frontier of spatial resolution to be able to provide information at <100 nm level, which is much below the limit for these techniques and conventional microscopy. The proposal addresses this challenge by developing and implementing a generic, simple optical ultra-high resolution technology using a novel approach based on super-oscillatory modulation of light coupled with wavelength mixing. We will uniquely apply this approach to the chemically selective vSFG and CRS techniques. Ultra-high spatial resolution with these techniques will allow unprecedented new insight into many biochemical phenomena. To demonstrate the utility of ‘chemical nanoscopy’ developed in this proposal vesicular transport in axons of neurons will be studied, which is highly relevant to cognitive decline observed in ageing and neurodegenerative disorders. The project outcomes have the potential to revolutionize research and biomedical understanding by opening doors to ‘unseen biology’, unravelling disease, viral infection and allergy mechanisms and ultimately, yielding better diagnostics and therapeutics.

 Publications

year authors and title journal last update
List of publications.
2018 Katrine S. Rogers, Konstantinos N. Bourdakos, Guang Hui Yuan, Sumeet Mahajan, Edward T. F. Rogers
Optimising superoscillatory spots for far-field super-resolution imaging
published pages: 8095, ISSN: 1094-4087, DOI: 10.1364/oe.26.008095
Optics Express 26/7 2019-12-16
2018 Catarina Costa Moura, Stuart A. Lanham, Tual Monfort, Konstantinos N. Bourdakos, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Quantitative temporal interrogation in 3D of bioengineered human cartilage using multimodal label-free imaging
published pages: 635-645, ISSN: 1757-9694, DOI: 10.1039/c8ib00050f
Integrative Biology 10/10 2019-12-16
2018 William J. Anderson, Kamila Nowinska, Tanya Hutter, Sumeet Mahajan, Martin Fischlechner
Tuning plasmons layer-by-layer for quantitative colloidal sensing with surface-enhanced Raman spectroscopy
published pages: 7138-7146, ISSN: 2040-3364, DOI: 10.1039/c7nr06656b
Nanoscale 10/15 2019-12-16
2016 Jack Taylor, Anna Huefner, Li Li, Jonathan Wingfield, Sumeet Mahajan
Nanoparticles and intracellular applications of surface-enhanced Raman spectroscopy
published pages: 5037-5055, ISSN: 0003-2654, DOI: 10.1039/c6an01003b
The Analyst 141/17 2019-12-16
2017 Alan N. Hunt, Anagha Malur, Tual Monfort, Pavlos Lagoudakis, Sumeet Mahajan, Anthony D. Postle, Mary Jane Thomassen
Hepatic Steatosis Accompanies Pulmonary Alveolar Proteinosis
published pages: 448-458, ISSN: 1044-1549, DOI: 10.1165/rcmb.2016-0242oc
American Journal of Respiratory Cell and Molecular Biology 57/4 2019-12-16
2018 George Devitt, Kelly Howard, Amrit Mudher, Sumeet Mahajan
Raman Spectroscopy: An Emerging Tool in Neurodegenerative Disease Research and Diagnosis
published pages: 404-420, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.7b00413
ACS Chemical Neuroscience 9/3 2019-12-16
2018 Mark G Jones, Orestis G Andriotis, James JW Roberts, Kerry Lunn, Victoria J Tear, Lucy Cao, Kjetil Ask, David E Smart, Alessandra Bonfanti, Peter Johnson, Aiman Alzetani, Franco Conforti, Regan Doherty, Chester Y Lai, Benjamin Johnson, Konstantinos N Bourdakos, Sophie V Fletcher, Ben G Marshall, Sanjay Jogai, Christopher J Brereton, Serena J Chee, Christian H Ottensmeier, Patricia Sime, Jack Gauld
Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.36354
eLife 7 2019-12-16
2015 Anna Huefner, Wei-Li Kuan, Karin H. Müller, Jeremy N. Skepper, Roger A. Barker, Sumeet Mahajan
Characterization and Visualization of Vesicles in the Endo-Lysosomal Pathway with Surface-Enhanced Raman Spectroscopy and Chemometrics
published pages: 307-316, ISSN: 1936-0851, DOI: 10.1021/acsnano.5b04456
ACS Nano 10/1 2019-05-29
2016 Catarina Costa Moura, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Raman spectroscopy and coherent anti-Stokes Raman scattering imaging: prospective tools for monitoring skeletal cells and skeletal regeneration
published pages: 20160182, ISSN: 1742-5689, DOI: 10.1098/rsif.2016.0182
Journal of The Royal Society Interface 13/118 2019-05-29
2015 Justyna P. Smus, Catarina Costa Moura, Emma McMorrow, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Tracking adipogenic differentiation of skeletal stem cells by label-free chemically selective imaging
published pages: 7089-7096, ISSN: 2041-6520, DOI: 10.1039/C5SC02168E
Chemical Science 6/12 2019-05-29

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