Explore the words cloud of the NanoChemBioVision project. It provides you a very rough idea of what is the project "NanoChemBioVision" about.
The following table provides information about the project.
UNIVERSITY OF SOUTHAMPTON
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙916˙076 €|
|EC max contribution||1˙916˙076 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-04-01 to 2020-03-31|
Take a look of project's partnership.
|1||UNIVERSITY OF SOUTHAMPTON||UK (SOUTHAMPTON)||coordinator||1˙916˙076.00|
Imagine if one could simply use an optical microscope and see whether a particular virus has infected a biological specimen or not! Or if a single disease causing molecular structure could be detected, 20 years before the disease manifests itself! Conventional microscopy simply does not have such spatial resolution! The challenge is to image endogenous molecules and structures composed of them specifically, in real-time, without tampering and sample destruction. Non-Linear optical techniques such as vibrational sum frequency generation (vSFG) and coherent Raman scattering (CRS), which use the intrinsic properties of molecules for selectively imaging them, provide a solution. They are non-invasive, label-free, chemically selective and non-destructive with capability for video-rate imaging of biomolecules and biochemical structures. However, they need to overcome the frontier of spatial resolution to be able to provide information at <100 nm level, which is much below the limit for these techniques and conventional microscopy. The proposal addresses this challenge by developing and implementing a generic, simple optical ultra-high resolution technology using a novel approach based on super-oscillatory modulation of light coupled with wavelength mixing. We will uniquely apply this approach to the chemically selective vSFG and CRS techniques. Ultra-high spatial resolution with these techniques will allow unprecedented new insight into many biochemical phenomena. To demonstrate the utility of ‘chemical nanoscopy’ developed in this proposal vesicular transport in axons of neurons will be studied, which is highly relevant to cognitive decline observed in ageing and neurodegenerative disorders. The project outcomes have the potential to revolutionize research and biomedical understanding by opening doors to ‘unseen biology’, unravelling disease, viral infection and allergy mechanisms and ultimately, yielding better diagnostics and therapeutics.
|year||authors and title||journal||last update|
Katrine S. Rogers, Konstantinos N. Bourdakos, Guang Hui Yuan, Sumeet Mahajan, Edward T. F. Rogers
Optimising superoscillatory spots for far-field super-resolution imaging
published pages: 8095, ISSN: 1094-4087, DOI: 10.1364/oe.26.008095
|Optics Express 26/7||2019-12-16|
Catarina Costa Moura, Stuart A. Lanham, Tual Monfort, Konstantinos N. Bourdakos, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Quantitative temporal interrogation in 3D of bioengineered human cartilage using multimodal label-free imaging
published pages: 635-645, ISSN: 1757-9694, DOI: 10.1039/c8ib00050f
|Integrative Biology 10/10||2019-12-16|
William J. Anderson, Kamila Nowinska, Tanya Hutter, Sumeet Mahajan, Martin Fischlechner
Tuning plasmons layer-by-layer for quantitative colloidal sensing with surface-enhanced Raman spectroscopy
published pages: 7138-7146, ISSN: 2040-3364, DOI: 10.1039/c7nr06656b
Jack Taylor, Anna Huefner, Li Li, Jonathan Wingfield, Sumeet Mahajan
Nanoparticles and intracellular applications of surface-enhanced Raman spectroscopy
published pages: 5037-5055, ISSN: 0003-2654, DOI: 10.1039/c6an01003b
|The Analyst 141/17||2019-12-16|
Alan N. Hunt, Anagha Malur, Tual Monfort, Pavlos Lagoudakis, Sumeet Mahajan, Anthony D. Postle, Mary Jane Thomassen
Hepatic Steatosis Accompanies Pulmonary Alveolar Proteinosis
published pages: 448-458, ISSN: 1044-1549, DOI: 10.1165/rcmb.2016-0242oc
|American Journal of Respiratory Cell and Molecular Biology 57/4||2019-12-16|
George Devitt, Kelly Howard, Amrit Mudher, Sumeet Mahajan
Raman Spectroscopy: An Emerging Tool in Neurodegenerative Disease Research and Diagnosis
published pages: 404-420, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.7b00413
|ACS Chemical Neuroscience 9/3||2019-12-16|
Mark G Jones, Orestis G Andriotis, James JW Roberts, Kerry Lunn, Victoria J Tear, Lucy Cao, Kjetil Ask, David E Smart, Alessandra Bonfanti, Peter Johnson, Aiman Alzetani, Franco Conforti, Regan Doherty, Chester Y Lai, Benjamin Johnson, Konstantinos N Bourdakos, Sophie V Fletcher, Ben G Marshall, Sanjay Jogai, Christopher J Brereton, Serena J Chee, Christian H Ottensmeier, Patricia Sime, Jack Gauld
Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.36354
Anna Huefner, Wei-Li Kuan, Karin H. MÃ¼ller, Jeremy N. Skepper, Roger A. Barker, Sumeet Mahajan
Characterization and Visualization of Vesicles in the Endo-Lysosomal Pathway with Surface-Enhanced Raman Spectroscopy and Chemometrics
published pages: 307-316, ISSN: 1936-0851, DOI: 10.1021/acsnano.5b04456
|ACS Nano 10/1||2019-05-29|
Catarina Costa Moura, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Raman spectroscopy and coherent anti-Stokes Raman scattering imaging: prospective tools for monitoring skeletal cells and skeletal regeneration
published pages: 20160182, ISSN: 1742-5689, DOI: 10.1098/rsif.2016.0182
|Journal of The Royal Society Interface 13/118||2019-05-29|
Justyna P. Smus, Catarina Costa Moura, Emma McMorrow, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Tracking adipogenic differentiation of skeletal stem cells by label-free chemically selective imaging
published pages: 7089-7096, ISSN: 2041-6520, DOI: 10.1039/C5SC02168E
|Chemical Science 6/12||2019-05-29|
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The information about "NANOCHEMBIOVISION" are provided by the European Opendata Portal: CORDIS opendata.
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